Results 71 to 80 of about 23,669 (207)

The Equine Antimicrobial Peptide eCATH1 Is Effective against the Facultative Intracellular Pathogen Rhodococcus equi in Mice

, 2013
Rhodococcus equi, the causal agent of rhodococcosis, is a major pathogen of foals and is also responsible for severe infections in immunocompromised humans. Of great concern, strains resistant to currently used antibiotics have emerged.
Schlusselhuber, Margot, Leclercq, Roland, Martini, Cecilia, Cattoir, Vincent, Torelli, Riccardo, Leippe, Matthias, Cauchard, Julien, Sanguinetti, Maurizio, Grötzinger, Joachim, Laugier, Claire   +9 more
core   +1 more source

Clonal Confinement of a Highly Mobile Resistance Element Driven by Combination Therapy in Rhodococcus equi

mBio, 2019
Antibiotic use has been linked to changes in the population structure of human pathogens and the clonal expansion of multidrug-resistant (MDR) strains among healthcare- and community-acquired infections.
Sonsiray Álvarez-Narváez, Steeve Giguère, Elisa Anastasi, Jack Hearn, Mariela Scortti, José A. Vázquez-Boland   +5 more
doaj   +1 more source

Drug Design and Delivery for Intracellular Bacteria: Emerging Paradigms

Drug Development Research, Volume 86, Issue 8, December 2025.
ABSTRACT Intracellular bacteria exploit host cell niches, such as lysosomes, phagosomes, cytosol, entire cells, and even erythrocytes, to evade immune clearance and escape conventional antibiotics. These environments pose numerous therapeutic challenges, including crossing host cell membranes, navigating endosomal trafficking, tolerating acidic and ...
Babatunde Ibrahim Olowu, Maryam Ebunoluwa Zakariya, Abdulmuheez Abiola Abdulkareem, Olalekan Toheeb Okewale, Muhammad Halima Idris, Halimah Oluwayemisi Olayiwola   +5 more
wiley   +1 more source

Antimicrobial Resistance in Rhodococcus equi

Microbiology Spectrum, 2017
ABSTRACT Pneumonia caused by Rhodococcus equi remains an important cause of disease and death in foals. The combination of a macrolide (erythromycin, azithromycin, or clarithromycin) with rifampin has been the recommended treatment for foals with clinical signs of infection caused by R. equi
Steeve, Giguère, Londa J, Berghaus, Jennifer M, Willingham-Lane   +2 more
openaire   +2 more sources

Novel Nonsense Mutation in SMARCD2 Gene Results in Dysplasia of All Myeloid Cell Lines

eJHaem, Volume 6, Issue 6, December 2025.
ABSTRACT Introduction Specific granule deficiency type II (SGD2) is a rare heterogeneous congenital disease characterized by early‐onset life‐threatening infections. SGD2 is caused by autosomal recessive mutations in the SMARCD2 gene. Methods Prenatal screening in our patient revealed a novel homozygous nonsense mutation in SMARCD2 (c.208C>T, p.Gln70*).
Michelle A. E. Brouwer, Arie Arensman, H. Rob Taal, Emilie P. Buddingh, Su Ming Sun, Anthon Hulsmann, Lenneke Waals‐Prinzen   +6 more
wiley   +1 more source

Pneumonia por Rhodococcus equi em doente VIH (+): A propósito de uma associação rara Rhodococcus equi pneumonia in a HIV (+) patient: An uncommon association

Revista Portuguesa de Pneumologia, 2007
A infecção humana por Rhodococcus equi, mesmo no contexto da infecção pelo VIH, é relativamente rara. Os autores apresentam o caso clínico de um indivíduo, infectado pelo VIH, que apresentava um quadro clínico e imagiológico compatível com pneumonia ...
Paula Esteves, Ana Mineiro, Margarida Serrado, António Diniz   +3 more
doaj  

Antimicrobial prescribing guidelines for horses in Australia

Australian Veterinary Journal, Volume 103, Issue 12, Page 781-889, December 2025.
The growing problem of antimicrobial resistance also affects equine veterinarians with increasing frequency. Antimicrobial stewardship and responsible prescribing are essential for a future in which effective antimicrobials are available, as it is unlikely that new antimicrobials will become available for use in horses.
L Hardefeldt, K Thomas, S Page, J Norris, G Browning, C El Hage, A Stewart, J Gilkerson, G Muscatello, D Verwilghen, G van Galen, J Bauquier, R Cuming, B Reynolds, C Whittaker, E Wilkes, J Clulow, C Burden, L Begg   +18 more
wiley   +1 more source

Tear Film Osmolarity in Horses With Bacterial Conjunctivitis

Veterinary Medicine and Science, Volume 11, Issue 6, November 2025.
This study evaluated tear film osmolarity in horses with bacterial conjunctivitis. Although osmolarity values were higher in affected horses compared to healthy ones, the difference was not statistically significant. These findings highlight the need for further research before tear osmolarity can be considered a reliable diagnostic marker in equine ...
Ahad Saberinia, Saeed Ozmaei, Amin Anoushepour   +2 more
wiley   +1 more source

ENDOSCOPIC AND SURGICAL INTERVENTION OF COMPLETE ESOPHAGEAL STRICTURE IN A ONE-MONTH-OLD THOROUGHBRED FOAL WITH Rhodococcus equi PNEUMONIA

Slovenian Veterinary Research
This case report describes a surgical and endoscopic approach for treating a complete esophageal stricture in a one-month-old Thoroughbred foal with Rhodococcus equi pneumonia.
Jungho Yoon, Ahram Kim, Jeonghun Lee, In-Soo Choi, Taemook Park   +4 more
doaj   +1 more source

Rhodococcus equi Parte 2: imunologia e profilaxia Rhodococcus equi Part 2: immunology and profilaxy

Ciência Rural, 2011
Rhodococcus equi é um patógeno ubíquo e habitante da flora intestinal dos equinos de importância na neonatologia equina. Todos os potros são expostos à doença ao nascimento, porém alguns a desenvolvem e outros não.
Ana Carolina Rusca Correa Porto, Wilson Roberto Fernandes, Maria Cristina Roque Barreira   +2 more
doaj   +1 more source