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Structural studies of protein–nucleic acid complexes: A brief overview of the selected techniques
Computational and Structural Biotechnology Journal, 2023 Protein–nucleic acid complexes are involved in all vital processes, including replication, transcription, translation, regulation of gene expression and cell metabolism.
Kamil Szpotkowski +2 more
doaj
Delayed kinetics of poliovirus RNA synthesis in a human cell line with reduced levels of hnRNP C proteins. [PDF]
, 2010 The hnRNP C heterotetramer [(C1(3))C2] binds RNA polymerase II transcripts in the nucleus, along with other proteins of the core hnRNP complex, and plays an important role in mRNA biogenesis and transport.
Brunner, Jo Ellen +3 more
core +1 more source
The synthesis of hemoglobin in a cell-free system [PDF]
, 1958 The microsomal particles (1) have been implicated as the major sites of protein synthesis within the cells of a variety of tissues. The studies of Borsook, Zamecnik, Hultin, and others, with intact animals and various types of whole cell systems (see ...
Allen, Esther +2 more
core +2 more sources
Frontiers in Plant Science, 2020 The genetic engineering method CRISPR has been touted as an efficient, inexpensive, easily used, and targeted genetic modification technology that is widely suggested as having the potential to solve many of the problems facing agriculture now and in the
Kali M. Brandt +3 more
doaj +1 more source
Synthetic gRNA/Cas9 Ribonucleoprotein Inhibits HIV Reactivation and Replication
Viruses, 2022 The current antiretroviral therapy (ART) for human immunodeficiency virus (HIV) can halt viral replication but cannot eradicate HIV infection because proviral DNA integrated into the host genome remains genetically silent in reservoir cells and is ...
Sushant Khanal +14 more
doaj +1 more source
Characterization of nuclear polyadenylated RNA-binding proteins in Saccharomyces cerevisiae. [PDF]
, 1994 To study the functions of heterogeneous nuclear ribonucleoproteins (hnRNPs), we have characterized nuclear polyadenylated RNA-binding (Nab) proteins from Saccharomyces cerevisiae.
Datar, KV +4 more
core +1 more source
Highly Efficient, Rapid and Co-CRISPR-Independent Genome Editing in Caenorhabditis elegans
G3: Genes, Genomes, Genetics, 2017 We describe a rapid and highly efficient method to generate point mutations in Caenorhabditis elegans using direct injection of CRISPR-Cas9 ribonucleoproteins.
Harriet Prior +3 more
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HIV-1 Recruits UPF1 but Excludes UPF2 to Promote Nucleocytoplasmic Export of the Genomic RNA
Biomolecules, 2015 Unspliced, genomic HIV-1 RNA (vRNA) is a component of several ribonucleoprotein complexes (RNP) during the viral replication cycle. In earlier work, we demonstrated that the host upframeshift protein 1 (UPF1), a key factor in nonsense-mediated mRNA decay
Lara Ajamian +8 more
doaj +1 more source
Neural Regeneration Research, 2023 Heterogenous nuclear ribonucleoprotein G is down-regulated in the spinal cord of the Tg(SOD1*G93A)1Gur (TG) amyotrophic lateral sclerosis mouse model.
Fang Yang +4 more
doaj +1 more source
Drug hypersensitivity caused by alteration of the MHC-presented self-peptide repertoire [PDF]
, 2012 Idiosyncratic adverse drug reactions are unpredictable, dose independent and potentially life threatening; this makes them a major factor contributing to the cost and uncertainty of drug development. Clinical data suggest that many such reactions involve
A. Lucas +47 more
core +4 more sources