Results 91 to 100 of about 69,829 (275)

Use of Ribavirin for Hepatitis C Treatment in the Modern Direct-acting Antiviral Era

Journal of Clinical and Translational Hepatology, 2018
Ribavirin, once a staple of hepatitis C treatment, has significant drawbacks, including treatment-limiting side effects, the requirement for intensive laboratory monitoring, the need for frequent dose adjustments, and teratogenicity.
P. Mathur, S. Kottilil, E. Wilson
semanticscholar   +1 more source

Therapeutic Effects of Ribavirin Given by the Intraperitoneal or Aerosol Route Against Influenza Virus Infections in Mice [PDF]

, 1976
E. L. Stephen, Joseph W. Dominik, J. B. Moe, J. S. Walker   +3 more
openalex   +1 more source

Targeting EIF4E signaling with ribavirin in infant acute lymphoblastic leukemia

Oncogene, 2018
The poor outcomes in infant acute lymphoblastic leukemia (ALL) necessitate new treatments. Here we discover that EIF4E protein is elevated in most cases of infant ALL and test EIF4E targeting by the repurposed antiviral agent ribavirin, which has ...
K. Urtishak, Li-San Wang, B. Culjkovic-Kraljacic, J. Davenport, Patrizia Porazzi, T. Vincent, D. Teachey, S. Tasian, Jonni S. Moore, A. Seif, Shenghao Jin, J. Barrett, B. Robinson, I. Chen, R. Harvey, M. Carroll, A. Carroll, N. Heerema, M. Devidas, Z. Dreyer, J. Hilden, S. Hunger, C. Willman, K. Borden, C. Felix   +24 more
semanticscholar   +1 more source

EFFECT OF RIBAVIRIN ON VIRAL HEPATITIS IN LABORATORY ANIMALS [PDF]

, 1977
Robert W. Sidwell, John H. Huffman, Nancy Campbell, Lois B. Allen   +3 more
openalex   +1 more source

The Ribavirin Pregnancy Registry: An Interim Analysis of Potential Teratogenicity at the Mid-Point of Enrollment

Drug Safety, 2017
IntroductionSignificant teratogenic effects have been demonstrated in all animal species exposed to ribavirin. Ribavirin is prescribed for chronic hepatitis C and is contraindicated in women who are pregnant and in the male sexual partners of women who ...
S. Sinclair, Judith K Jones, Richard K. Miller, M. Greene, P. Kwo, W. Maddrey   +5 more
semanticscholar   +1 more source

Gilbert’s syndrome and antiviral therapy of hepatitis C

Annals of Hepatology, 2009
Treatment of chronic hepatitis C with type I interferons and ribavirin can be associated with exacerbation of hepatitis and sometimes liver decompensation.
Katja Deterding, Kurt Grüngreiff, Tim O. Lankisch, Andrej Potthoff, Matthias J. Bahr, Michael P. Manns, Heiner Wedemeyer, Christian P. Strassburg   +7 more
doaj   +1 more source

EFFECT OF RIBAVIRIN ON VIRAL TRANSCRIPTION [PDF]

, 1987
Philip Toltzis, Holly Glover, Kevin O‘Connell, Jean L. Patterson   +3 more
openalex   +1 more source

Effect of Ribavirin and immune serum on Junin virus-infected primates [PDF]

, 1986
Mercedes Weissenbacher, María Mercedes Ávila, Miguel A. Calello, M. S. Merani, Joseph B. McCormick, Marı́a Eugenia Rodrı́guez   +5 more
openalex   +1 more source

Modeling Ribavirin‐Induced Anemia in Patients with Chronic Hepatitis C Virus

CPT: Pharmacometrics & Systems Pharmacology, 2016
Ribavirin remains an important component of hepatitis C treatment in certain clinical scenarios, but it causes hemolytic anemia. A quantitative understanding of the ribavirin exposure‐anemia relationship is important in dose individualization ...
LS Wu, LC Jimmerson, CE MacBrayne, JJ Kiser, DZ D'Argenio   +4 more
doaj   +1 more source

Impact of ITPA gene polymorphism for predicting anemia and treatment outcome in HCV infected patients taking Sofosbuvir Ribavirin therapy

BMC Infectious Diseases
Background Globally, 80 million people are suffering from chronic Hepatitis C virus (HCV) infection. Sofosbuvir ribavirin-based anti-HCV therapy is associated with anemia and other adverse effects.
Sameen Amjed, Hafiz Ghulam Murtaza Saleem, Sajjad Ullah, Shahzad Latif, Shabana, Junaid Jafar, Ahmad Bilal Waqar   +6 more
doaj   +1 more source