Results 81 to 90 of about 49,244 (195)

Evaluation of the potential of a new ribavirin analog impairing the dissemination of ovarian cancer cells.

PLoS ONE, 2019
Epithelial ovarian cancers are insidious pathologies that give a poor prognosis due to their late discovery and the increasing emergence of chemoresistance. Development of small pharmacological anticancer molecules remains a major challenge.
Anaïs Wambecke, Carine Laurent-Issartel, Johanne Leroy-Dudal, Florence Giffard, Fanny Cosson, Nadège Lubin-Germain, Jacques Uziel, Sabrina Kellouche, Franck Carreiras   +8 more
doaj   +1 more source

Ribavirin Induces Polyamine Depletion via Nucleotide Depletion to Limit Virus Replication

Cell Reports, 2019
Summary: Common antivirals include nucleoside or nucleotide analogs with base prodrugs. The antiviral ribavirin, a US Food and Drug Administration (FDA)-approved nucleoside antimetabolite, halts guanine production, mutagenizes viral genomes, and ...
Patrick M. Tate, Vincent Mastrodomenico, Bryan C. Mounce   +2 more
doaj   +1 more source

Cross‐Neutralizing and Broadly Neutralizing Human Antibodies Against Nonenveloped Viruses

European Journal of Immunology, Volume 56, Issue 10, October 2026.
In this review article, Marchand et al. compare cross ‐ and broadly ‐neutralizing human antibodies against non ‐ enveloped viruses from several major families, discussing their structural characteristics, neutralization mechanisms and relevance for the development of antiviral vaccines and therapeutics.
Sarah Marchand, Samy Taouli, Dorian McIlroy   +2 more
wiley   +1 more source

Ribavirin Monitoring in Chronic Hepatitis C Therapy: Anaemia versus Efficacy

, 2010
The standard treatment of HCV infection with pegylated interferon-α2a or -α2b and ribavirin is effective in <50% of HCV genotype-1-infected patients. To improve this figure, it might be desirable to obtain optimal plasma concentrations of the drug by
Dominique Capron, Sandrine Castelain, Eric Nguyen-Khac, Catherine François, Gilles Duverlie, Etienne Brochot   +5 more
core   +1 more source

Frequency of Metabolic Syndrome in Patients With Hepatitis C Virus Infection: A Cross‐Sectional Study

Health Science Reports, Volume 9, Issue 10, October 2026.
ABSTRACT Background and Aim Metabolic syndrome significantly increases the risk of cardiovascular disease and type 2 diabetes. Hepatitis C virus (HCV) infection has been associated with an increased risk of metabolic syndrome. This study aims to explore this association to improve management strategies for HCV patients at risk of metabolic syndrome ...
Muhammad Awais, Maryam Ilyas, Muhammad Husnain Ahmad, Muhammad Taha Shaukat, Abdul Waheed, Aniqa Iqbal, Muhammad Umar Nadeem, Nimra Mahmood, Ali Gohar, Hamza Zaheer, Ahmed Zia, Masab Ali   +11 more
wiley   +1 more source

Plasma Exchange for Hantavirus Pulmonary Syndrome: A Mechanistic Case for an Untested Intervention

Journal of Clinical Apheresis, Volume 41, Issue 5, October 2026.
ABSTRACT Hantavirus pulmonary syndrome (HPS) carries a case fatality rate of 35%–40% and has no approved pharmacologic treatment. Its pathophysiology is rooted in the plasma compartment: cytokines, viral antigens, immune complexes, and platelet‐binding glycoproteins circulate as drivers of immunopathologic endothelial injury, noncardiogenic pulmonary ...
Menatalla Nadim, Yasamin Mirzabeigi, Yamac Akgun   +2 more
wiley   +1 more source

The enzymatic synthesis of nucleoside analogues [PDF]

Ribavirin, 1--D-ribofuranosyl-1,2,4-triazole-3-carboxamide, is a broad spectrum antiviral agent active against both DNA and RNA viruses. A range of 1,2,3-triazole, 1,2,4-triazole and benzotriazole analogues of ribavirin was synthesised using a crude ...
O'Connell, Grace Josephine
core  

The impact of ribavirin plasma concentration on the eficacy of the interferon-sparing regimen, sofosbuvir and ribavirin

, 2016
Background: Ribavirin augments sustained virological response when administered with pegylated interferon for the treatment of chronic HCV infection.
Schteinman, Ana, Alavi, M ; https://orcid.org/, Dore, Gregory J ; https://orcid.org/, Williams, Kenneth, Martinello, Marianne ; https://orcid.org/, Martinello, M ; https://orcid.org/, Matthews, Gail V ; https://orcid.org/, Schteinman, A, Day, Richard ; https://orcid.org/, Williams, K, Dore, GJ ; https://orcid.org/, Alavi, Maryam ; https://orcid.org/, Matthews, GV ; https://orcid.org/, Day, R ; https://orcid.org/   +13 more
core   +1 more source

Ribavirin up-Regulates the Activity of Double-Stranded Rna-Activated Protein Kinase and Enhances the Action of Interferon-Alpha against Hepatitis C Virus

, 2008
Background. Ribavirin's mechanism of action in the treatment of chronic hepatitis C remains to be clarified. Double- stranded RNA-activated protein kinase (PKR) plays a role in cell defense against virus infection.
劉韋良;黃麗華;陳惠玲;陳定信;賴明陽, LIU, WEI-LIANG;HWANG, LIH-HWA;CHEN, HUI-LING;CHEN, DING-SHINN;LAI, MING-YANG   +1 more
core  

Hepatitis E virus mutations associated with ribavirin treatment failure result in altered viral fitness and ribavirin sensitivity

, 2016
International audienceBACKGROUND & AIMS: Ribavirin monotherapy is the preferred treatment for chronic hepatitis E, although occasional treatment failure occurs. We present a patient with chronic hepatitis E experiencing ribavirin treatment failure with a
Ramière, Christophe, Trabaud, Mary-Anne, Legras-Lachuer, Catherine, Dallmeier, Kai, de Lamballerie, Xavier, Debing, Yannick, Roche, Magali, Lebossé, Fanny, Lamballerie, Xavier, De, André, Patrice, Scholtès, Caroline, Piorkowski, Géraldine, Lamballerie, Xavier,, Neyts, Johan   +13 more
core   +1 more source