Results 21 to 30 of about 12,408 (251)

Functional role of glutamine 28 and arginine 39 in double stranded RNA cleavage by human pancreatic ribonuclease. [PDF]

PLoS ONE, 2011
Human pancreatic ribonuclease (HPR), a member of RNase A superfamily, has a high activity on double stranded (ds) RNA. By virtue of this activity HPR appears to be involved in the host-defense against pathogenic viruses.
Md Tabish Rehman, Punyatirtha Dey, Md Imtaiyaz Hassan, Faizan Ahmad, Janendra K Batra   +4 more
doaj   +1 more source

The Selectivity for Tumor Cells of Nuclear-Directed Cytotoxic RNases Is Mediated by the Nuclear/Cytoplasmic Distribution of p27^KIP1

Molecules, 2021
Although single targeted anti-cancer drugs are envisaged as safer treatments because they do not affect normal cells, cancer is a very complex disease to be eradicated with a single targeted drug. Alternatively, multi-targeted drugs may be more effective
Glòria García-Galindo, Jessica Castro, Jesús Matés, Marlon Bravo, Marc Ribó, Maria Vilanova, Antoni Benito   +6 more
doaj   +1 more source

Bovine Pancreatic Ribonuclease: 50 Years of the First Enzymatic Reaction Mechanism

Biochemistry, 2011
Fifty years ago, the group of Tony Mathias and Bob Rabin at University College London, deduced the first mechanism for catalysis by an enzyme—ribonuclease (Findlay, D., Herries, D. G., Mathias, A. P., Rabin, B. R., and Ross, C.A. (1961).
C. M. Cuchillo, M. Nogués, Ronald T. Raines   +2 more
semanticscholar   +1 more source

Giraffe pantheatic ribonuclease [PDF]

, 1975
Comparative studies of proteins may not only provide inforrnatlon on the evolutlon, but also on the structure function relationship of these proteins. Here the isolation and purification of the ribonuclease from giraffe pancreas is reported.
Gaastra, Willem, Gaastra, Willem,
core   +3 more sources

Extraction of high-quality RNA from mouse pancreatic tumors

MethodsX, 2020
Extraction of high-quality RNA from pancreatic tumors for sequencing purposes is technically challenging, as the pancreas is an organ rich in ribonucleases.
Kranthi Kumar Chougoni, Steven R. Grossman   +1 more
doaj   +1 more source

Bovine Pancreatic RNase A: An Insight into the Mechanism of Antitumor Activity In Vitro and In Vivo

Pharmaceutics, 2022
In this investigation, we extensively studied the mechanism of antitumor activity of bovine pancreatic RNase A. Using confocal microscopy, we show that after RNase A penetration into HeLa and B16 cells, a part of the enzyme remains unbound with the ...
Islam Saber Ead Mohamed, Aleksandra V. Sen’kova, Oleg V. Markov, Andrey V. Markov, Innokenty A. Savin, Marina A. Zenkova, Nadezhda L. Mironova   +6 more
doaj   +1 more source

Revisiting the Formation of a Native Disulfide Bond: Consequences for Protein Regeneration and Beyond

Molecules, 2020
Oxidative protein folding involves the formation of disulfide bonds and the regeneration of native structure (N) from the fully reduced and unfolded protein (R).
Mahesh Narayan
doaj   +1 more source

Preliminary investigation of deoxyoligonucleotide binding to ribonuclease A using mass spectrometry: An attempt to develop a lab experience for undergraduates [version 2; referees: 2 approved]

F1000Research, 2018
Deoxyoligonucleotide binding to bovine pancreatic ribonuclease A (RNase A) was investigated using electrospray ionization ion-trap mass spectrometry (ESI-IT-MS). Deoxyoligonucleotides included CCCCC (dC5) and CCACC (dC2AC2).
Daniel D. Clark
doaj   +1 more source

Construction of an RNA-Binding Protein-Related Prognostic Model for Pancreatic Adenocarcinoma Based on TCGA and GTEx Databases

Frontiers in Genetics, 2021
Background: Recently, RNA-binding proteins (RBPs) were reported to interact with target mRNA to regulate gene posttranscriptional expression, and RBP-mediated RNA modification can regulate the expression and function of proto-oncogenes and tumor ...
Xin Wen, Zhiying Shao, Zhiying Shao, Shuyi Chen, Wei Wang, Yan Wang, Jinghua Jiang, Qinggong Ma, Longzhen Zhang, Longzhen Zhang, Longzhen Zhang   +10 more
doaj   +1 more source

Human pancreatic ribonuclease: deletion of the carboxyl-terminal EDST extension enhances ribonuclease activity and thermostability [PDF]

, 1997
Mammalian ribonucleases constitute one of the fastest evolving protein families in nature. The addition of a four-residue carboxyl-terminal tail: Glu-Asp-Ser-Thr (EDST) in human pancreatic ribonuclease (HPR) in comparison with bovine pancreatic RNase ...
Harshawardhan P. Bal, Batra, Janendra K., Janendra K. Batra, Bal, Harshawardhan P.   +3 more
core   +1 more source