Results 161 to 170 of about 145,501 (289)

Enzymatic Activity of Polyalanyl Ribonuclease

, 1963
Daniel Wellner, H.I. Silman, Michael Sela   +2 more
openalex   +1 more source

Extracellular Vesicle‐Delivered tRF‐His‐GTG‐1 Reprograms Neutrophil Lipophagy and Triggers Inflammation in COVID‐19

Advanced Science, EarlyView.
This study identifies platelet‐derived extracellular vesicles as key immunometabolic regulators in COVID‐19. The delivery of tRF‐His‐GTG‐1 to neutrophils activates TLR8mTOR signaling, disrupts lipophagy, and amplifies NET‐mediated inflammation. Importantly, targeting this axis restores neutrophil homeostasis, offering a potential therapeutic strategy ...
Tsai‐Ling Liao, Po‐Yu Liu, Yi‐Ming Chen, Kuo‐Tung Tang, Hung‐Jen Liu, Der‐Yuan Chen   +5 more
wiley   +1 more source

A ribonuclease T2 protein FocRnt2 contributes to the virulence of Fusarium oxysporum f. sp. cubense tropical race 4 [PDF]

Yanqiu He, Peng-Fei Li, Xiaoshu Zhou, Shaukat Ali, Jie Zhu, Yini Ma, Jieling Li, Nan Zhang, Huaping Li, Yunfeng Li, Yanfang Nie   +10 more
openalex   +1 more source

ZNRD2 Mediated Nucleoprotein Aggregation Impairs Respiratory Syncytial Virus Replication

Advanced Science, EarlyView.
During RSV infection, nucleoprotein (N) forms RNA‐bound oligomers. The host protein ZNRD2 binds to these oligomers, promoting their transition into insoluble aggregates. These aggregates simultaneously sequester functional N to restrict viral production and disrupt chaperonin assembly quality control by interfering with ZNRD2's role as an adaptor ...
Haiwu Zhou, Mingbin He, Jinhong Du, Cong Liu, Weiwei Wang, Yuewen Han, Zhifei Li, Yali Qin, Mingzhou Chen   +8 more
wiley   +1 more source

Correction for Woodson et al., "Efficacy and <i>in vitro</i> pharmacological assessment of novel <i>N</i>-hydroxypyridinediones as hepatitis B virus ribonuclease H inhibitors". [PDF]

Antimicrob Agents Chemother
Woodson ME, Walden HF, Mottaleb MA, Makri M, Prifti G-M, Moianos D, Pardali V, Zoidis G, Tavis JE.   +8 more
europepmc   +1 more source

Nurr1 Orchestrates Claustrum Development and Functionality

Advanced Science, EarlyView.
Nurr1 (Nr4a2) is the master transcription factor to control claustrum morphogenesis and cell fate decision postmitotically by inhibiting intracellular G‐protein signaling. Nurr1 deficiency alters the transcriptomic profiles of subcortical claustral neurons into neocortical insular neurons, resulting in defected claustrum development, impaired axonal ...
Kuo Yan, Andrew G. Newman, Pauline Lange, Susanne Müller, Marco Foddis, Stefan Paul Koch, Philipp Böhm‐Sturm, Maron Mantwill, Carsten Finke, Penghui Deng, Melissa Long, Dietmar Schmitz, Victor Tarabykin   +12 more
wiley   +1 more source

YhfH functions as a tri-function RNA in Bacillus thuringiensis BMB171. [PDF]

Nucleic Acids Res
Qin J, Cai X, Zhang Y, Wang Z, Pan F, Yan B, Cai J.   +6 more
europepmc   +1 more source

Regulation of poly(a)-specific ribonuclease activity by reversible lysine acetylation [PDF]

, 2020
Eden A. Dejene, Yixuan Li, Zahra Showkatian, Hongbo Ling, Edward Seto   +4 more
openalex   +1 more source

Decoding Human Placental Cellular and Molecular Responses to Obesity and Fetal Growth

Advanced Science, EarlyView.
Women with obesity often deliver large‐for‐gestational‐age (LGA) infants. Single‐nucleus RNA sequencing of term placenta reveals that hypoxia and TNF‐α signaling in syncytiotrophoblasts are featured in maternal obesity, but inflammatory signatures in Hofbauer cells and response to lipid or carbohydrate metabolism in fibroblasts are specific to LGA.
Hong Jiang, Emilie Derisoud, Denise Parreira, Nayere Taebnia, Paulo R. Jannig, Reza Zandi Shafagh, Allan Zhao, Congru Li, Macarena Ortiz, Manuel Alejandro Maliqueo, Elisabet Stener‐Victorin, Volker M. Lauschke, Qiaolin Deng   +12 more
wiley   +1 more source

Functional Analysis of Histidine-Dependent Self-Cleaving RNAs Obtained by In Vitro Selection. [PDF]

Chembiochem
Sakimoto N, Tanaka S, Hatakenaka R, Yamaguchi-Miyazaki Y, Tomita-Sudo E, Akita T, Ishigaki T, Iwai S, Kawakami J.   +8 more
europepmc   +1 more source