Results 201 to 210 of about 121,107 (346)

Small Nuclear Ribonucleoprotein Autoantibody Associated With Blood-Nerve Barrier Breakdown in Guillain-Barré Syndrome. [PDF]

open access: yesNeurol Neuroimmunol Neuroinflamm
Shimizu F   +8 more
europepmc   +1 more source

A cellular model of TDP‐43 induces phosphorylated TDP‐43 aggregation with distinct changes in solubility and autophagy dysregulation

open access: yesThe FEBS Journal, EarlyView.
TDP‐43 protein plays a pathological role in sporadic and familial amyotrophic lateral sclerosis (ALS). Here, we developed a cellular model overexpressing TDP‐43 with three mutations linked to familial ALS, termed ‘3X‐TDP‐43’. Mutant 3X‐TDP‐43 expression showed deficits in autophagy flux and colocalization with stress granules.
Matthew B. Dopler   +20 more
wiley   +1 more source

Past, present, and future strategies for detecting and quantifying circular RNA variants

open access: yesThe FEBS Journal, EarlyView.
Originally considered artifact of RNA splicing, over 3 million circular RNAs have been found in humans alone through a combination of ultrasensitive detection methods and bespoke bioinformatics tools. This review covers past, present, and future strategies for detecting and quantifying circular RNAs and how they are illuminating novel circular RNA ...
He Lin, Vanessa M. Conn, Simon J. Conn
wiley   +1 more source

The G protein‐coupled receptor GPR89A is a novel potential therapeutic target to overcome cisplatin resistance in NSCLC Calu1 cells

open access: yesThe FEBS Journal, EarlyView.
A genome‐wide CRISPR‐Cas9‐based genetic screen in cisplatin‐resistant NSCLC cells revealed 63 potential candidate genes for overcoming cisplatin resistance, including GPR89A. GPR89A, localised in the Golgi, modulates voltage‐gated anion channel activity and is involved in intracellular pH reduction.
Hale Guler Kara   +9 more
wiley   +1 more source

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