Results 21 to 30 of about 61,737 (200)

Extinction of hepatitis C virus by ribavirin in hepatoma cells involves lethal mutagenesis. [PDF]

PLoS ONE, 2013
Lethal mutagenesis, or virus extinction produced by enhanced mutation rates, is under investigation as an antiviral strategy that aims at counteracting the adaptive capacity of viral quasispecies, and avoiding selection of antiviral-escape mutants.
Ana M Ortega-Prieto, Julie Sheldon, Ana Grande-Pérez, Héctor Tejero, Josep Gregori, Josep Quer, Juan I Esteban, Esteban Domingo, Celia Perales   +8 more
doaj   +1 more source

Evaluation of the efficacy of sofosbuvir plus daclatasvir in combination with ribavirin for hospitalized COVID-19 patients with moderate disease compared with standard care: a single-centre, randomized controlled trial

Journal of Antimicrobial Chemotherapy, 2020
Background New therapeutic options are urgently needed to tackle the novel coronavirus disease 2019 (COVID-19). Repurposing existing pharmaceuticals provides an immediate treatment opportunity.
Hamideh Abbaspour Kasgari, S. Moradi, A. Shabani, F. Babamahmoodi, Ali Reza Davoudi Badabi, L. Davoudi, A. Alikhani, Akbar Hedayatizadeh Omran, M. Saeedi, S. Merat, H. Wentzel, A. Garratt, J. Levi, Bryony Simmons, A. Hill, Hafez Tirgar Fakheri   +15 more
semanticscholar   +1 more source

Lack of Evidence for Ribavirin Treatment of Lassa Fever in Systematic Review of Published and Unpublished Studies

Emerging Infectious Diseases, 2022
Ribavirin has been used widely to treat Lassa fever in West Africa since the 1980s. However, few studies have systematically appraised the evidence for its use.
Hung-Yuan Cheng, Clare E. French, Alex P. Salam, Sarah Dawson, Alexandra McAleenan, Luke A. McGuinness, Jelena Savović, Peter W. Horby, Jonathan A.C. Sterne   +8 more
doaj   +1 more source

Effects of Host and virus related factors on Interferon-α+ribavirin and Pegylated-interferon+ribavirin treatment outcomes in Chronic Hepatitis C patients

Virology Journal, 2011
Background Current standard therapy commonly followed for chronic Hepatitis C Virus (HCV) in Pakistan is interferon alpha plus ribavirin combination therapy (IFN α/ribavirin) and pegylated interferon plus ribavirin (PegIFN/ribavirin).
Saleem Sana, Liaqat Ali, Rehman Irshad-ur, Afzal Samia, Butt Sadia, Hussain Abrar, Zafar Shamail, Idrees Muhammad, Akram Madiha, Ali Muhammad, Butt Azeem   +10 more
doaj   +1 more source

Ledipasvir/sofosbuvir and ribavirin for the treatment of ribavirin-refractory persistent hepatitis E virus infection

IDCases, 2023
Persistent Hepatitis E Virus infection (HEV) is a rare but increasingly recognised condition in immunocompromised individuals. Untreated, this infection can rapidly progress to cirrhosis.
Jennifer Gallacher, Yusri Taha, Ana da Silva Filipe, Samreen Ijaz, Stuart McPherson   +4 more
doaj   +1 more source

Ribavirin shows antiviral activity against SARS-CoV-2 and downregulates the activity of TMPRSS2 and the expression of ACE2 In Vitro

bioRxiv, 2020
Ribavirin is a guanosine analog and has a broad-spectrum antiviral activity against RNA viruses. Based on this, we aimed to show the anti-SARS-CoV-2 activity of this drug molecule via in vitro, in silico and molecular techniques.
M. A. Unal, C. V. Bitirim, Gokce Yagmur Summak, Sidar Bereketoğlu, Inci Cevher Zeytin, Omur Bul, C. Gurcan, Dunya Aydos, E. Goksoy, Ebru Kocakaya, Zeynep Eran, Merve Murat, Nil Demir, Julia Somers, E. Demir, H. Nazır, S. Ozkan, A. Ozkul, A. Azap, A. Yilmazer, K. Akcali   +20 more
semanticscholar   +1 more source

Enhancement of Crystallization Process of the Organic Pharmaceutical Molecules through High Pressure

Crystals, 2022
The enhancement of the crystallization process through high pressures was studied by using ribavirin (RVB) as a model compound. The effects of high pressure on crystallization thermodynamics, nucleation kinetics, and process yield were evaluated and ...
Yaoguang Feng, Hongxun Hao, Yiqing Chen, Na Wang, Ting Wang, Xin Huang   +5 more
doaj   +1 more source

Structural and molecular basis of mismatch correction and ribavirin excision from coronavirus RNA

Proceedings of the National Academy of Sciences of the United States of America, 2017
Significance Emerging coronaviruses (CoVs; severe acute respiratory syndrome-CoV and Middle East respiratory syndrome-CoV) pose serious health threats globally, with no specific antiviral treatments available.
F. Ferron, Lorenzo Subissi, Ana Theresa Silveira De Morais, N. Le, M. Sévajol, L. Gluais, E. Decroly, C. Vonrhein, G. Bricogne, B. Canard, I. Imbert   +10 more
semanticscholar   +1 more source

Adverse Skin Reactions due to Ribavirin in Hepatitis C Combination Therapy with Pegylated Interferon-α2a

Case Reports in Dermatology, 2013
The introduction of ribavirin to hepatitis C combination therapy with pegylated interferon (PEG-IFN)-α2a has improved sustained responses, but it has been accompanied by an increased incidence of cutaneous side effects. Most cases of drug eruption caused
Masahisa Shindo, Isamu Terai
doaj   +1 more source

Evaluation of Ribavirin–Poloxamer Microparticles for Improved Intranasal Absorption

Pharmaceutics, 2021
Ribavirin is a water-soluble antiviral compound which, owing to its inability to cross the blood–brain barrier, has limited effectiveness in treating viruses affecting the central nervous system.
Dipy M. Vasa, Zainab Bakri, Maureen D. Donovan, Lauren A. O’Donnell, Peter L. D. Wildfong   +4 more
doaj   +1 more source