Results 61 to 70 of about 49,244 (195)

Ribavirin inhibits angiogenesis by tetrahydrobiopterin depletion.

, 2007
Ribavirin is a broad-spectrum antiviral drug that is used to treat hepatitis C virus (HCV)-infected patients. The virological response after ribavirin treatment appears to be insufficient to fully explain ribavirin-induced beneficial effects ...
Michaelis, Martin, Cinatl, Jindrich, Schmidt, Helmut, Suhan, Tatyana, Doerr, Hans Wilhelm, Michaelis, U. Ruth, Mohamed, Annisuddin   +6 more
core   +1 more source

Effect of Ribavirin on Hepatitis A Virus Replication In Vitro

Canadian Journal of Infectious Diseases, 1992
The effect of ribavirin on fetal Rhesus monkey kidney cells (FRhK-4) acutely or chronically infected with hepatitis A virus was studied. The effect of ribavirin on hepatitis A virus yield as detected by radioimmunoassay in acutely infected FRhK-4 cells ...
Rabindra K Chaudhary, Anton P Andonov
doaj   +1 more source

Systematic Review and Meta-analysis of Postexposure Prophylaxis for Crimean-Congo Hemorrhagic Fever Virus among Healthcare Workers

Emerging Infectious Diseases, 2018
We performed a systematic review and meta-analysis on the effectiveness of ribavirin use for the prevention of infection and death of healthcare workers exposed to patients with Crimean-Congo hemorrhagic fever virus (CCHFV) infection. Splashes with blood
Önder Ergönül, Şiran Keske, Melis Gökçe Çeldir, İlayda Arjen Kara, Natalia Pshenichnaya, Gulzhan Abuova, Lucille Blumberg, Mehmet Gönen   +7 more
doaj   +1 more source

Beat‐to‐beat variability of ventricular repolarization reveals sex‐specific instability and proarrhythmic risk

The Journal of Physiology, EarlyView.
Abstract figure legend A mechanistic framework linking sex‐dependent dynamical instability to proarrhythmic risk. Sex‐specific human ventricular models show that upstream modulators, including biological sex, hormones, drugs and heart disease, promote steeper APD restitution in female than male and enhance dynamical instability.
Daisuke Sato, Lorenzo Santini, Raffaele Coppini, Eleonora Grandi   +3 more
wiley   +1 more source

Brain distribution of ribavirin after intranasal administration

, 2011
Ribavirin has proved to be effective in vitro against several RNA viruses responsible for encephalitis in humans and animals. However, the in vivo efficacy towards the cerebral viral load seems to be limited by the blood-brain barrier.
GIULIANI, ALESSANDRO, COLOMBO, Gaia, Giampiero Pagliuca, Fabio Sonvico, Gaia Colombo, Calzà, L, Galligioni, V, PAGLIUCA, GIAMPIERO, Pagliuca, G, Alessandro Giuliani, G. PAGLIUCA, Colombo, G, Lorenzini, L, A. SCAGLIARINI, Pagliuca G., SONVICO, Fabio, E. ZIRONI, Colombo G., Elisa Zironi, F. SONVICO, A. GIULIANI, GALLIGIONI, VIOLA, Balducci A.G., Galligioni V., Giuliani A., Viola Galligioni, ZIRONI, ELISA, L. LORENZINI, A. G. BALDUCCI, Balducci, AG, CALZA', LAURA, Anna Giulia Balducci, Sonvico, F, BALDUCCI, Anna Giulia, Scagliarini, A, Laura Calzà, Zironi E., Alessandra Scagliarini, Giuliani, A, Calzà L., L. CALZA', LORENZINI, LUCA, Zironi, E, Luca Lorenzini, Scagliarini A., V. GALLIGIONI, Sonvico F., SCAGLIARINI, ALESSANDRA, Lorenzini L.   +48 more
core   +1 more source

Ribavirin for Crimean-Congo hemorrhagic fever: systematic review and meta-analysis

BMC Infectious Diseases, 2010
Background Crimean-Congo hemorrhagic fever epidemics often occur in areas where health services are limited, and result in high case fatality rates. Besides intensive care, ribavirin is often recommended.
G Gail, Thomas Sherine, Soares-Weiser Karla, Garner Paul   +3 more
doaj   +1 more source

Incidence, risk factors and impact on virological response of anemia in chronic genotype 2 hepatitis C receiving sofosbuvir plus ribavirin

Journal of the Formosan Medical Association, 2020
Background/Purpose: The major dose-limiting toxicity of ribavirin is hemolytic anemia. We investigated the incidence, risk factors and impact on virological response of anemia in chronic hepatitis C genotype 2 patients receiving sofosbuvir plus ribavirin
Chi-Ching Chen, Shui-Yi Tung, Kuo-Liang Wei, Chien-Heng Shen, Te-Sheng Chang, Wei-Ming Chen, Huang-Wei Xu, Chih-Wei Yen, Yi-Hsing Chen, Sheng-Nan Lu, Chao-Hung Hung   +10 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, Volume 20, Issue 11, Page 2936-2954, November 2026.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Randomized Trial Evaluating the Impact of Ribavirin Mono-Therapy and Double Dosing on Viral Kinetics, Ribavirin Pharmacokinetics and Anemia in Hepatitis C Virus Genotype 1 Infection. [PDF]

PLoS ONE, 2016
In this pilot study (RibaC), 58 hepatitis C virus (HCV) genotype 1 infected treatment-naïve patients were randomized to (i) 2 weeks ribavirin double dosing concomitant with pegylated interferon-α (pegIFN-α), (ii) 4 weeks ribavirin mono-therapy prior to ...
Jesper Waldenström, Johan Westin, Kristina Nyström, Peer Christensen, Olav Dalgard, Martti Färkkilä, Karin Lindahl, Staffan Nilsson, Gunnar Norkrans, Henrik Krarup, Hans Norrgren, Mads Rauning Buhl, Stephan Stenmark, Martin Lagging   +13 more
doaj   +1 more source

Meroterpenoids Produced by Fungi: Occurrence, Structural Diversity, and Biological Activity (An Update: February 2020 to December 2025)

Chemistry &Biodiversity, Volume 23, Issue 11, November 2026.
This review firstly summarizes the update of meroterpenoids from February 2020 to December 2025 by applying a new classification method based on twelve key non‐terpene precursors. ABSTRACT Meroterpenoids are a class of hybrid natural products, biosynthesized from terpenoid fragments and non‐terpenoid precursors, exhibiting a wide range of biological ...
Yuqian Tang, Jinqin Wei, Zhao Jiang, Yingming Luo, Yan Zhou, Jiafan Yang, Hui Cui   +6 more
wiley   +1 more source