Results 41 to 50 of about 265,325 (306)

Control of skin cancer by the circadian rhythm [PDF]

Proceedings of the National Academy of Sciences, 2011
Skin cancer is the most common form of cancer in the United States. The main cause of this cancer is DNA damage induced by the UV component of sunlight. In humans and mice, UV damage is removed by the nucleotide excision repair system. Here, we report that a rate-limiting subunit of excision repair, the xeroderma pigmentosum group A (XPA) protein, and ...
Gaddameedhi, Shobhan, Selby, Christopher P, Kaufmann, William K, Smart, Robert C, Sancar, Aziz   +4 more
openaire   +3 more sources

Effects of environmental enrichment on behavioral responses to novelty, learning, and memory, and the circadian rhythm in cortisol in growing pigs [PDF]

, 2000
Previously we showed that pigs reared in an enriched environment had higher baseline salivary cortisol concentrations during the light period than pigs reared under barren conditions.
Prelle, Ina T.,, Lambooij, E., Korte, S.M., Blokhuis, Harry J., Burgwal, Johan A. van de,, Korte, S. Mechiel, Lambooij, Elbert,, Prelle, Ina T., Blokhuis, H.J., Koolhaas, J.M., van de Burgwal, J.A., Lambooij, Elbert, Blokhuis, Harry J.,, Jong, I.C., de, Koolhaas, Jaap M.,, de Jong, Ingrid C., Burgwal, J.A., van de, Koolhaas, Jaap M., Prelle, I.T., Korte, S. Mechiel,, Jong, Ingrid C. de,, de Jong, I.C., van de Burgwal, Johan A.   +22 more
core   +1 more source

PARK(ing) time–How park deficiency affects the biological clock in a Drosophila model of Parkinson's disease

FEBS Letters, EarlyView.
Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara, Kinga Skoczek, Elzbieta Pyza, Milena Damulewicz   +3 more
wiley   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

2020 ESC Guidelines for the diagnosis and management of atrial fibrillation developed in collaboration with the European Association for Cardio-Thoracic Surgery (EACTS)

Российский кардиологический журнал, 2021
2020 ESC Guidelines for the diagnosis and management of atrial fibrillation developed in collaboration with the European Association for Cardio-Thoracic Surgery (EACTS)
G. Hindricks, T. Potpara, N. Dagres, E. Arbelo, J. J. Bax, C. Blomstrӧm-Lundqvist, G. Boriani, M. Castella, G.-A. Dan, P. E. Dilaveris, L. Fauchier, G. Filippatos, J. M. Kalman, M. La Meir, D. A. Lane, J.-P. Lebeau, M. Lettino, G. Y.H. Lip, F. J. Pinto, G. Neil Thomas, M. Valgimigli, I. C. Van Gelder, B. P. Van Putte,, C. L. Watkins   +23 more
doaj   +1 more source

Super‐Refractory Status Epilepticus (SRSE) in a Patient With Compound Heterozygous OPA1 Variants: Case Report and Literature Review

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi, Lara Basovic, Christopher Michael McGraw   +2 more
wiley   +1 more source

Intravenous Cavutilide for Pharmacological Conversion of Paroxysmal and Persistent Atrial Fibrillation in Patients with Heart Failure

Journal of Cardiovascular Development and Disease, 2023
This work aimed to study the efficacy and safety of the class III antiarrhythmic agent cavutilide (Niferidil, Refralon) for pharmacological cardioversion in patients with paroxysmal and persistent atrial fibrillation (AF) and heart failure (HF).
Maria M. Beliaeva, Khava M. Dzaurova, Yulia A. Yuricheva, Peter S. Novikov, Nikolay Yu. Mironov, Gennady S. Tarasovskiy, Maksim A. Zelberg, Sergey F. Sokolov, Sergey P. Golitsyn   +8 more
doaj   +1 more source

Adaptive control of cardiac rhythms

Scientific Reports
Cardiac rhythms are related to heart electrical activity, being the essential aspect of the cardiovascular physiology. Usually, these rhythms are represented by electrocardiograms (ECGs) that are useful to detect cardiac pathologies. Essentially, the heart activity starts in the sinoatrial node (SA) node, the natural pacemaker, propagating to the ...
Gabriel da Silva Lima, Marcelo Amorim Savi, Wallace Moreira Bessa   +2 more
openaire   +3 more sources

Validity of a Wearable Digital Insole for Assessing Gait ON and OFF in Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Gait impairment is a distinctive symptom of Parkinson's disease that negatively impact mobility. We assessed the validity of wearable digital insoles against a validated reference gait analysis system for measuring select gait characteristics in patients with Parkinson's disease. Methods A comparative analysis between digital insoles
Deborah A. Hall, Kimberly Kwei, Rolando J. Acosta, Bharatkumar Koyani, Erin Robertson, Pratyush Rai, Roland Barge, Emily Timm, Nicollette L. Purcell, Natasha Desai, Dhanesh Patel, Ana‐Maria Visoiu‐Knapp, Samuel Stuart, Rinol Alaj, Matthew F. Wipperman, Oren Levy, Joan A. O'Keefe   +16 more
wiley   +1 more source

Revitalizing brain perfusion: Unveiling advancements through rhythm control strategies in atrial fibrillation—A systematic review

Journal of Arrhythmia
Background Recent evidence suggests an elevated risk of cognitive impairment and dementia in individuals with atrial fibrillation (AF), irrespective of stroke occurrence. AF, known to reduce brain perfusion, particularly through silent cerebral ischemia,
Shinta Dewi Rasti, Adra Achirultan Ramainaldo Sugiarto, Audia Putri Amalia Nuryandi, Militanisa Zamzara Arvianti, Romadhana Trisnha Yomara, Jeffri Nagasastra, Rerdin Julario, Rosi Amrilla Fagi, Diah Mustika Hesti Windrati   +8 more
doaj   +1 more source