Results 61 to 70 of about 33,368 (159)
MicrobiologyOpen, Volume 15, Issue 3, June 2026.Griffithsin, Brevinin‐2, and CCL20 were identified as potent MERS‐CoV fusion inhibitor candidates targeting the HR2 domain through integrated molecular docking, MD simulations, and MM/PBSA analyses. These peptides demonstrated superior binding stability and favorable safety profiles compared to the standard inhibitor, supporting their potential as ...
Nasser Alotaiq +2 more
wiley +1 more source
Ribavirin exerts differential effects on functions of Cd4+ Th1, Th2, and regulatory T cell clones in hepatitis C. [PDF]
PLoS ONE, 2012 Ribavirin improves outcomes of therapy in chronic hepatitis C but its mode of action has still remained unclear. Since ribavirin has been proposed to modulate the host's T cell responses, we studied its direct effects on CD4(+) T cell clones with diverse
Bettina Langhans +6 more
doaj +1 more source
Antiviral Resistance in Influenza: Clinical and Public Health Implications
Influenza and Other Respiratory Viruses, Volume 20, Issue 6, June 2026.ABSTRACT Timely antiviral treatment and prevention can diminish the morbidity and mortality caused by influenza seasonal, zoonotic, and pandemic infections. However, the emergence of antiviral resistance threatens the utility of available agents and sometimes contributes to poor clinical outcomes.
Jinghao Nicholas Ngiam +2 more
wiley +1 more source
A Framework for Emergency Department–Integrated Hepatitis C Test‐and‐Treat in the United States
Journal of Viral Hepatitis, Volume 33, Issue 6, June 2026.ABSTRACT Despite the availability of curative, direct‐acting antiviral therapy, hepatitis C virus elimination remains incomplete. Losses across the care cascade continue to limit impact, from initial diagnosis to sustained virologic response. Fewer than 1/3 of individuals ultimately achieve cure. These gaps reflect a delivery system that does not align
Saeed S. Graham
wiley +1 more source
Saudi Pharmaceutical JournalBackground: Skin is regarded as an essential first line of defense against harmful pathogens and it hosts an ecosystem of microorganisms that create a widely diverse skin microbiome.
Khulud A. Alsulami +11 more
doaj +1 more source
PLoS ONE, 2019 Epithelial ovarian cancers are insidious pathologies that give a poor prognosis due to their late discovery and the increasing emergence of chemoresistance. Development of small pharmacological anticancer molecules remains a major challenge.
Anaïs Wambecke +8 more
doaj +1 more source
Journal of Viral Hepatitis, Volume 33, Issue 6, June 2026.ABSTRACT Achieving hepatitis C virus (HCV) elimination requires innovative paradigms that overcome barriers to treatment, such as requiring pre‐treatment elastography or phlebotomy‐based fibrosis assessment. To identify patients at low risk of advanced fibrosis or decompensated cirrhosis within our HCV treatment programme, we developed and ...
Hunter Spencer +4 more
wiley +1 more source
Liver International, Volume 46, Issue 6, June 2026.ABSTRACT Background Previous exposure to hepatitis B virus (HBV) may influence the risk of developing hepatocellular carcinoma (HCC) and other liver‐related events (LRE), in particular in patients after HCV cure. Previous studies were not conclusive and there are only few large studies on this topic from Europe. Methods We analysed clinical endpoints (≥
Laura Muana Wilhelm +10 more
wiley +1 more source
ChemMedChem, Volume 21, Issue 10, 27 May 2026.Development of a three‐step synthesis and replacement of the cycloheptyl moiety in cycloheptathiophene‐3‐carboxamide derivatives revealed how thiophene C‐5 substitutions modulate PA–PB1 inhibition, antiviral potency, and water solubility. The phenyl analog 9 delivered sub‐µM potency across multiple IV strains, while the methyl analog 5 achieved the ...
Tommaso Felicetti +8 more
wiley +1 more source