Results 101 to 110 of about 38,017 (242)

Mutation-independent treatment of autosomal dominant Retinitis Pigmentosa (adRP)

, 2010
Viral-mediated gene therapy holds great promise for the treatment of severe inherited retinal diseases, such as Retintitis Pigmentosa (RP), which is caused by mutations in genes preferentially expressed in photoreceptor cells. The availability of vectors
Mussolino, Claudio
core  

Robust Endoplasmic Reticulum-Associated Degradation of Rhodopsin Precedes Retinal Degeneration [PDF]

, 2015
Rhodopsin is a G protein-coupled receptor essential for vision and rod photoreceptor viability. Disease-associated rhodopsin mutations, such as P23H rhodopsin, cause rhodopsin protein misfolding and trigger endoplasmic reticulum (ER) stress, activating ...
Kroeger, H, Kroeger, Heike, Lin, Jonathan H, Chiang, WC, Coppinger, JA, Palczewski, K, Palczewski, Krzysztof, LaVail, MM, Lin, JH, Sakami, S, Messah, C, Yasumura, Douglas, Matthes, MT, LaVail, Matthew M, Sakami, Sanae, Yasumura, D, Matthes, Michael T, Messah, Carissa, Coppinger, Judith A, Chiang, Wei-Chieh   +19 more
core   +1 more source

Eye Development in Sepia officinalis Embryo: What the Uncommon Gene Expression Profiles Tell Us about Eye Evolution

Frontiers in Physiology, 2017
In metazoans, there is a remarkable diversity of photosensitive structures; their shapes, physiology, optical properties, and development are different.
Boudjema Imarazene, Aude Andouche, Yann Bassaglia, Yann Bassaglia, Pascal-Jean Lopez, Laure Bonnaud-Ponticelli   +5 more
doaj   +1 more source

Studies in rhodopsin. 4. Preparation of rhodopsin [PDF]

Biochemical Journal, 1952
F D, COLLINS, R M, LOVE, R A, MORTON
openaire   +2 more sources

Nano‐Gs‐Protein Peptidomimetika: Rationales Design von Peptiden, die vom C‐Terminus von Gα abgeleitet sind und Schlüsselkomponenten der Gs‐β2AR‐Wechselwirkungen nachahmen

Angewandte Chemie, Volume 138, Issue 24, 8 June 2026.
G Protein‐gekoppelte Rezeptoren (GPCRs) sind wichtige therapeutische Zielstrukturen. Die Modulation der GPCR‐Aktivität über intrazelluläre Bindungsstellen gewinnt zunehmend an Bedeutung. Ein strukturell und computergestützter Ansatz ermöglichte die Entwicklung kleiner, vom G Protein abgeleiteter Peptidomimetika, die gezielt an die intrazelluläre ...
Phuong Thu Tran, Mia Danielsen, Johanna K. S. Tiemann, Passainte Ibrahim, Søren G. F. Rasmussen, Xavier Kubiak, Hossein Batebi, Charlène Gadais, Steven Ballet, Peter W. Hildebrand, Daniel Sejer Pedersen, Jesper Mosolff Mathiesen   +11 more
wiley   +1 more source

Different amino acid substitutions at the same position in rhodopsin lead to distinct phenotypes

, 2006
PURPOSE: Identification of a novel rhodopsin mutation in a family with retinitis pigmentosa and comparison of the clinical phenotype to a known mutation at the same amino acid position.
Neidhardt, John, Neidhardt, J, Fleischhauer, Johannes C, Berger, W, Farahmand, Firouzeh, Farahmand, F, Berger, Wolfgang, Barthelmes, D, Fleischhauer, J C, Barthelmes, Daniel   +9 more
core   +1 more source

Nano‐Gs Protein Peptidomimetics: Rational Design of Gα C‐Terminus‐Derived Peptides Mimicking Key Components of Gs‐β2AR Interactions

Angewandte Chemie International Edition, Volume 65, Issue 24, 8 June 2026.
G protein‐coupled receptors (GPCRs) are major therapeutic targets. Modulating GPCR activity through intracellular sites is evolving. A structure‐ and computation‐assisted approach generated small G protein‐derived peptidomimetics targeting the intracellular binding crevice of the β2 adrenergic receptor mimicking features of the full G protein.
Phuong Thu Tran, Mia Danielsen, Johanna K. S. Tiemann, Passainte Ibrahim, Søren G. F. Rasmussen, Xavier Kubiak, Hossein Batebi, Charlène Gadais, Steven Ballet, Peter W. Hildebrand, Daniel Sejer Pedersen, Jesper Mosolff Mathiesen   +11 more
wiley   +1 more source

dPob/EMC is essential for biosynthesis of rhodopsin and other multi-pass membrane proteins in Drosophila photoreceptors

eLife, 2015
In eukaryotes, most integral membrane proteins are synthesized, integrated into the membrane, and folded properly in the endoplasmic reticulum (ER).
Takunori Satoh, Aya Ohba, Ziguang Liu, Tsuyoshi Inagaki, Akiko K Satoh   +4 more
doaj   +1 more source

Wave Mechanics of Ciliary Proteins: Quantum‐Enabled Sensing and Energy Transfer in the “Cellular Antenna”

Aggregate, Volume 7, Issue 6, June 2026.
This review surveys eukaryotic cilia as putative quantum‐enabled sensory and regulatory centers. It highlights their multifaceted roles in the cell, focuses on the nontrivial roles of quantum mechanics in their membrane and cytoskeletal proteins, and introduces the essential building blocks enabling quantum properties to survive in the warm, wet, and ...
Daniel L. Bilezikian, Dylan Davidoff, Justin R. Caram, Thomas P. Fay, Aarat P. Kalra, Paul S. Weiss   +5 more
wiley   +1 more source

Rhodopsin was expressed in NHEKs.

, 2013
(A) NHEKs were transiently transfected with pcDNA3.1 empty vector (left lane) or rhodopsin expression vector (right lane) for 48 hr and then analyzed by Western blot.
Eui Dong Son (459815), Hyoung-June Kim (459814), Ji-Yong Jung (459816), Hyun Choi (459817), Tae Ryong Lee (433037), Dong Wook Shin (176902)   +5 more
core   +1 more source