Results 31 to 40 of about 47,954 (202)

Ribavirin plasma concentration measurements in patients with hepatitis C: early ribavirin concentrations predict steady-state concentrations [PDF]

, 2011
BACKGROUND: Ribavirin is an essential component in the treatment of chronic hepatitis C (HCV) infection. Although ribavirin dose is weight-based, data in the literature suggest large between-patient variability in plasma ribavirin concentrations.
Drenth, J.P.H., Koopmans †, P.P., Hanneke W H A Huntjens-Fleuren, Ton S M Dofferhoff, Huntjens-Fleuren, H.W., Joost P H Drenth, Burger, D.M., David M Burger, Slavenburg, S., Clemens Richter, Corrien P W G M Verwey-Van Wissen, Verwey-van Wissen, C.P.W.G.M., Serena Slavenburg, Richter, C., Dofferhoff, T.S., Peter P Koopmans   +15 more
core   +1 more source

Low-Dose Ribavirin Treatments Attenuate Neuroinflammatory Activation of BV-2 Cells by Interfering with Inducible Nitric Oxide Synthase

Analytical Cellular Pathology, 2015
Microglia play a key role in defending central nervous system from various internal and external threats. However, their excessive and/or chronic activation is associated with deleterious effects in a variety of neurodegenerative diseases. Previously, we
Iva Bozic, Danijela Savic, Marija Jovanovic, Ivana Bjelobaba, Danijela Laketa, Nadezda Nedeljkovic, Mirjana Stojiljkovic, Sanja Pekovic, Irena Lavrnja   +8 more
doaj   +1 more source

Influence of Ribavirin Serum Levels on Outcome of Antiviral Treatment and Anemia in Hepatitis C Virus Infection.

PLoS ONE, 2016
BackgroundRibavirin blood levels vary considerably between patients with standard weight-based dosing. Their impact on sustained virological response (SVR) with pegylated interferon and ribavirin is controversial, but has mostly been studied before the ...
Thomas Kuntzen, Sereina Kuhn, Daniela Kuntzen, Burkhardt Seifert, Beat Müllhaupt, Andreas Geier   +5 more
doaj   +1 more source

Association of IFNL3 rs12979860 and rs8099917 with biochemical predictors of interferon responsiveness in chronic hepatitis C virus infection [PDF]

, 2013
Background & Aims: Genetic variations near the interferon lambda 3 gene (IFNL3, IL28B) are the most powerful predictors for sustained virologic response (SVR) in patients with chronic hepatitis C virus (HCV) infection, compared to other biochemical or ...
Simone Susser (48294), Annika Brodzinski, Thomas Berg (186372), Migaud, Pascal, Jacob George (205614), Brodzinski, Annika, Tobias Müller, Susser, Simone, Stephan Böhm (334611), Sarrazin, Christoph, Christoph Sarrazin (48298), Pascal Migaud, Schott, Eckart, Bömmel, Florian van, Heiko Witt, Florian van Bömmel, Janett Fischer, Christoph Sarrazin, Stewart, Graeme, Graeme Stewart, Witt, Heiko, Thomas Berg, Simone Susser, Balazs Fülöp, Fülöp, Balazs, Stephan Böhm, Annika Brodzinski (477753), Balazs Fülöp (477754), Müller, Tobias, Fischer, Janett, Böhm, Stephan, Berg, Thomas, Tobias Müller (163591), Janett Fischer (477751), Eckart Schott (320945), Graeme Stewart (208243), Jacob George, Heiko Witt (161481), Pascal Migaud (477752), George, Jacob, Eckart Schott, Florian van Bömmel (477755)   +41 more
core   +1 more source

RINDERPEST VIRUS INHIBITION IN VITRO BY RABAVIRIN [PDF]

Veterinary Medical Journal - Giza, 1995
The effect of the broad-spectrum antivirus ribavirin has been tested against the replication of rinderpest virus (RPV) in bovine kidney cells (BK) as a primary culture and Vero cell line culture. Ribavirin showed no effect on growth and viability of both
HUSSEIN M, KHODEIR H, MOUAZ A, RASHWAN T, SAMIA A, SEHAM S   +5 more
doaj   +1 more source

Ribavirin Enhances Interferon Signaling Via Stimulation of Mtor and P53 Activities

, 2010
Cellular mechanisms involving the enhancement of interferon( IFN) signaling by ribavirin remain poorly understood. Here, we identified a novel role of ribavirin in the communication between p53 and the mammalian target of rapamycin ( mTOR) signaling ...
SU, WEN-CHENG;LIU, WEI-LIANG;CHENG, CHING-WEI;WU, CHAO-LIANG;SHIAU, AI-LI;LAI, MING-YANG, 蘇文正;劉韋良;程靜暐;吳昭良;蕭璦莉;賴明陽   +1 more
core   +1 more source

Influence of chemotherapy on development and production of virus free in vitro strawberry plants

Horticultural Science, 2019
The objective of the study was to determine effects of ribavirin on development and health status of in vitro grown strawberry cultivars 'Honeoye' and 'Elkat' infected with viruses Strawberry mild yellow-edge virus (SMYEV), Tomato ringspot virus (ToRSV ...
Jiří Sedlák, František Paprštein, Jana Suchá   +2 more
doaj   +1 more source

Renal Clearable Luminogenic Reporter for Ultrasensitive Influenza Virus Imaging and Efficient Antiviral Therapies Monitoring in Living Mice

Advanced Science, EarlyView.
A viral luminogenic reporter with chemiluminescence/fluorescence dual‐response and efficient renal clearance was developed for non‐invasive imaging and urinalysis of H1N1 virus protease, allowing for remote detection of H1N1 virus infections and monitoring of antiviral therapeutic efficacy in living mice.
Bankang Ruan, Chudan Liang, Meilin Hu, Weiping Xu, Jingjing Che, Jun Qian, Bingcai Jiang, Linna Liu, Xiancai Ma, Jiaguo Huang   +9 more
wiley   +1 more source

Ribavirin dose management in HCV patients receiving ombitasvir/paritaprevir/ritonavir and dasabuvir with ribavirin [PDF]

, 2018
Background & Aims: Some individuals with hepatitis C virus infection treated with direct-acting antivirals require ribavirin to maximize sustained virological response rates.
Ferenci, Peter, Tatsch, Fernando, Ziad Younes, Younes, Z., Younes, Ziad, Lois Larsen, Peter Ferenci, Bernstein, David E, Fernando Tatsch, Feld, Jordan J, Tatsch, F., Van Vlierberghe, Hans, Larsen, Lois, Jordan J. Feld, Ferenci, P., Feld, J. J., Bernstein, D. E., David E. Bernstein, Hans Van Vlierberghe, Van Vlierberghe, H., Larsen, L.   +20 more
core   +1 more source

Dispensing of actionable pharmacogenetic drugs among adults receiving cardiovascular disease medications in the Northern Netherlands: A serial cross‐sectional study

Clinical Pharmacology &Therapeutics, EarlyView.
The extent of pharmacogenetic (PGx) drug dispensing among Dutch adults receiving medications for cardiovascular disease (CVD) is unknown. Using the University of Groningen IADB.nl pharmacy database, we performed a serial cross‐sectional study (2019–2023) to estimate the annual prevalence of PGx drug dispensing and annual rates of initiation.
Zhuolin Zhang, Guiling Zhou, Jens H. J. Bos, Eelko Hak, Talitha Feenstra, Frank Klont   +5 more
wiley   +1 more source