Results 81 to 90 of about 7,672 (250)

Potential Mechanism of Detoxification of Cyanide Compounds by Gut Microbiomes of Bamboo-Eating Pandas

mSphere, 2018
Gut microbes can enhance the ability of hosts to consume secondary plant compounds and, therefore, expand the dietary niche breadth of mammalian herbivores.
Lifeng Zhu, Zhisong Yang, Ran Yao, Liangliang Xu, Hua Chen, Xiaodong Gu, Tonggui Wu, Xuyu Yang   +7 more
doaj   +1 more source

Investigations on the microbial catabolism of the organic sulfur compounds TDP and DTDP in H16 employing DNA microarrays [PDF]

, 2010
In this study, we have investigated the transcriptome of Ralstonia eutropha H16 during cultivation with gluconate in presence of 3,3'-thiodipropionic acid (TDP) or 3,3'-dithiodipropionic acid (DTDP) during biosynthesis of poly(3-hydroxybutyrate-co-3 ...
Alexander Steinbüchel, Armin Ehrenreich, Christina Döring, Katja Peplinski, Mechthild Bömeke   +4 more
core   +2 more sources

Cyanide Beyond Toxicity: A Systematic Review of Its Effects on Vascular Function

Basic &Clinical Pharmacology &Toxicology, Volume 137, Issue 5, November 2025.
ABSTRACT Cyanide is widely recognized for its potent toxicity, yet evidence shows that concentrations below 1 μM may enhance cytochrome c oxidase activity and have a regulatory function. Recent findings also demonstrate that mammalian cells, including endothelial cells, produce cyanide endogenously, where it can modulate mitochondrial bioenergetics ...
Elif Alan‐Albayrak, Ulf Simonsen
wiley   +1 more source

New Insights Into Acidithiobacillus thiooxidans Sulfur Metabolism Through Coupled Gene Expression, Solution Chemistry, Microscopy, and Spectroscopy Analyses

Frontiers in Microbiology, 2020
Here, we experimentally expand understanding of the reactions and enzymes involved in Acidithiobacillus thiooxidans ATCC 19377 S0 and S2⁢O32- metabolism by developing models that integrate gene expression analyzed by RNA-Seq, solution sulfur speciation ...
David Camacho, Rodolfo Frazao, Aurélien Fouillen, Aurélien Fouillen, Antonio Nanci, Antonio Nanci, B. Franz Lang, Simon C. Apte, Christian Baron, Lesley A. Warren, Lesley A. Warren   +10 more
doaj   +1 more source

Solvent content of protein crystals from diffraction intensities by Independent Component Analysis [PDF]

, 2003
An analysis of the protein content of several crystal forms of proteins has been performed. We apply a new numerical technique, the Independent Component Analysis (ICA), to determine the volume fraction of the asymmetric unit occupied by the protein ...
A. Lamura, Authier, Cedergren-Zeppezauer, Comon, Cover, D. Siliqi, Dauter, Dauter, G. Nico, Giacovazzo, Glover, Hecht, Hecht, Hofmann, Huber, Hyvärinen, Hyvärinen, Hyvärinen, Jiang, Jones, Jutten, Kantardjeff, Kostrewa, Kostrewa, Massimo Ladisa, Matak-Vinkovic, Mattevi, Matthews, Moews, Moore, Morris, Papoulis, Spallarossa, Toro, Urzhumtsev   +34 more
core   +1 more source

S-Nitrosylation Induces Structural and Dynamical Changes in a Rhodanese Family Protein

Journal of Molecular Biology, 2016
S-Nitrosylation is well established as an important post-translational regulator in protein function and signaling. However, relatively little is known about its structural and dynamical consequences.
Cédric Eichmann, Christos Tzitzilonis, Tomohiro Nakamura, W. Kwiatkowski, I. Maslennikov, S. Choe, S. Lipton, R. Riek   +7 more
semanticscholar   +1 more source

Effect of 3‐mercaptopyruvate sulfurtransferase (3‐MST) inhibitors on contractile responses in porcine coronary artery

British Journal of Pharmacology, Volume 182, Issue 22, Page 5453-5468, November 2025.
Background and Purpose Hydrogen sulphide (H2S) is synthesised endogenously through cystathionine β‐synthase (CBS), cystathionine γ‐lyase (CSE) and 3‐mercaptopyruvate sulfurtransferase (3‐MST). Although exogenous H2S is known to produce vasodilatation, the vascular effect of H2S produced through 3‐MST is unknown. In this study, we demonstrate the effect
Maha Almaheize, Sahar Alharthi, Patricia Hemp, Jennifer Mattos, Marcus van Leer, Michael Garle, Stephen Alexander, Richard Roberts   +7 more
wiley   +1 more source

In Hyphomicrobium denitrificans Two Related Sulfane‐Sulfur Responsive Transcriptional Repressors Regulate Thiosulfate Oxidation and Have a Deep Impact on Nitrate Respiration and Anaerobic Biosyntheses

Molecular Microbiology, Volume 124, Issue 3, Page 204-220, September 2025.
In Hyphomicrobium denitrificans, the use of thiosulfate as a supplemental electron donor is regulated by two homologous sulfane‐sulfur responsive ArsR‐type transcriptional repressors, sHdrR and SoxR, that act cooperatively. Remarkably, the regulation by sHdrR/SoxR extends far beyond sulfur oxidation and deeply affects anaerobic metabolism, particularly
Jingjing Li, Nora E. Schmitte, Kaya Törkel, Christiane Dahl   +3 more
wiley   +1 more source

Thiosulfate sulfurtransferase prevents hyperglycemic damage to the zebrafish pronephros in an experimental model for diabetes

Scientific Reports, 2022
Thiosulfate sulfurtransferase (TST, EC 2.8.1.1), also known as Rhodanese, was initially discovered as a cyanide detoxification enzyme. However, it was recently also found to be a genetic predictor of resistance to obesity-related type 2 diabetes ...
Zayana M. Al-Dahmani, Xiaogang Li, Lucas M. Wiggenhauser, Hannes Ott, Paul D. Kruithof, Sergey Lunev, Fernando A. Batista, Yang Luo, Amalia M. Dolga, Nicholas M. Morton, Matthew R. Groves, Jens Kroll, Harry van Goor   +12 more
doaj   +1 more source

Redirecting Intermediary Metabolism to Counteract Cyanide Poisoning

The FASEB Journal, Volume 39, Issue 12, 30 June 2025.
Cyanide is coined “the classic metabolic poison”; however, FDA‐approved cyanide chelators do not counteract cyanide's metabolic damage. Here, we review the mechanisms of cyanide toxicity, with a focus on intermediary metabolism. We present the theory that, within the innate plasticity of the metabolome, there may reside metabolic pathways that can ...
Vik S. Bebarta, Anjali K. Nath
wiley   +1 more source