Non-canonical binding interactions of the RNA recognition motif (RRM) domains of P34 protein modulate binding within the 5S ribonucleoprotein particle (5S RNP). [PDF]
PLoS ONE, 2017 RNA binding proteins are involved in many aspects of RNA metabolism. In Trypanosoma brucei, our laboratory has identified two trypanosome-specific RNA binding proteins P34 and P37 that are involved in the maturation of the 60S subunit during ribosome ...
Anyango D Kamina, Noreen Williams
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TAR RNA Mimicry of INI1 and Its Influence on Non-Integration Function of HIV-1 Integrase [PDF]
VirusesHIV-1 integrase (IN), an essential viral protein that catalyzes integration, also influences non-integration functions such as particle production and morphogenesis.
Ganjam V. Kalpana +2 more
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Structure of a transcribing Pol II-DSIF-SPT6-U1 snRNP complex [PDF]
Nature CommunicationsIn eukaryotic cells, splicing occurs predominantly co-transcriptionally, enhancing splicing efficiency and fidelity while introducing an additional layer of regulation over gene expression.
Luojia Zhang +8 more
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CRISPR/Cas9 ribonucleoprotein mediated DNA-free genome editing in larch [PDF]
Forestry ResearchHere, a DNA-free genetic editing approach is presented for larch by delivering ribonucleoprotein complexes (RNPs) of CRISPR/Cas9 through particle bombardment.
Miaomiao Ma +4 more
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Crystal structure of human U1 snRNP, a small nuclear ribonucleoprotein particle, reveals the mechanism of 5′ splice site recognition [PDF]
eLife, 2015 U1 snRNP binds to the 5′ exon-intron junction of pre-mRNA and thus plays a crucial role at an early stage of pre-mRNA splicing. We present two crystal structures of engineered U1 sub-structures, which together reveal at atomic resolution an almost ...
Yasushi Kondo +3 more
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The Broad-Spectrum Antiviral Protein ZAP Restricts Human Retrotransposition. [PDF]
PLoS Genetics, 2015 Intrinsic immunity describes the set of recently discovered but poorly understood cellular mechanisms that specifically target viral pathogens. Their discovery derives in large part from intensive studies of HIV and SIV that revealed restriction factors ...
John L Goodier +4 more
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Group II intron protein localization and insertion sites are affected by polyphosphate. [PDF]
PLoS Biology, 2008 Mobile group II introns consist of a catalytic intron RNA and an intron-encoded protein with reverse transcriptase activity, which act together in a ribonucleoprotein particle to promote DNA integration during intron mobility.
Junhua Zhao +5 more
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Multimodal Functionalities of HIV-1 Integrase
Viruses, 2022 Integrase is the retroviral protein responsible for integrating reverse transcripts into cellular genomes. Co-packaged with viral RNA and reverse transcriptase into capsid-encased viral cores, human immunodeficiency virus 1 (HIV-1) integrase has long ...
Alan N. Engelman, Mamuka Kvaratskhelia
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Cryotomography of budding influenza a virus reveals filaments with diverse morphologies that mostly do not bear a genome at their distal end [PDF]
, 2013 Influenza viruses exhibit striking variations in particle morphology between strains. Clinical isolates of influenza A virus have been shown to produce long filamentous particles while laboratory-adapted strains are predominantly spherical.
A Ali +45 more
core +7 more sources
YRNAs: New Insights and Potential Novel Approach in Head and Neck Squamous Cell Carcinoma
Cells, 2020 YRNAs are a class of non-coding RNAs that are components of the Ro60 ribonucleoprotein particle and are essential for initiation of DNA replication. Ro60 ribonucleoprotein particle is a target of autoimmune antibodies in patients suffering from systemic ...
Kacper Guglas +7 more
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