Results 171 to 180 of about 2,906 (266)

Deep Learning Prediction of Surface Roughness in Multi‐Stage Microneedle Fabrication: A Long Short‐Term Memory‐Recurrent Neural Network Approach

Advanced Intelligent Discovery, EarlyView.
A sequential deep learning framework is developed to model surface roughness progression in multi‐stage microneedle fabrication. Using real‐world experimental data from 3D printing, molding, and casting stages, an long short‐term memory‐based recurrent neural network captures the cumulative influence of geometric parameters and intermediate outputs ...
Abdollah Ahmadpour, Sara Soltanabadi Farshi, Tuanna Ozcan, Amir Mohammad Ketabchi, Alper Kiraz, Savas Tasoglu   +5 more
wiley   +1 more source

Accelerating Primary Screening of USP8 Inhibitors from Drug Repurposing Databases with Tree‐Based Machine Learning

Advanced Intelligent Discovery, EarlyView.
This study introduces a tree‐based machine learning approach to accelerate USP8 inhibitor discovery. The best‐performing model identified 100 high‐confidence repurposable compounds, half already approved or in clinical trials, and uncovered novel scaffolds not previously studied. These findings offer a solid foundation for rapid experimental follow‐up,
Yik Kwong Ng, Sharon Ai Er Lam, Wei Chun Lim, Hannah Hui Min Toh, Shi Jun Ang   +4 more
wiley   +1 more source

A general strategy for high-efficiency live bacteria imaging and targeted phototherapy. [PDF]

Chem Sci
Wang X, Ding L, Liu J, Lv J, Liu J, Yan Y, Li X, Shi H, Wang H, Wang J, Liu S, Cao D, Yang X, Xue L.   +13 more
europepmc   +1 more source

Exploring the lichenization continuum through the marine tripartite symbiosis of Collemopsidium pelvetiae

American Journal of Botany, EarlyView.
Abstract Premise Symbioses between lichen‐forming fungi and brown algae (phaeophytes) are extremely rare. We investigated the interactions between the marine fungus Collemopsidium pelvetiae and its two photosynthetic partners, the brown alga Pelvetia canaliculata and a cyanobacterial symbiont to address questions on symbiosis biology, lichenization ...
Sergio Pérez‐Ortega, Rúdiger Ortiz‐Álvarez, Jacek Wierzchos, Miguel Blázquez, Alain Gérault, Asunción de los Ríos   +5 more
wiley   +1 more source

Thioether editing generally increases the photostability of rhodamine dyes on self-labeling tags. [PDF]

Proc Natl Acad Sci U S A
Ling J, Zhang Y, Hei Y, Kompa J, Yang C, Wang B, Zhang J, Du J, Rudi T, Zhang K, Sun J, Wang W, Fabritz S, Li Y, Deng W, Zou P, Chen C, Chen Z.   +17 more
europepmc   +1 more source

Pollination by long‐proboscid horseflies and its implications for reproductive isolation among coflowering Satyrium orchids in South Africa

American Journal of Botany, EarlyView.
Abstract Premise Floral adaptations to pollinators can drive lineage diversification and promote coexistence of species. We investigated the reproductive biology of Satyrium longicolle, a South African orchid that we hypothesized to belong to a long‐proboscid horsefly pollination guild and examined overlap of pollinators and floral traits among ...
Steven D. Johnson, Matthew Moir, Ethan Newman, Timotheüs Van der Niet   +3 more
wiley   +1 more source

Advancing Single-Molecule Biophysics: Next-Generation Organic Fluorophores with Tailored Labeling Strategies. [PDF]

Chem Biomed Imaging
Zhang L, Shen D, Yang J.
europepmc   +1 more source

Cerebrospinal Fluid from Restless Legs Syndrome Patients Reduces Iron Uptake in Blood–Brain Barrier Endothelial Cells by Disrupting the Regulation of Transferrin Receptors

Annals of Neurology, EarlyView.
Model figure of BBBECs TfR1 regulation in control and RLS: Graphical representation of TfR1 regulation in ECs by IRPs and representing it can be dysregulated by miR‐124‐3p in ECs of RLS. FPN1, ferroportin; BBBEC, blood‐brain barrier endothelial cells; IRP, iron regulatory proytein1/2; TfR1, Transferrin receptor; IRE, Iron responsive elements; Tf ...
Kondaiah Palsa, Aurosman Pappus Sahu, David B. Rye, Lynn Marie Trotti, Irina A. Elcheva, Vladimir S. Spiegelman, James R. Connor   +6 more
wiley   +1 more source

Chemical fluorophores for fluorescence lifetime imaging. [PDF]

Chem Soc Rev
Lim C, Seah D, Vendrell M.
europepmc   +1 more source

Therapeutic Applications of Stimuli‐Based Release and Engineering of Extracellular Vesicles

Advanced NanoBiomed Research, EarlyView.
This review summarizes the effects of endogenous and exogenous stimuli, their effects on the natural release of extracellular vesicles, as well as their uptake and release. It also gives an overview of stimuli‐responsive EVs and their therapeutic applications. Extracellular vesicles (EVs), nano‐ to microsized lipid bilayer membrane‐bound particles, are
Gloria Kemunto, Kristen Dellinger
wiley   +1 more source