Results 11 to 20 of about 465,236 (150)
Ultra-high resolution X-ray structure of orthorhombic bovine pancreatic Ribonuclease A at 100K
BMC Chemistry, 2023 The crystal structure of orthorhombic Bovine Pancreatic Ribonuclease A has been determined to 0.85 Å resolution using low temperature, 100 K, synchrotron X-ray data collected at 16000 keV (λ = 0.77 Å). This is the first ultra-high-resolution structure of
David R. Lisgarten +9 more
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Intramolecular interactions in pancreatic ribonucleases [PDF]
Protein Science, 1992 AbstractA detailed analysis of the composition and properties of hydrophobic nuclei and microclusters in pancreatic ribonuclease A (RNase A) has been carried out. Distance calculations for all noncovalently bonded atoms revealed that the average number of nonpolar contacts between a side chain of an amino acid and its neighbors is substantially larger ...
, Kolbanovskaya EYu +3 more
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A novel ligand-receptor relationship between families of ribonucleases and receptor tyrosine kinases
Journal of Biomedical Science, 2018 Pancreatic ribonuclease is known to participate in host defense system against pathogens, such as parasites, bacteria, and virus, which results in innate immune response. Nevertheless, its potential impact to host cells remains unclear.
Ying-Nai Wang +2 more
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Cancer Cell, 2018 SUMMARY Pancreatic ribonuclease (RNase) is a secreted enzyme critical for host defense. We discover an intrinsic RNase function, serving as a ligand for epidermal growth factor receptor (EGFR), a member of receptor tyrosine kinase (RTK), in pancreatic ...
Ying-Nai Wang +28 more
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Study Levels of Some Biochemical Parameters in Serum of Pancreatic Cancer Patients
Tikrit Journal of Pure Science, 2018 This study included an estimation for the levels of some biochemical parameters in the serum of those pancreatic cancer patients, by collecting (40) blood samples from patients their ages ranged (30-70) years compared with (55) blood samples of healthy ...
Layla A. Mustafa, Zena A. Mohammad
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OncoTarget, 2016 Ribonucleases represent a new class of antitumor RNA-damaging drugs. However, many wild-type members of the vertebrate secreted ribonuclease family are not cytotoxic because they are not able to evade the cytosolic ribonuclease inhibitor.
Anna Vert +4 more
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Scientific Reports, 2014 Alterations of carbohydrate structures in cancer cells are the most promising targets for developing clinical diagnostic reagents. Pancreatic cancer is one of the most difficult cancers to diagnose because it lacks definitive symptoms.
D. Nakata
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Functional role of glutamine 28 and arginine 39 in double stranded RNA cleavage by human pancreatic ribonuclease. [PDF]
PLoS ONE, 2011 Human pancreatic ribonuclease (HPR), a member of RNase A superfamily, has a high activity on double stranded (ds) RNA. By virtue of this activity HPR appears to be involved in the host-defense against pathogenic viruses.
Md Tabish Rehman +4 more
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Molecules, 2021 Although single targeted anti-cancer drugs are envisaged as safer treatments because they do not affect normal cells, cancer is a very complex disease to be eradicated with a single targeted drug. Alternatively, multi-targeted drugs may be more effective
Glòria García-Galindo +6 more
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Bovine Pancreatic Ribonuclease: 50 Years of the First Enzymatic Reaction Mechanism
Biochemistry, 2011 Fifty years ago, the group of Tony Mathias and Bob Rabin at University College London, deduced the first mechanism for catalysis by an enzyme—ribonuclease (Findlay, D., Herries, D. G., Mathias, A. P., Rabin, B. R., and Ross, C.A. (1961).
C. M. Cuchillo +2 more
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