Results 51 to 60 of about 121,107 (346)

Dissection of affinity captured LINE-1 macromolecular complexes

eLife, 2018
Long Interspersed Nuclear Element-1 (LINE-1, L1) is a mobile genetic element active in human genomes. L1-encoded ORF1 and ORF2 proteins bind L1 RNAs, forming ribonucleoproteins (RNPs).
Martin S Taylor, Ilya Altukhov, Kelly R Molloy, Paolo Mita, Hua Jiang, Emily M Adney, Aleksandra Wudzinska, Sana Badri, Dmitry Ischenko, George Eng, Kathleen H Burns, David Fenyö, Brian T Chait, Dmitry Alexeev, Michael P Rout, Jef D Boeke, John LaCava   +16 more
doaj   +1 more source

The molecular chaperone Hsp90 is a component of the cap-binding complex and interacts with the translational repressor Cup during Drosophila oogenesis [PDF]

, 2009
In metazoa, the spatio-temporal translation of diverse mRNAs is essential to guarantee proper oocyte maturation and early embryogenesis. The eukaryotic translation initiation factor 4E (eIF4E), which binds the 5′ cap structure of eukaryotic mRNAs ...
COZZOLINO M., GARGIULO S., GIGLIOTTI S., GRAZIANI F., MONTI, MARIA, OTTONE, CRISTINA, PICCIONI F., PISA, VIVIANA, PUCCI, PIETRO, TALAMO F., VERROTTI DI PIANELLA, ARTURO   +10 more
core   +1 more source

Large-scale remodeling of a repressed exon ribonucleoprotein to an exon definition complex active for splicing

eLife, 2016
Polypyrimidine-tract binding protein PTBP1 can repress splicing during the exon definition phase of spliceosome assembly, but the assembly steps leading to an exon definition complex (EDC) and how PTBP1 might modulate them are not clear.
Somsakul Pop Wongpalee, Ajay Vashisht, Shalini Sharma, Darryl Chui, James A Wohlschlegel, Douglas L Black   +5 more
doaj   +1 more source

Protein or ribonucleoprotein-mediated blocking of recombinase polymerase amplification enables the discrimination of nucleotide and epigenetic differences between cell populations

Communications Biology, 2021
Fujita et al. investigate the use of oligoribonucleotides, proteins, and ribonucleoprotein complexes as sequence-specific blockers of DNA extension by DNA polymerases.
Toshitsugu Fujita, Shoko Nagata, Hodaka Fujii   +2 more
doaj   +1 more source

Analysis of the extranucleolar ribonucleoprotein particles of Cycas revoluta Thunb. (Cycadaceae) and Ceratozamia mexicana Brongn. (Zamiaceae)

Botan‪ical Sciences, 2022
Background: Nuclear ribonucleoprotein particles play a key role in RNA processing and in the gene expression pathway. Interchromatin granules (GICs) involved in the metabolism of pre-messenger RNA (pre-mRNA) were described in Allium cepa and ...
Lourdes-Teresa Agredano-Moreno, María de Lourdes Segura-Valdez, Jaime Jiménez-Ramírez, Luis-Felipe Jiménez-García   +3 more
doaj   +1 more source

Proteomic identification of heterogeneous nuclear ribonucleoprotein L as a novel component of SLM/Sam68 nuclear bodies [PDF]

, 2009
Background: Active pre-mRNA splicing occurs co-transcriptionally, and takes place throughout the nucleoplasm of eukaryotic cells. Splicing decisions are controlled by networks of nuclear RNA-binding proteins and their target sequences, sometimes in ...
Bindereif, A., Bourgeois, C.F., Clark, E.L., Dalgliesh, C., Elliott, D.J., Emami, K., Heiner, M., Leung, H.Y., Rajan, P., Robson, C.N., Stevenin, J.   +10 more
core   +7 more sources

The human Dicer helicase domain is capable of ATP hydrolysis and single-stranded nucleic acid binding

BMC Biology
Background Vertebrates have one Dicer ortholog that generates both microRNAs (miRNAs) and small interfering RNAs (siRNAs), in contrast to the multiple Dicer-like proteins found in flies and plants.
Kinga Ciechanowska, Agnieszka Szczepanska, Kamil Szpotkowski, Klaudia Wojcik, Anna Urbanowicz, Anna Kurzynska-Kokorniak   +5 more
doaj   +1 more source

Monovalent ions modulate the flux through multiple folding pathways of an RNA pseudoknot [PDF]

, 2017
The functions of RNA pseudoknots (PKs), which are minimal tertiary structural motifs and an integral part of several ribozymes and ribonucleoprotein complexes, are determined by their structure, stability and dynamics. Therefore, it is important to elucidate the general principles governing their thermodynamics/folding mechanisms.
arxiv   +1 more source

The RNA-binding protein hnRNPA2 regulates β-catenin protein expression and is overexpressed in prostate cancer [PDF]

, 2014
The RNA-binding protein hnRNPA2 (HNRNPA2B1) is upregulated in cancer, where it controls alternative pre-mRNA splicing of cancer-relevant genes. Cytoplasmic hnRNPA2 is reported in aggressive cancers, but is functionally uncharacterized.
Ahmad, Imran, Leung, Hing, Nixon, Colin, Rajan, Prabhakar, Stockley, Jacqueline, Villasevil, M. Eugenia M.   +5 more
core   +1 more source

Multidimensional OMICs reveal ARID1A orchestrated control of DNA damage, splicing, and cell cycle in normal‐like and malignant urothelial cells

Molecular Oncology, EarlyView.
Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser, Florian Krumbach, Eyleen Corrales, Geoffroy Andrieux, Christian Preisinger, Franziska Liss, Alexandra Golzmann, Melanie Boerries, Kerstin Becker, Ruth Knüchel, Stefan Garczyk, Bernhard Lüscher   +11 more
wiley   +1 more source