Results 351 to 360 of about 144,340 (386)
Some of the next articles are maybe not open access.
Biomaterials Science, 2020
CRISPR-Cas9 is a versatile genome-editing technology that is a promising gene therapy tactic. However, the delivery of CRISPR-Cas9 is still a major obstacle to its broader clinical application.
Yangyang Ye +11 more
semanticscholar +1 more source
CRISPR-Cas9 is a versatile genome-editing technology that is a promising gene therapy tactic. However, the delivery of CRISPR-Cas9 is still a major obstacle to its broader clinical application.
Yangyang Ye +11 more
semanticscholar +1 more source
The SMN complex, an assemblyosome of ribonucleoproteins
Current Opinion in Cell Biology, 2002Spinal muscular atrophy is a common, often lethal, neurodegenerative disease that results from low levels of, or loss-of-function mutations in, the SMN (survival of motor neurons) protein. SMN oligomerizes and forms a stable complex with five additional proteins: Gemins 2-6. SMN also interacts with several additional proteins referred to as "substrates"
Paushkin, Sergey +3 more
openaire +4 more sources
Small Cytoplasmic Ribonucleoproteins
2013It is now well established that most RNAs are tightly associated with one or more proteins to generate nuclear or cytoplasmic ribonucleoprotein (RNP) complexes. Over 30 years ago, Lerner, Steitz, and coworkers found that the proteic components of these complexes made up some of the antigens recognized by sera of patients affected by systemic lupus ...
ROMANO, MAURIZIO, BURATTI, EMANUELE
openaire +2 more sources
Biochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis, 1974
Various species of rapidly labelled, informational ribonucleoproteins can be isolated from homogenates of newt oocytes. Polyribosome-associated ribonucleoprotein can be separated from heterogeneous nuclear ribonucleoprotein and free cytoplasmic ribonucleoprotein by sucrose gradient centrifugation.
openaire +3 more sources
Various species of rapidly labelled, informational ribonucleoproteins can be isolated from homogenates of newt oocytes. Polyribosome-associated ribonucleoprotein can be separated from heterogeneous nuclear ribonucleoprotein and free cytoplasmic ribonucleoprotein by sucrose gradient centrifugation.
openaire +3 more sources
ENZYMATIC DEGRADATION OF RIBONUCLEOPROTEINS
American Journal of Botany, 1951THE ACTION of crystalline enzymes in degrading cellular substrates of fixed tissues can be determined by suitable staining procedures. Thus, as Brachet (1940) has shown, tissues that have been incubated in ribonuclease and then stained with Unna's combination of methyl green and pyronin show little or no color in cytoplasm and nucleoli, whereas these ...
Berwind P. Kaufmann +2 more
openaire +2 more sources
Archives of Biochemistry and Biophysics, 1986
A cytoplasmic 10S ribonucleoprotein particle (iRNP), which is isolated from chick embryonic muscle, is a potent inhibitor of mRNA translation in vitro and contains a 4S translation inhibitory RNA species (iRNA). The iRNP particle shows similarity in size to the small nuclear ribonucleoprotein (snRNP) particles.
Dipak Chakraborty +6 more
openaire +3 more sources
A cytoplasmic 10S ribonucleoprotein particle (iRNP), which is isolated from chick embryonic muscle, is a potent inhibitor of mRNA translation in vitro and contains a 4S translation inhibitory RNA species (iRNA). The iRNP particle shows similarity in size to the small nuclear ribonucleoprotein (snRNP) particles.
Dipak Chakraborty +6 more
openaire +3 more sources
Ribonucleoproteins of Uukuniemi virus are circular [PDF]
Journal of Virology, 1975 The internal ribonucleoprotein (RNP) of Uukuniemi virus was released with Triton X-100 and analyzed on sucrose gradients. Three species of RNP sedimenting at 140 to 150, 105 to 120, and 85 to 90S could be separated. All of them contained the same ratio of core polypeptide (mol wt, 25,000) to RNA. Eelctron microscopy using rotatory shadowing showed that
C H von Bonsdorff, Ralf F. Pettersson
openaire +2 more sources
The Phlebovirus Ribonucleoprotein: An Overview
In negative strand RNA viruses, ribonucleoproteins, not naked RNA, constitute the template used by the large protein endowed with polymerase activity for replicating and transcribing the viral genome. Here we give an overview of the structures and functions of the ribonucleoprotein from phleboviruses.Ferron, François, Lescar, Julien
openaire +3 more sources
CHARACTERIZATION OF BRAIN RIBONUCLEOPROTEIN PARTICLES
Journal of Neurochemistry, 1979Abstract— Brain RNP particles were characterized to determine whether they play a role in the regulation of brain protein synthesis. RNP particles were isolated from the postribosomal supernatant of cerebral hemispheres of young rabbits, employing conditions which minimize adventitious protein‐RNA interactions.
James B. Mahony, Ian R. Brown
openaire +3 more sources
Biogenesis of small nucleolar ribonucleoproteins
Current Opinion in Cell Biology, 2002Eukaryotic cells contain a very complex population of small nucleolar RNAs. They function, as small nucleolar ribonucleoproteins, in pre-ribosomal RNA processing reactions, and also guide methylation and pseudouridylation of ribosomal RNA, spliceosomal small nuclear RNAs, and possibly other cellular RNAs.
Vanda Pogacic, Witold Filipowicz
openaire +3 more sources