Results 81 to 90 of about 156,401 (384)

Host-induced gene silencing in barley powdery mildew reveals a class of ribonuclease-like effectors.

Molecular Plant-Microbe Interactions, 2013
Obligate biotrophic pathogens of plants must circumvent or counteract defenses to guarantee accommodation inside the host. To do so, they secrete a variety of effectors that regulate host immunity and facilitate the establishment of pathogen feeding ...
C. Pliego, D. Nowara, Giulia Bonciani, Dana M Gheorghe, Ruo Xu, P. Surana, Ehren Whigham, D. Nettleton, A. Bogdanove, R. Wise, P. Schweizer, L. Bindschedler, P. Spanu   +12 more
semanticscholar   +1 more source

Transcriptome‐wide analysis of circRNA and RBP profiles and their molecular relevance for GBM

Molecular Oncology, EarlyView.
CircRNAs are differentially expressed in glioblastoma primary tumors and might serve as therapeutic targets and diagnostic markers. The investigation of circRNA and RNA‐binding proteins (RBPs) interactions shows that distinct RBPs play a role in circRNA biogenesis and function.
Julia Latowska‐Łysiak, Żaneta Zarębska, Marcin P. Sajek, Adriana Grabowska, Alessia Buratin, Paweł Głodowicz, Julia O. Misiorek, Konrad Kuczyński, Stefania Bortoluzzi, Marek Żywicki, Jan G. Kosiński, Agnieszka Rybak‐Wolf, Rafał Piestrzeniewicz, Anna M. Barciszewska, Katarzyna Rolle   +14 more
wiley   +1 more source

Genetic diversity of human RNase 8

BMC Genomics, 2012
Background Ribonuclease 8 is a member of the RNase A family of secretory ribonucleases; orthologs of this gene have been found only in primate genomes. RNase 8 is a divergent paralog of RNase 7, which is lysine-enriched, highly conserved, has prominent ...
Chan Calvin C, Moser Jennifer M, Dyer Kimberly D, Percopo Caroline M, Rosenberg Helene F   +4 more
doaj   +1 more source

BLISTER-regulated vegetative growth is dependent on the protein kinase domain of ER stress modulator IRE1A in Arabidopsis thaliana [PDF]

, 2019
The unfolded protein response (UPR) is required for protein homeostasis in the endoplasmic reticulum (ER) when plants are challenged by adverse environmental conditions.
Hong, Zheng-Hui, Kleinmanns, Julia Anna, Liu, Jian-Xiang, Qing, Tao, Schubert, Daniel   +4 more
core   +1 more source

The Synthesis of Ribonuclease A

Journal of Biological Chemistry, 1971
A protected linear polypeptide of 124 amino acid residues with the sequence of bovine pancreatic ribonuclease A was synthesized by the solid phase method. The polypeptide was removed from the solid support and purified, and the four disulfide bonds were closed by air oxidation of the reduced form. The synthetic enzyme was fractionated by gel filtration
Bernd Gutte, R. B. Merrifield
openaire   +3 more sources

Multidimensional OMICs reveal ARID1A orchestrated control of DNA damage, splicing, and cell cycle in normal‐like and malignant urothelial cells

Molecular Oncology, EarlyView.
Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser, Florian Krumbach, Eyleen Corrales, Geoffroy Andrieux, Christian Preisinger, Franziska Liss, Alexandra Golzmann, Melanie Boerries, Kerstin Becker, Ruth Knüchel, Stefan Garczyk, Bernhard Lüscher   +11 more
wiley   +1 more source

The Hepatitis B Virus Ribonuclease H Is Sensitive to Inhibitors of the Human Immunodeficiency Virus Ribonuclease H and Integrase Enzymes

PLoS Pathogens, 2013
Nucleos(t)ide analog therapy blocks DNA synthesis by the hepatitis B virus (HBV) reverse transcriptase and can control the infection, but treatment is life-long and has high costs and unpredictable long-term side effects.
J. Tavis, Xiaohong Cheng, Yuan Hu, Michael Totten, F. Cao, E. Michailidis, R. Aurora, M. Meyers, E. Jacobsen, M. Parniak, S. Sarafianos   +10 more
semanticscholar   +1 more source

Cationic poly(amidoamine) promotes cytosolic delivery of bovine RNase A in melanoma cells, while maintaining its cellular toxicity [PDF]

, 2015
Ribonucleases are known to cleave ribonucleic acids, inducing cell death. RNase A, a member of the ribonuclease family, generally displayed poor in vitro activity. This has been attributed to factors such as low intracellular delivery.
Akinc, Almeida, Berisio, Cafaro, Chao, Cohen, Coué, Coué, De Lorenzo, Di Donato, Ding, Dubois, Ellis, Ercole, Ferruti, Foglia, Futami, Futami, Futami, Hattori, Hunter, Iversen, Ivinova, Karayianni, Larsericsdotter, Lavignac, Lavignac, Lavignac, Ledoux, Lee, Leich, Leland, Lienqueo, Liu, Lo, Mahn, Matousek, Mattison, Nicholson, Parhamifar, Parhamifar, Pattrick, Peng, Pfeil, Pouckova, Pouckova, Richardson, Romanini, Sasisanker, Saxena, Sedlak, Seyrek, Smith, Tribet, van de Weert, Vottariello, Wang, Wilson, Xia, Yeo, Zhang   +60 more
core   +1 more source

Escape from TGF‐β‐induced senescence promotes aggressive hallmarks in epithelial hepatocellular carcinoma cells

Molecular Oncology, EarlyView.
Chronic TGF‐β exposure drives epithelial HCC cells from a senescent state to a TGF‐β resistant mesenchymal phenotype. This transition is characterized by the loss of Smad3‐mediated signaling, escape from senescence, enhanced invasiveness and metastatic potential, and upregulation of key resistance modulators such as MARK1 and GRM8, ultimately promoting
Minenur Kalyoncu, Dilara Demirci, Sude Eris, Bengisu Dayanc, Ece Cakiroglu, Merve Basol, Merve Uysal, Gulcin Cakan‐Akdogan, Fang Liu, Mehmet Ozturk, Gökhan Karakülah, Serif Senturk   +11 more
wiley   +1 more source

NaPi/SX-RNase segregates as a functional S-RNase and is induced under phosphate deficiency in Nicotiana alata

Biologia Plantarum, 2018
In plants, class III T2 RNases involves two groups of structurally similar proteins, but with different biological functions: S-RNases and non-S-RNases.
H. J. Rojas, C. Caspani, E. G. Escobar, R. Quiroga, A. Goldraij   +4 more
doaj   +1 more source