Response to combination therapy with interferon alfa-2a and ribavirin in chronic hepatitis C according to a TNF-alpha promoter polymorphism [PDF]
, 2003 Background. Tumor necrosis factor-alpha (TNF-alpha) is involved in the pathogenesis of chronic active hepatitis C. Polymorphisms in the promoter region of the TNF-alpha gene can alter the TNF-alpha expression and modify the host immune response.
Konig, A. +8 more
core +1 more source
Ribavirin enhances IFN-α signalling and MxA expression: a novel immune modulation mechanism during treatment of HCV. [PDF]
PLoS ONE, 2011 The nucleoside analogue Ribavirin significantly increases patient response to IFN-α treatment of HCV, by directly inhibiting viral replication. Recent studies indicate that Ribavirin also regulates immunity and we propose that Ribavirin enhances specific
Nigel J Stevenson +5 more
doaj +1 more source
Adding low-dose antidepressants to interferon alpha treatment for chronic hepatitis C improved psychiatric tolerability in a patient with schizoaffective psychosis [PDF]
, 2000 Treatment of chronic hepatitis C with interferon alpha (IFN-alpha) is relatively contraindicated in patients with psychiatric disorders because of possible severe psychiatric side effects.
Amann, B. +5 more
core +1 more source
Ribavirin Enhances Interferon Signaling Via Stimulation of Mtor and P53 Activities
, 2010 Cellular mechanisms involving the enhancement of interferon( IFN) signaling by ribavirin remain poorly understood. Here, we identified a novel role of ribavirin in the communication between p53 and the mammalian target of rapamycin ( mTOR) signaling ...
SU, WEN-CHENG;LIU, WEI-LIANG;CHENG, CHING-WEI;WU, CHAO-LIANG;SHIAU, AI-LI;LAI, MING-YANG +1 more
core +2 more sources
Ribavirin inhibits the replication of infectious bursal disease virus predominantly through depletion of cellular guanosine pool [PDF]
, 2023 IntroductionThe antiviral activity of different mutagens against single-stranded RNA viruses is well documented; however, their activity on the replication of double-stranded RNA viruses remains unexplored.
Irfan Gul +10 more
core +1 more source
Emerging Infectious Diseases, 2022 Ribavirin has been used widely to treat Lassa fever in West Africa since the 1980s. However, few studies have systematically appraised the evidence for its use.
Hung-Yuan Cheng +8 more
doaj +1 more source
Ribavirin dose management in HCV patients receiving ombitasvir/paritaprevir/ritonavir and dasabuvir with ribavirin [PDF]
, 2018 Background & Aims: Some individuals with hepatitis C virus infection treated with direct-acting antivirals require ribavirin to maximize sustained virological response rates.
Ferenci, Peter +20 more
core +1 more source
Impact of Genetic Variants in Inosine Triphosphate Pyrophosphatase and Interferon-λ4 on Natural History, Treatment Response and Ribavirin Pharmacology in Hepatitis C Virus Infection [PDF]
, 2020 Hepatitis C virus (HCV) impacts on global health with around 70 million chronically infected worldwide. The infection increases the risk of cirrhosis and primary liver cancer.
Waldenström, Jesper
core +1 more source
Enhancement of Crystallization Process of the Organic Pharmaceutical Molecules through High Pressure
Crystals, 2022 The enhancement of the crystallization process through high pressures was studied by using ribavirin (RVB) as a model compound. The effects of high pressure on crystallization thermodynamics, nucleation kinetics, and process yield were evaluated and ...
Yaoguang Feng +5 more
doaj +1 more source
Evaluation of Ribavirin–Poloxamer Microparticles for Improved Intranasal Absorption
Pharmaceutics, 2021 Ribavirin is a water-soluble antiviral compound which, owing to its inability to cross the blood–brain barrier, has limited effectiveness in treating viruses affecting the central nervous system.
Dipy M. Vasa +4 more
doaj +1 more source