Results 111 to 120 of about 61,046 (231)

dPob/EMC is essential for biosynthesis of rhodopsin and other multi-pass membrane proteins in Drosophila photoreceptors

eLife, 2015
In eukaryotes, most integral membrane proteins are synthesized, integrated into the membrane, and folded properly in the endoplasmic reticulum (ER).
Takunori Satoh, Aya Ohba, Ziguang Liu, Tsuyoshi Inagaki, Akiko K Satoh   +4 more
doaj   +1 more source

Comparative Analysis Reveals the Adaptive Evolution of Olfactory System in the Swamp Eel (Monopterus albus) Based on the Chromosome‐Level Genome

Ecology and Evolution, Volume 16, Issue 5, May 2026.
A total of 629 gene families were identified to expand in the swamp eel, with five (OLFR, GNAL, PRKG1, NCALD, and PDE1) distributed in olfactory transduction (KEGG map04740). A total of 318 OR genes (289 functional genes, 10 partial genes, and 19 pseudogenes) were annotated in the swamp eel genome, significantly surpassing other fish species.
Chuang Zhou, Zhongyi Wang, Chenhao Zhang, Zhaobin Song   +3 more
wiley   +1 more source

Circadian rhythms in the Drosophila eye may regulate adaptation of vision to light intensity

Frontiers in Neuroscience
The sensitivity of the eye at night would lead to complete saturation of the eye during the day. Therefore, the sensitivity of the eye must be down-regulated during the day to maintain visual acuity.
Richard Brent Nolan, Jin-Yuan Fan, Jeffrey L. Price   +2 more
doaj   +1 more source

Sphingosine‐1‐Phosphate Receptor 3 Confers Tumor Metastasis in Lung Cancer Resistant to Third‐Generation EGFR Inhibitor

MedComm, Volume 7, Issue 5, May 2026.
• S1PR3 drives metastasis in EGFR TKI‐resistant lung cancer by activating RAC1‐PAK1 signaling and promoting EMT. • FGFR1‐STAT4 axis upregulates S1PR3, enabling metastatic escape in resistant tumors. • Targeting S1PR3 or FGFR1 suppresses metastasis, offering a therapeutic strategy for EGFR TKI‐resistant lung cancer.
Mengzhen Lai, Jiaying Chen, Ye Qin, Hui Zhang, Zilu Pan, Tao Zhang, Linjiang Tong, Haotian Tang, Gang Bai, Qiupei Liu, Yan Li, Fang Feng, Peiran Song, Yingqiang Liu, Yi Chen, Yan Fang, Bencan Tang, Meiyu Geng, Ker Yu, Hao Chen, Jian Ding, Hua Xie   +21 more
wiley   +1 more source

Mutant dominant-negative rhodopsin∆I256 causes protein aggregates degraded via ERAD and prevents normal rhodopsin from proper membrane trafficking

Frontiers in Molecular Biosciences
Dominant mutations in the rhodopsin gene (Rho) contribute to 25% of autosomal dominant retinitis pigmentosa (adRP), characterized by photoreceptor loss and progressive blindness. One such mutation, Rho∆I256, carries a 3-bp deletion, resulting in the loss
Bowen Cao, Bowen Cao, Johanna Valentina Dahlen, Merve Sen, Merve Sen, Tina Beyer, Tobias Leonhard, Ellen Kilger, Blanca Arango-Gonzalez, Marius Ueffing   +9 more
doaj   +1 more source

Deep Proteomic Profiles of the Antarctic Diatom Fragilariopsis Cylindrus Under Varying Iron and Manganese Conditions

PROTEOMICS, Volume 26, Issue 5, Page 112-119, May 2026.
ABSTRACT Fragilariopsis cylindrus is a key diatom in the Southern Ocean, where low iron and manganese availability constrain primary production and biogeochemical activity. The molecular mechanisms used by polar diatoms, including F. cylindrus, to cope with trace metal limitations remain largely unexplored.
Loay J. Jabre, Elden Rowland, J. Scott P. McCain, Erin M. Bertrand   +3 more
wiley   +1 more source

Studies in rhodopsin. 4. Preparation of rhodopsin [PDF]

Biochemical Journal, 1952
F D, COLLINS, R M, LOVE, R A, MORTON
openaire   +2 more sources

Shine Amidst Darkness—A Case of Oguchi Disease

TNOA Journal of Ophthalmic Science and Research
An 11-year-old boy presented with complaints of defective night vision. Visual acuity was 6/6 in both eyes. The fundus showed a golden-to-grey discoloration in light and on dark adaptation, the fundus reverted to its normal appearance demonstrating the ...
R Padmapriya, Fathima Fahima Akbar
doaj   +1 more source

Folding, misfolding, and regulation of intracellular traffic of G protein‐coupled receptors involved in the hypothalamic–pituitary–gonadal axis

Andrology, Volume 14, Issue 4, Page 978-991, May 2026.
Abstract Background G protein‐coupled receptors are a large and functionally diverse family of membrane receptors involved in a number of biological processes. Like other proteins, G protein‐coupled receptors need to be properly folded in order to traffic to the plasma membrane and interact with agonist.
Alfredo Ulloa‐Aguirre, Ross C. Anderson, Teresa Zariñán, Rubén Gutiérrez‐Sagal, Eduardo Jardón‐Valadez, Claire L. Newton   +5 more
wiley   +1 more source

Localization and dimer stability of a newly identified microbial rhodopsin from a polar, non-motile green algae

BMC Research Notes, 2018
Objective The eukaryotic plasma membrane localized light-gated proton-pumping rhodopsins possesses great optogenetic applications for repolarization (silencing) of the neuronal activity simply by light illumination.
Peeyush Ranjan, Suneel Kateriya
doaj   +1 more source