Results 121 to 130 of about 80,368 (300)

denaturation of ribonuclease T1. A DSC Study

, 1992
The thermal denaturation of microbial Ribonuclease T1 (RNAase T1) as a function of pH, was studied by means of DSC microcalorimetry. The midpoint denaturation temperatures, enthalpy changes and heat capacity changes of Ribonuclease T1 were compared with ...
G. Graziano, A. Riccio, D. Fessas, P. Del Vecchio, P. Pucci, G. Barone, M. Ruoppolo, C. Giancola   +7 more
core   +1 more source

Paternal Circadian Disruption Impairs Offspring Cognition via Sperm microRNAs

Advanced Science, EarlyView.
Paternal circadian disruption remodels the sperm small RNA payload, elevating miR‐92a‐3p/miR‐25‐3p levels and perturbing early embryonic gene regulatory programs. Microinjection experiments and single‐embryo transcriptomics reveal sex‐specific developmental vulnerabilities, ultimately impairing offspring hippocampal synaptic plasticity and cognition ...
Kexin Zou, Sisi Luo, Binliang Tang, Zhiqiang Liu, Yuchuan Zhou, Yicong Meng, Zhengmu Wu, Zheng Sun, Weihui Shi, Jianzhong Sheng, Chuanjin Yu, Zhenhua Li, Siyi Wei, Mo Zhang, Yujie Luo, Jing Yan, Xueyun Qin, Jiahang Mo, Chengliang Zhou, Jinsong Li, Hefeng Huang, Yifu Ding, Guolian Ding   +22 more
wiley   +1 more source

Genome‐Wide CRISPR Screen Identifies a microRNA Orchestrating Pleiotropic Resistance to Targeted Therapy and T Cell Immunity in Melanoma

Advanced Science, EarlyView.
A genome‐wide microRNA CRISPR screen identifies miR‐18a as a master regulator of cross‐resistance in melanoma. Loss of miR‐18a activates the AJUBA–YAP/Hippo axis to confer BRAFi resistance and enhances THBS1–CD47 interaction to impair CD8+ T cell immunity. hnRNP A1 is identified as an upstream regulator of miR‐18a processing.
Zhao Wang, Haotian Liu, Xueqi Wang, Jianjin Teng, Zihan Zheng, Jingya Zhang, Wanyi Xiao, Qian Liang, Jiaxin Li, Xiaomeng Jia, Xin Feng, Hongzhang Cui, Menghan Luo, Tielong Yang, Liuxing Wu, Ke Zhao, Weilong Yang, Mulin Jun Li, Dandan Huang, Jilong Yang   +19 more
wiley   +1 more source

Inhibition of Tumor-induced Angiogenesis by Ribonuclease Inhibitor

, 1992
The effect of recombinant ribonuclease inhibitor on angiogenesis induced by B16-F10 cells was examined in syngeneic mice. Ribonuclease inhibitor coated with a slow release substance caused a marked decrease of the number of vessels toward tumor mass ...
Mitaka, Toshihiro, Norioka, Kenichi, Mochizuki, Yohichi   +2 more
core   +1 more source

Targeting the PDK1/c‐Myc/SOX10 Signaling in Oligodendrocytes Alleviates Neuropathic Pain

Advanced Science, EarlyView.
This work reveals that oligodendrocyte homeostasis, mediated by PDK1, is a critical determinant of neuropathic pain (NPP) pathogenesis. Disruption of PDK1 in oligodendrocytes impairs SOX10‐dependent myelination programs through c‐Myc accumulation, leading to disrupted myelination and the pathophysiology of NPP.
Pingping Qiao, Lifang Guo, Guochao Yang, Chaoli Huang, He Wang, Jian‐Jun Yang, Guiquan Chen, Yimin Hu   +7 more
wiley   +1 more source

[Structure-dependent differential susceptibility of poly(A) to pancreatic ribonuclease and to ribonuclease BS-1]

, 1976
Structure-dependent differential susceptibility of poly(A) to pancreatic ribonuclease and to ribonuclease BS-
Libonati M., Palmieri M.
core  

PRMT1‐Mediated LDHA Methylation Drives STAT3 Lactylation to Orchestrate Intestinal Inflammation and Tumorigenesis

Advanced Science, EarlyView.
This study identifies an immunometabolic axis wherein SAM‐driven PRMT1 methylates LDHA, enhancing its activity. The resultant lactate induces STAT3 K709 lactylation, which stabilizes an active conformation to promote STAT3 phosphorylation and IL‐10 expression.
Hui Wang, Mengyu Zhang, Weipeng Gong, Jiaxuan Wu, Junping Zhang, Wenxiu Zhang, Yue Liu, Kui Wang, Canhua Huang, Jun Zhou, Sijin Wu, Yan Li, Tianliang Li   +12 more
wiley   +1 more source

Urinary ribonuclease excretion in pancreatic disease.

, 1983
Urinary ribonuclease output and indices of renal tubular integrity were evaluated in control subjects and patients with pancreatic cancer, chronic pancreatitis and extrapancreatic diseases.
FABRIS C., VIANELLO, DANIELA, PICCOLI, ANTONIO, DEL FAVERO G., MEANI A., NACCARATO R., BONVICINI P., FARINI R., BROSOLO P.   +8 more
core  

The degradation by ribonuclease of substrates other than ribonucleic acid

, 1954
These experiments support the premise which is the basis for cytochemical procedures that employ ribonuclease for the identification of ribonucleic acid, namely, that the substrate specifically degraded by ribonuclease is ribonucleic acid.
Kaufmann, B. P., BERWIND P. KAUFMANN, McDonald, M.R., MARGARET R. MCDONALD   +3 more
core   +1 more source

Defining the networks that connect RNase III and RNase J-mediated regulation of primary and specialized metabolism in Streptomyces venezuelae

Journal of Bacteriology
RNA metabolism involves coordinating RNA synthesis with RNA processing and degradation. Ribonucleases play fundamental roles within the cell, contributing to the cleavage, modification, and degradation of RNA molecules, with these actions ensuring ...
Meghan A. D. Pepler, Emma L. Mulholland, Freddie R. Montague, Marie A. Elliot   +3 more
doaj   +1 more source