Results 121 to 130 of about 61,046 (231)

Breaking quantum linearity: constraints from human perception and cosmological implications

, 2010
Resolving the tension between quantum superpositions and the uniqueness of the classical world is a major open problem. One possibility, which is extensively explored both theoretically and experimentally, is that quantum linearity breaks above a given ...
A. Bassi, Adler S. L., Adler S. L., Adler S. L., Adler S. L., Bassi A., Bell J. S., Carlip S., D.-A. Deckert, Feynman R. P., Grishchuk L. P., Kandel E. R., Khárolyázi F., L. Ferialdi, Nicholls J. G., Pugh E. N. J.   +15 more
core   +1 more source

Retinal Pigment Epitheliopathy due to Sub‐Optimal Recycling of Vitamin A (RESORVA): A Novel RDH11 ‐Related Phenotype

Clinical Genetics, Volume 109, Issue 5, Page 972-977, May 2026.
RDH11 is a minor isoenzyme that catalyses the oxidation of 11‐cis‐retinol to 11‐cis‐retinal in the retinal pigment epithelium, alongside RDH5 and RDH10. Biallelic null variants in RDH11 lead to upregulation of RDH5 and RDH10 (transcriptional adaptation), maintaining 11‐cis‐retinal bioavailability, but still causing Retinal Pigment Epitheliopathy due to
Kirk A. J. Stephenson, Zhuo Shao, Anupreet Tumber, Erika Tavares, Kashif Ahmed, Edward J. Higginbotham, Christian R. Marshall, Jason T. Maynes, Ammaji Rajala, Raju V. S. Rajala, Elise Héon, Ajoy Vincent   +11 more
wiley   +1 more source

Cells and ionic conductances contributing to spontaneous activity in bladder and urethral smooth muscle

The Journal of Physiology, Volume 604, Issue 9, Page 3611-3632, 1 May 2026.
Abstract figure legend Cells and conductances contributing to spontaneous activity in the lower urinary tract. Bladder and urethra exhibit spontaneous contractions at both cellular and tissue levels. Both detrusor and urethral smooth muscle cells display activity that is regular and rhythmic.
Bernard T. Drumm, Neha Gupta, Alexandru Mircea, Caoimhin S. Griffin   +3 more
wiley   +1 more source

Maternal plasma docosahexaenoic acid (DHA) concentrations increase at the critical time of neural tube closure [PDF]

, 2017
No abstract ...
Freeman, Dilys J., Meyer, Barbara J.
core  

Struktureller Mechanismus eines Aktivitäts‐Photoschalters am β2‐adrenergen Rezeptor

Angewandte Chemie, Volume 138, Issue 18, 27 April 2026.
Zeitaufgelöste Strukturen aus Messungen an Röntgen‐Freie‐Elektronen‐Lasern in Kombination mit zellulären Assays zeigen, wie der photoschaltbare β‐Blocker Photoazolol‐1 als Wirksamkeits‐Photoschalter der Funktion des β2‐adrenergen Rezeptor wirkt. Die lichtinduzierte Neupositionierung des Liganden verschiebt die Aktivität von inversem Agonistimus hin zu ...
Robin Stipp, Quentin Bertrand, Matilde Trabuco, Anna Duran‐Corbera, Maria Tindara Ignazzitto, Hannah Glover, Fabienne Stierli, Juanlo Catena, Melissa Carrillo, Sina Hartmann, Hans‐Peter Seidel, Matthias Mulder, Thomas Mason, Yasushi Kondo, Maximillian Wranik, Martin Appleby, Christoph Sager, Raymond Sierra, Gregory Gate, Pamela Schleissner, Xinxin Cheng, Tobias Weinert, Robert Cheng, Sandra Mous, John H. Beale, Michal Kepa, Amadeu Llebaria, Michael Hennig, Xavier Rovira, Joerg Standfuss   +29 more
wiley   +1 more source

Equivalence of background and bleaching desensitization in isolated rod photoreceptors of the larval tiger salamander. [PDF]

, 1996
Psychophysical experiments have shown an equivalence between sensitivity reduction by background light and by bleaches for the human scotopic system.
Cornwall, MC, Fain, GL, Jones, GJ
core  

Structural Mechanism of an Efficacy Photoswitch Targeting the β2‐adrenergic Receptor

Angewandte Chemie International Edition, Volume 65, Issue 18, 27 April 2026.
Time‐resolved structures from x‐ray free‐electron laser measurements combined with cellular assays demonstrate how the photoswitchable β‐blocker photoazolol‐1 acts as an efficacy switch of β2‐adrenergic receptor function. Light‐induced ligand repositioning shifts activity from inverse agonism toward neutral antagonism by altering local helical ...
Robin Stipp, Quentin Bertrand, Matilde Trabuco, Anna Duran‐Corbera, Maria Tindara Ignazzitto, Hannah Glover, Fabienne Stierli, Juanlo Catena, Melissa Carrillo, Sina Hartmann, Hans‐Peter Seidel, Matthias Mulder, Thomas Mason, Yasushi Kondo, Maximillian Wranik, Martin Appleby, Christoph Sager, Raymond Sierra, Gregory Gate, Pamela Schleissner, Xinxin Cheng, Tobias Weinert, Robert Cheng, Sandra Mous, John H. Beale, Michal Kepa, Amadeu Llebaria, Michael Hennig, Xavier Rovira, Joerg Standfuss   +29 more
wiley   +1 more source

The Conformational Switches of a Bacterial Light‐Driven Sodium Pump Characterized by Time‐Resolved Resonance Raman Spectroscopy

ChemPhysChem, Volume 27, Issue 7, 14 April 2026.
The microbial retinal protein KR2 (Krokinobacter eikastus) is a light‐driven outward Na+ pump, which is coupled to the photocycle of the chromophore. Using time‐resolved continuous‐wave pump‐probe resonance Raman spectroscopy, the operational switches for ion transport are identified, which are the transitions to a specific Schiff base sub‐state and ...
Anna Lena Schäfer, Arita Silapetere, Peter Hegemann, Katrina T. Forest, Uwe Kuhlmann, Peter Hildebrandt   +5 more
wiley   +1 more source

Tauroursodeoxycholic acid binds to the G-protein site on light activated rhodopsin [PDF]

, 2018
Kisselev, O. G, Lobysheva, E., Marshall, G. R, Taylor, C. M   +3 more
core   +2 more sources

Super-resolution mapping in rod photoreceptors identifies rhodopsin trafficking through the inner segment plasma membrane as an essential subcellular pathway.

PLoS Biology
Photoreceptor cells in the vertebrate retina have a highly compartmentalized morphology for efficient phototransduction and vision. Rhodopsin, the visual pigment in rod photoreceptors, is densely packaged into the rod outer segment sensory cilium and ...
Kristen N Haggerty, Shannon C Eshelman, Lauren A Sexton, Emmanuel Frimpong, Leah M Rogers, Melina A Agosto, Michael A Robichaux   +6 more
doaj   +1 more source