A murine monoclonal antibody recognizes the 13,000 molecular weight polypeptide of the Sm small nuclear ribonucleoprotein complex. [PDF]
, 1985 Peter B. Billings +2 more
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Advanced Science, EarlyView.This study presents a novel strategy for periodontitis treatment by co‐delivering a membrane‐ and ribosome‐targeting antimicrobial peptide GF and Irisin through a pH‐responsive metal‐organic framework. The system enables sequential release, providing rapid antibacterial action, anti‐inflammatory and antioxidative effects, as well as promoting bone ...
Yan Chen +10 more
wiley +1 more source
The Proximal Region of the 3′-Untranslated Region of Cyclooxygenase-2 is Recognized by a Multimeric Protein Complex Containing HuR, TIA-1, TIAR, and the Heterogeneous Nuclear Ribonucleoprotein U [PDF]
, 2003 Steven J. Cok +2 more
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Engineering Immune Cell to Counteract Aging and Aging‐Associated Diseases
Advanced Science, EarlyView.This review highlights a paradigm shift in which advanced immune cell therapies, initially developed for cancer, are now being harnessed to combat aging. By engineering immune cells to selectively clear senescent cells and remodel pro‐inflammatory tissue microenvironments, these strategies offer a novel and powerful approach to delay age‐related ...
Jianhua Guo +5 more
wiley +1 more source
Transposable Elements, Inflammation, and Neurological Disease. [PDF]
, 2019 Transposable Elements (TE) are mobile DNA elements that can replicate and insert themselves into different locations within the host genome. Their propensity to self-propagate has a myriad of consequences and yet their biological significance is not well-
Macia, Angela +2 more
core
Generating golden Syrian hamsters with conditional alleles via zygote microinjection of CRISPR/Cas9
Animal Models and Experimental Medicine, EarlyView.We established the first conditional knockout (cKO) model in the golden Syrian hamster by CRISPR/Cas9‐mediated genome editing. Cas9 protein, two sgRNAs, and a donor plasmid carrying loxP‐flanked exon 2 of the ApoF gene were microinjected into one‐cell embryos. The floxed allele was efficiently generated (up to 27%) and transmitted through the germline.
Wei Chen +16 more
wiley +1 more source
Dysregulated ribonucleoprotein granules promote cardiomyopathy in RBM20 gene-edited pigs
Nature Medicine, 2020 J. Schneider +42 more
semanticscholar +1 more source
U5 small nuclear ribonucleoprotein: RNA structure analysis and ATP-dependent interaction with U4/U6.
, 1989 Douglas L. Black, A L Pinto
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Annals of Neurology, EarlyView.Objective Mutations in TARDBP (encoding TDP‐43) are associated with the neurodegenerative disease amyotrophic lateral sclerosis (ALS) and include familial missense mutations where there are a lack of models and mechanisms examining how they are pathogenic.
Ziyaan A. Harji +10 more
wiley +1 more source