Results 91 to 100 of about 76,496 (274)

What future for ribavirin? [PDF]

Liver International, 2009
AbstractThe optimal therapy for patients with the chronic hepatitis C virus (HCV) is a combination of peginterferon and ribavirin. Treating HCV without ribavirin or prematurely discontinuing, frequently missing doses of ribavirin is associated with a significant decline in virological response, and an increase in both breakthrough viraemia and relapse.
openaire   +3 more sources

Respiratory Syncytial Virus Exceeded SARS‐CoV‐2 and Influenza in Lower Respiratory Infection and Mortality Rates Among Patients With Hematologic Malignancies During the 2023–2024 Respiratory Virus Season

Transplant Infectious Disease, EarlyView.
During the 2023‐2024 respiratory viral season, respiratory syncytial virus infection was associated with worse outcomes compared to infections caused by SARS‐CoV‐2 and influenza virus in patients with hematologic malignancies ABSTRACT Background Respiratory viral infections (RVIs) significantly impact patients with hematologic malignancies (HMs ...
Tali Shafat, Amy Spallone, Fareed Khawaja, Ying Jiang, Jennifer Jackson, Lior Nesher, Roy F. Chemaly   +6 more
wiley   +1 more source

Ribavirin Induces Polyamine Depletion via Nucleotide Depletion to Limit Virus Replication

Cell Reports, 2019
Summary: Common antivirals include nucleoside or nucleotide analogs with base prodrugs. The antiviral ribavirin, a US Food and Drug Administration (FDA)-approved nucleoside antimetabolite, halts guanine production, mutagenizes viral genomes, and ...
Patrick M. Tate, Vincent Mastrodomenico, Bryan C. Mounce   +2 more
doaj   +1 more source

A Case of Obstructive Jaundice due to Bile Duct Tumor Thrombus of Hepatocellular Carcinoma Diagnosed by Peroral Cholangioscopy

DEN Open, Volume 6, Issue 1, April 2026.
Abstract While hepatocellular carcinoma (HCC) often invades the portal or hepatic vein to form tumor thrombus, tumor thrombus in the bile duct is rare. In such cases, differentiation from intrahepatic cholangiocarcinoma is difficult, and the tumor often appears as a smooth, yellowish‐white, polypoid mass within the bile duct lumen.
Keisuke Kinoshita, Mizuki Endo, Tomoko Tokumaru, Tomoko Saito, Takuro Uchida, Masao Iwao, Mie Arakawa, Kazuhisa Okamoto, Masaaki Kodama, Kazunari Murakami   +9 more
wiley   +1 more source

Hemorrhagic Cystitis Following Hematopoietic Stem Cell Transplantation in Children: A Single Pediatric Center Experience

Pediatric Blood &Cancer, Volume 72, Issue 12, December 2025.
ABSTRACT Background Hemorrhagic cystitis (HC) is a frequent and potentially severe complication following hematopoietic stem cell transplantation (HSCT) in children. It significantly affects the quality of life and prolongs hospitalization. Despite its frequency, no standardized management guidelines exist.
Pauline Mazilier, Laurence Dedeken, Eleonore Powis, Pierluigi Calò, Stéphane Luyckx, Laure Kornreich, Safiatou Diallo, Adriano Salaroli, Christine Devalck   +8 more
wiley   +1 more source

SYNERGY IN MIXED RIBAVERIN-INTERFERON AQUEOS SOLUTIONS

Сеченовский вестник, 2017
Spectrophotometric method of ribavirin determination in aqueous solutions was improved. Feasibility of ribavirin determination in the presence of protein was confirmed.
K. Kienskaya, E. Ilyushenko, I. Belova, M. V. Sardushkin, N. Guznova, V. Piskunova, A. Dremuk, R. Ibragimova, A. V. Kukharenko   +8 more
doaj  

Evaluation of the potential of a new ribavirin analog impairing the dissemination of ovarian cancer cells.

PLoS ONE, 2019
Epithelial ovarian cancers are insidious pathologies that give a poor prognosis due to their late discovery and the increasing emergence of chemoresistance. Development of small pharmacological anticancer molecules remains a major challenge.
Anaïs Wambecke, Carine Laurent-Issartel, Johanne Leroy-Dudal, Florence Giffard, Fanny Cosson, Nadège Lubin-Germain, Jacques Uziel, Sabrina Kellouche, Franck Carreiras   +8 more
doaj   +1 more source

Multiple effects of silymarin on the hepatitis C virus lifecycle [PDF]

, 2010
Silymarin, an extract from milk thistle (Silybum marianum), and its purified flavonolignans have been recently shown to inhibit hepatitis C virus (HCV) infection, both in vitro and in vivo.
Bourne, Nigel, Brimacombe, Claire L, Cao, Feng, Graf, Tyler N, Grove, Joe, Kane, Olivia J, Lohmann, Volker, Martinez, Laura E, McKeating, Jane A, Nahmias, Yaakov, Negash, Amina, Oberlies, Nicholas H, Owen, David M, Polyak, Stephen J, Pécheur, Eve-Isabelle, Tavis, John E, Wagoner, Jessica   +16 more
core   +1 more source

Extracellular Vesicle‐Mediated Regulation of H3C14 Contributes to Gemcitabine Resistance in Bladder Cancer

Journal of Extracellular Vesicles, Volume 14, Issue 11, November 2025.
H3C14 modulates gemcitabine metabolism and is selectively excluded via extracellular vesicles (EVs) in gemcitabine (GCB)‐resistant bladder cancer. CD9⁺/CD63⁺/CD81⁺ EVs (Transport‐EVs) transmit resistance, whereas CD147⁺/LAMB1⁺ EVs (Excretion‐EVs) excrete tumour‐suppressive cargos, highlighting the functional divergence of EV subtypes in GCB resistance.
Cheng‐Shuo Huang, Dah‐Shyong Yu, Shih Sheng Jiang, Ying‐Si Wu, Jar‐Yi Ho, Cheng‐Ping Yu   +5 more
wiley   +1 more source

Ribavirin Contributes to Hepatitis C Virus Suppression by Augmenting pDC Activation and Type 1 IFN Production. [PDF]

PLoS ONE, 2015
Ribavirin is used as a component of combination therapies for the treatment of chronic hepatitis C virus (HCV) infection together with pegylated interferon and/or direct-acting antiviral drugs. Its mechanism of action, however, is not clear.
Yang Wang, David R McGivern, Liang Cheng, Guangming Li, Stanley M Lemon, Junqi Niu, Lishan Su, Natalia J Reszka-Blanco   +7 more
doaj   +1 more source