Results 21 to 30 of about 33,368 (159)

Ribavirin enhances IFN-α signalling and MxA expression: a novel immune modulation mechanism during treatment of HCV. [PDF]

PLoS ONE, 2011
The nucleoside analogue Ribavirin significantly increases patient response to IFN-α treatment of HCV, by directly inhibiting viral replication. Recent studies indicate that Ribavirin also regulates immunity and we propose that Ribavirin enhances specific
Nigel J Stevenson, Alison G Murphy, Nollaig M Bourke, Catherine A Keogh, John E Hegarty, Cliona O'Farrelly   +5 more
doaj   +1 more source

Extinction of hepatitis C virus by ribavirin in hepatoma cells involves lethal mutagenesis. [PDF]

PLoS ONE, 2013
Lethal mutagenesis, or virus extinction produced by enhanced mutation rates, is under investigation as an antiviral strategy that aims at counteracting the adaptive capacity of viral quasispecies, and avoiding selection of antiviral-escape mutants.
Ana M Ortega-Prieto, Julie Sheldon, Ana Grande-Pérez, Héctor Tejero, Josep Gregori, Josep Quer, Juan I Esteban, Esteban Domingo, Celia Perales   +8 more
doaj   +1 more source

Lack of Evidence for Ribavirin Treatment of Lassa Fever in Systematic Review of Published and Unpublished Studies

Emerging Infectious Diseases, 2022
Ribavirin has been used widely to treat Lassa fever in West Africa since the 1980s. However, few studies have systematically appraised the evidence for its use.
Hung-Yuan Cheng, Clare E. French, Alex P. Salam, Sarah Dawson, Alexandra McAleenan, Luke A. McGuinness, Jelena Savović, Peter W. Horby, Jonathan A.C. Sterne   +8 more
doaj   +1 more source

Effects of Host and virus related factors on Interferon-α+ribavirin and Pegylated-interferon+ribavirin treatment outcomes in Chronic Hepatitis C patients

Virology Journal, 2011
Background Current standard therapy commonly followed for chronic Hepatitis C Virus (HCV) in Pakistan is interferon alpha plus ribavirin combination therapy (IFN α/ribavirin) and pegylated interferon plus ribavirin (PegIFN/ribavirin).
Saleem Sana, Liaqat Ali, Rehman Irshad-ur, Afzal Samia, Butt Sadia, Hussain Abrar, Zafar Shamail, Idrees Muhammad, Akram Madiha, Ali Muhammad, Butt Azeem   +10 more
doaj   +1 more source

Ledipasvir/sofosbuvir and ribavirin for the treatment of ribavirin-refractory persistent hepatitis E virus infection

IDCases, 2023
Persistent Hepatitis E Virus infection (HEV) is a rare but increasingly recognised condition in immunocompromised individuals. Untreated, this infection can rapidly progress to cirrhosis.
Jennifer Gallacher, Yusri Taha, Ana da Silva Filipe, Samreen Ijaz, Stuart McPherson   +4 more
doaj   +1 more source

Enhancement of Crystallization Process of the Organic Pharmaceutical Molecules through High Pressure

Crystals, 2022
The enhancement of the crystallization process through high pressures was studied by using ribavirin (RVB) as a model compound. The effects of high pressure on crystallization thermodynamics, nucleation kinetics, and process yield were evaluated and ...
Yaoguang Feng, Hongxun Hao, Yiqing Chen, Na Wang, Ting Wang, Xin Huang   +5 more
doaj   +1 more source

Adverse Skin Reactions due to Ribavirin in Hepatitis C Combination Therapy with Pegylated Interferon-α2a

Case Reports in Dermatology, 2013
The introduction of ribavirin to hepatitis C combination therapy with pegylated interferon (PEG-IFN)-α2a has improved sustained responses, but it has been accompanied by an increased incidence of cutaneous side effects. Most cases of drug eruption caused
Masahisa Shindo, Isamu Terai
doaj   +1 more source

Evaluation of Ribavirin–Poloxamer Microparticles for Improved Intranasal Absorption

Pharmaceutics, 2021
Ribavirin is a water-soluble antiviral compound which, owing to its inability to cross the blood–brain barrier, has limited effectiveness in treating viruses affecting the central nervous system.
Dipy M. Vasa, Zainab Bakri, Maureen D. Donovan, Lauren A. O’Donnell, Peter L. D. Wildfong   +4 more
doaj   +1 more source

Influence of Ribavirin Serum Levels on Outcome of Antiviral Treatment and Anemia in Hepatitis C Virus Infection.

PLoS ONE, 2016
BackgroundRibavirin blood levels vary considerably between patients with standard weight-based dosing. Their impact on sustained virological response (SVR) with pegylated interferon and ribavirin is controversial, but has mostly been studied before the ...
Thomas Kuntzen, Sereina Kuhn, Daniela Kuntzen, Burkhardt Seifert, Beat Müllhaupt, Andreas Geier   +5 more
doaj   +1 more source

Low-Dose Ribavirin Treatments Attenuate Neuroinflammatory Activation of BV-2 Cells by Interfering with Inducible Nitric Oxide Synthase

Analytical Cellular Pathology, 2015
Microglia play a key role in defending central nervous system from various internal and external threats. However, their excessive and/or chronic activation is associated with deleterious effects in a variety of neurodegenerative diseases. Previously, we
Iva Bozic, Danijela Savic, Marija Jovanovic, Ivana Bjelobaba, Danijela Laketa, Nadezda Nedeljkovic, Mirjana Stojiljkovic, Sanja Pekovic, Irena Lavrnja   +8 more
doaj   +1 more source