Results 71 to 80 of about 116,832 (281)

Don't Fall for Tuning Parameters: Tuning-Free Variable Selection in High Dimensions With the TREX

, 2015
Lasso is a seminal contribution to high-dimensional statistics, but it hinges on a tuning parameter that is difficult to calibrate in practice. A partial remedy for this problem is Square-Root Lasso, because it inherently calibrates to the noise variance.
Lederer, Johannes, Müller, Christian
core   +1 more source

Dual‐Responsive Dynamic Covalent Bond‐Based Assembly of Lipid‐Nanozyme Systems via Multi‐Target Synergy and Efficient Target Enrichment for Ischemic Stroke Therapy

Advanced Science, EarlyView.
This system adopts a biomimetic phospholipid structure, covalently binding iNOS inhibitors, neuroprotective agent PCA and vitamin E derivatives through pH/ROS dual‐responsive bonds, and assembles them with Prussian blue nanozyme to form PBB@AHA. It can efficiently penetrate the blood‐brain barrier and simultaneously release multiple active components ...
Mengcheng Guo, Qingran Guan, Guanyu Qiao, Lixue Zhang, Man Liu, Zhen Li, Qingbiao Yang, Meili Shen, Linlin Liu, Yapeng Li   +9 more
wiley   +1 more source

The biosynthesis of the flavin moiety of dihydroorotic dehydrogenase of zymobacterium oroticum [PDF]

, 1963
Thesis (M.A.)--Boston ...
Chen, John Heng
core  

Design of Single‐Atom Nanozymes for Precision Treatment of Erectile Dysfunction with Integrated Single‐Cell RNA Sequencing and Machine Learning

Advanced Science, EarlyView.
It is innovatively utilized single‐cell RNA sequencing to explore the underlying causes of diabetes mellitus‐induced erectile dysfunction, followed by machine learning‐driven design of a single‐atom nanozyme (Fe‐DMOF) for precision treatment of erectile dysfunction.
Xiang Zhou, Xi Zhang, Sihan Chen, Mengchi Yu, Yilan Hu, Chi Gan, Xianghu Meng, Long Li, Ninghong Song   +8 more
wiley   +1 more source

Milk [PDF]

, 1963
PDF pages ...
Cole, Darrel, Gruner, Pauline, Koval, Frank, Netz, Irene, Simonds, Lois, Zehr, Donald   +5 more
core  

Riboflavin synthase of Protein dynamics revealed by F NMR protein perturbation experiments [PDF]

, 2003
Background Riboflavin synthase catalyzes the transformation of 6,7-dimethyl-8-ribityllumazine into riboflavin in the last step of the riboflavin biosynthetic pathway. Gram-negative bacteria and certain yeasts are unable to incorporate riboflavin from the
Adelbert Bacher, Ann-Kathrin Schott, Boris Illarionov, Gerald Richter, Kristina Kemter, Mark Cushman, Markus Fischer, Richard Feicht, Robert Huber, Stefan Gerhardt, Stefan Steinbacher, Wolfgang Eisenreich   +11 more
core   +3 more sources

Plant‐Derived Melatonin Inhibits Bacterial Virulence via CpxA/R Two‐Component System

Advanced Science, EarlyView.
Plant‐derived melatonin is sensed by CpxAE48/T51, which inhibits the phosphorylation cascade transmission from CpxAH240 to CpxRD52, resulting in the inhibition of DNA‐binding capacity of CpxR and subsequent T3SS genes expression in Pst DC3000. ABSTRACT In defending against pathogens, plants deploy diverse secondary metabolites and signaling molecules ...
Jin‐Wei Wei, Wei Liu, Bili Cao, Dan Zhao, Chengqiang Wang, Xin Hou, Tangyuan Ning, Biao Gong   +7 more
wiley   +1 more source

Effect of a mixture of caffeine and nicotinamide on the solubility of vitamin (B2) in aqueous solution [PDF]

, 2006
The effect of caffeine (CAF) and nicotinamide (NMD) on the solubility of a vitamin B2 derivative (FMN) has been evaluated for mixtures containing either a single hydrotrope (CAF or NMD) or the two hydrotropes simultaneously.
A.A. Hernandez Santiago, Coffman, Coffman, D.B. Davies, Datta, Davies, Evstigneev, Evstigneev, Fawzi, Hussain, Jain, Khalil, Larsen, Lim, M.P. Evstigneev, Rasool, Redenti, Ribeiro, V.P. Evstigneev, Veselkov, Veselkov, Veselkov, Veselkov   +22 more
core   +1 more source

Light‐Switched Mesenchymal Stem Cells for In Situ Exosome Amplification in Craniofacial Bone Defect Reconstruction

Advanced Science, EarlyView.
Light‐switchable MSCs (MSC‐UCNPs) were constructed by intracellular incorporation of UCNPs. Upon 980 nm irradiation, UCNPs emitted localized ultraviolet light (365 nm), activating the ROS/HEXB/LAMP1 signaling pathway to suppress lysosome–multivesicular body fusion and thereby enhance exosome biogenesis. Embedded within an injectable hydrogel, MSC‐UCNPs
Tingting Wu, Yajing Liu, Shuman Wang, Xiaoming Bai, Luyun Zhang, Yuwei Liu, Zhiwen Fu, Chen Shi   +7 more
wiley   +1 more source

Statistical optimization and random mutagenesis for improved riboflavin production from Lactiplantibacillus pentosus SV13 isolated from dosa batter

Discover Applied Sciences
Aim The study aims to identify and develop an efficient bacterial strain for the production of riboflavin. The developed strain could be a starter culture in the food and pharmaceutical industries.
R. Srivatsan, M. Hemalatha, Sanjeev K. Ganesh, V. Mohanasrinivasan, C. Subathra Devi   +4 more
doaj   +1 more source