Results 91 to 100 of about 38,017 (242)

A Multi-Scale–Multi-Stable Model for the Rhodopsin Photocycle

Molecules, 2014
We report a multi-scale simulation study of the photocycle of the rhodopsins. The quasi-atomistic representation (“united atoms” UA) of retinal is combined with a minimalist coarse grained (CG, one-bead-per amino acid) representation of the protein, in a
Francesco Tavanti, Valentina Tozzini
doaj   +1 more source

Advances in cardiac devices and bioelectronics augmented with artificial intelligence

The Journal of Physiology, EarlyView.
Abstract figure legend Interfaces between the human heart, diagnostic bioelectronics, artificial intelligence, and clinical care. From left to right: Human heart and biosensor interface; representative waveforms of common diagnostic bioelectronic sensing modalities.
Charles Stark, Eric Rytkin, Andrei Alexandru Mircea, Igor R. Efimov   +3 more
wiley   +1 more source

Efficient coupling of transducin to monomeric rhodopsin in a phospholipid bilayer

, 2008
G protein-coupled receptors (GPCRs) are seven transmembrane domain proteins that transduce extracellular signals across the plasma membrane and couple to the heterotrimeric family of G proteins. Like most intrinsic membrane proteins, GPCRs are capable of
Dimitrios Fotiadis, Sunahara, Roger K, Park, Paul S-H, Whorton, M. R., Whorton, Matthew R, Fotiadis, D., Jastrzebska, B., Palczewski, K., Palczewski, Krzysztof, Roger K. Sunahara, Fotiadis, Dimitrios, Beata Jastrzebska, Matthew R. Whorton, Engel, Andreas, Jastrzebska, Beata, Engel, A., Krzysztof Palczewski, Park, P. S., Paul S.-H. Park, Andreas Engel, Sunahara, R. K.   +20 more
core   +1 more source

Therapeutic potential of archaeal unfoldase PANet and the gateless T20S proteasome in P23H rhodopsin retinitis pigmentosa mice.

PLoS ONE
Neurodegenerative diseases are characterized by the presence of misfolded and aggregated proteins which are thought to contribute to the development of the disease.
Celine Brooks, Douglas Kolson, Emily Sechrest, Janelle Chuah, Jane Schupp, Neil Billington, Wen-Tao Deng, David Smith, Maxim Sokolov   +8 more
doaj   +1 more source

Differential effects of lipid composition on the thermal and functional properties of membrane associated CYP2J2

Protein Science, Volume 35, Issue 7, July 2026.
Abstract CYP2J2 is a membrane‐bound cytochrome P450 that is expressed in cardiomyocytes, where it is known to metabolize arachidonic acid into cardioprotective epoxyeicosatrienoic acids (EETs). It consists of transmembrane domains embedded in the hydrophobic segments of the cell membrane and surrounded by various lipids.
Rajatabha Das, Henry M. Mastrion, Harrison B. Vassar, Aditi Das   +3 more
wiley   +1 more source

Rhodopsin expression in mice with various numbers of rhodopsin genes.

, 2013
(A) Northern blot analysis of rhodopsin mRNA from various mouse lines. Copy numbers of wild type rhodopsin and P23H-rhodopsin genes are indicated below each lane, where mRho 0 is mRho−/−, mRho 1 is mRho+/−, mRho 2 is mRho+/+, and mRho 0 NHRE 2 is mRho ...
Ramon Roman-Sanchez (297765), Ivette M. Sandoval (297759), Theodore G. Wensel (87573), Ralph Nichols (297763), Brandee A. Price (297757), Fung Chan (297761), John H. Wilson (297768)   +6 more
core   +1 more source

Drugs that act on both G protein‐coupled receptors (GPCRs) and kinases: potentiation of effects, side effects and general aspects of drug pleiotropy

British Journal of Pharmacology, Volume 183, Issue 13, Page 3471-3483, July 2026.
Abstract Background A drug designed for a specific target often interacts with multiple targets, either unintentionally or as part of its intended mechanism of action. This has been called pharmacological pleiotropy or polypharmacology. There are key endogenous ligands such as ATP, GABA and glutamate that act on various proteins in humans. Furthermore,
Hampus Ljunggren, Aleksandr Sokolov, Flavio Ballante, Robert Fredriksson, Francisco Lagunas‐Rangel, Alexander S. Hauser, Stefan Knapp, Jörgen Jonsson, Helgi B. Schiöth   +8 more
wiley   +1 more source

Rhodopsin 7-The unusual Rhodopsin in Drosophila

, 2020
Rhodopsins are the major photopigments in the fruit fly Drosophila melanogaster. Drosophila express six well-characterized Rhodopsins (Rh1-Rh6) with distinct absorption maxima and expression pattern.
Pingkalai R Senthilan, Charlotte Helfrich-Förster   +1 more
core  

High levels of rhodopsin phosphorylation in missense mutations of C-terminal region of rhodopsin

, 1997
Rhodopsin phosphorylation was investigated using synthetic C-terminal peptides from rhodopsin. The peptides were phosphorylated by expressed rhodopsin kinase (RK) in the presence of a photolyzed truncated rhodopsin at the C-terminus.
Hiroshi Ohguro, Ohguro, Hiroshi
core   +1 more source

Microbial Metabolite‐Stimulated Bitter Taste Receptor T2R14 Signaling Is Modulated by CFTR Interactions

The FASEB Journal, Volume 40, Issue 11, 15 June 2026.
Bitter taste receptors (T2Rs) play an important role in physiological and cellular responses. Bitter tasting chemicals and microbial metabolites can bind to T2R14, which enables interactions between T2R14 and specific intracellular domains of the cystic fibrosis transmembrane conductance regulator (CFTR) anion channel.
Tejas Gupte, Nisha Singh, Vikram Bhatia, Kavisha Arora, Shayan Amiri, Paul Fernyhough, Anjaparavanda P. Naren, Shyamala Dakshinamurti, Prashen Chelikani   +8 more
wiley   +1 more source