Results 191 to 200 of about 581,735 (300)

Hippocampal Seizure‐Related Burden is Associated with Accelerated Long‐Term Forgetting in Focal Epilepsy

Annals of Neurology, EarlyView.
Objective Memory impairment is a frequent comorbidity of focal epilepsy, incompletely explained by seizure frequency or structural pathology. Ictal and postictal hippocampal dysfunction disrupt memory processes, but their cumulative impact remains poorly quantified.
Ionuț‐Flavius Bratu, Isabelle Lambert, Olivier Felician, Samuel Medina Villalon, Agnès Trébuchon, Fabrice Bartolomei   +5 more
wiley   +1 more source

Stokes-Adams Syncope and Ventricular Standstill. [PDF]

J Arrhythm
Shakfeh K, Yamada T, Saini A.
europepmc   +1 more source

Von In‐Silico bis In‐Cerebro – Entwicklung des Orexinrezeptor Antagonisten „Photorexant“ zur Photomodulation In Vitro und im Gehirn der Maus

Angewandte Chemie, EarlyView.
Durch einen strukturbasierten Designansatz wurden photoschaltbare Derivate des von der FDA zugelassenen Arzneistoffes Suvorexant entwickelt, gedockt, synthetisiert und pharmakologisch an den Orexin‐1‐ und 2‐Rezeptoren (OX1R und OX2R) charakterisiert.
Marcus Angermann, Marie H. Deventer, Vicente Ledesma‐Martin, Nuno Martinho, Alix Flake, Silvia Mori, Angel Nuñez, Jaime Pignatelli, Rita C. Guedes, Christophe P. Stove, Michael Decker   +10 more
wiley   +1 more source

Interactions of blood biomolecules with early rhythm control in atrial fibrillation patients: exploratory analysis of the EAST-AFNET 4 biomolecule study. [PDF]

Europace
Al-Taie C, Obergassel J, Borof K, Ridder J, Rillig A, Metzner A, Goette A, Magnussen C, Sinner MF, Sommerfeld LC, Willems S, Zeller T, Schnabel RB, Schotten U, Zapf A, Kirchhof P, Fabritz L.   +16 more
europepmc   +1 more source

In Silico to In Cerebro—Development of the Orexin Receptor Antagonist “Photorexant” for Photomodulation In Vitro and in Mouse Brains

Angewandte Chemie International Edition, EarlyView.
Following a structure‐based design approach, photoswitchable derivatives of the FDA‐approved drug suvorexant were designed, docked, synthesized, and characterized pharmacologically at the orexin 1 and 2 receptors (OX1R and OX2R). Optimized “photorexant” showed up to an 11‐fold difference in IC50 between photoisomers, enabled dynamic and reversible ...
Marcus Angermann, Marie H. Deventer, Vicente Ledesma‐Martin, Nuno Martinho, Alix Flake, Silvia Mori, Angel Nuñez, Jaime Pignatelli, Rita C. Guedes, Christophe P. Stove, Michael Decker   +10 more
wiley   +1 more source

A review of the impact of circadian rhythm on motor function in stroke recovery patients. [PDF]

Front Neurol
Zhou H, Zhang T, Li B, Zhao J.
europepmc   +1 more source

Proto‐Panic Modulation by Caffeine‐Proteinoid Complexes

Journal of Applied Polymer Science, EarlyView.
Caffeine–proteinoid microspheres synthesized by thermal polymerization exhibit compartmentalized drug loading with encapsulation efficiencies of 61%–82% and triphasic release kinetics. Electrochemical monitoring reveals multi‐scale oscillatory dynamics consistent with chaotic and damped harmonic behavior, while Boolean logic operations demonstrate ...
Panagiotis Mougkogiannis, Andrew Adamatzky   +1 more
wiley   +1 more source

Asymptomatic Atrial Fibrillation in Contemporary Clinical Practice: Insights from the REGUEIFA Registry. [PDF]

Med Sci (Basel)
Minguito-Carazo C, González Melchor L, Vázquez Caamaño M, Fernández-Obanza Windcheid E, Marzoa R, Piñeiro Portela M, González Babarro E, Cabanas Grandío P, Durán Bobín O, Prada Delgado Ó, Tejada JE, Freire E, Gutiérrez Feijoo M, Muñiz J, Gude F, Barge Caballero E, González-Juanatey C, García Seara J.   +17 more
europepmc   +1 more source

Growth dynamics, skeletochronology, and histovariability of the theropod dinosaur Berthasaura leopoldinae

The Anatomical Record, EarlyView.
Osteohistological sampling on different bones of theropod dinosaur documents discrepant age record, growth, and metabolism. This could result unprecise paleobiological inferences if samplings are based on single bones. However, multi‐bone sampling can attenuate these discrepancies, helping to infer growth dynamics and physiology of these extinct ...
Geovane Alves de Souza, Marina Bento Soares, Luiz Carlos Weinschütz, Alexander Wilhelm Armin Kellner   +3 more
wiley   +1 more source