Results 141 to 150 of about 30,834 (284)

Isolation of cytoplasmic non‐ribosomal ribonucleoprotein particles (informosomes) [PDF]

, 1972
J. Kempf, J.M. Egly, C. Stricker, M. Schmitt, P. Mandel, N. Pfleger   +5 more
openalex   +1 more source

Single‐cell spatial transcriptomic sequencing and machine learning models uncover molecular mechanisms and diagnostic biomarkers of Peyronie's disease formation in rats

VIEW, EarlyView.
Peyronie's disease (PD) is a common male reproductive system disorder. The exact etiology of PD remains unclear. This study aimed to investigate molecular and cellular changes in PD using single‐cell spatial transcriptomics. Abstract Peyronie's disease (PD), commonly known as penile induration, is a prevalent male reproductive system disorder with ...
Keyuan Lou, Qiancheng Mao, Junpeng Chi, Jiankun Zhang, Hao Guo, Jitao Wu, Yuanshan Cui   +6 more
wiley   +1 more source

Strand displacement‐driven CRISPR/Cas12a framework enables precise identification of low‐abundance point mutations

VIEW, EarlyView.
We established an engineered CRISPR/Cas12a point mutation detection strategy (E‐CRISPR) for low‐abundance point mutations detection. By integrating the precise regulatory mechanism of strand displacement reaction (SDR) with the local high‐concentration probe microenvironment created by tetrahedral DNA frameworks (TDFs), it has achieved simultaneous ...
Jiaxi Mo, Yan Zhao, Chenyu Sun, Mingtao Li, Hengyi Chen, Yufang Zhang, Xiaohui Chen, Xinlin Guo, Zhizeng Wang, Yonghong Wang, Jichun Yang, Yang Luo   +11 more
wiley   +1 more source

CRISPR vs. nematodes: A new era of genetic solutions for potato crop protection

Annals of Applied Biology, EarlyView.
This review highlights the impact of nematodes on potato production and explores CRISPR/Cas genome editing as a breakthrough strategy for enhancing resistance. We discuss the potential, challenges, and future directions of CRISPR‐based approaches in developing resilient potato cultivars.
Karam Mostafa, Mohamed Farah Abdulla, Momna Mehmood, Gökhan Aydınlı, Nouraiz Ahmed Tanveer, Walid B. Abdelaal, Musa Kavas   +6 more
wiley   +1 more source

The presence of small molecular weight RNAs in nuclear ribonucleoprotein particles carrying HnRNA [PDF]

, 1977
B Deimel, Louis Ch, Sekeris Ce
openalex   +1 more source

CRISPR Technology in Disease Management: An Updated Review of Clinical Translation and Therapeutic Potential

Cell Proliferation, EarlyView.
CRISPR‐Cas systems offer transformative genome editing capabilities for precise manipulation of cellular genes. This enables two main therapeutic avenues: ex vivo modification of patient cells for re‐transplantation or direct in vivo gene targeting via advanced delivery methods.
Bahareh Farasati Far, Marziyeh Akbari, Mohammad Amin Habibi, Morteza Katavand, Sherko Nasseri   +4 more
wiley   +1 more source

Non-polyadenylated 22 S ribonucleoprotein particle is insensitive to translational inhibitor RNA of cryptobiotic gastrulae of Artemia salina [PDF]

, 1979
Erik De Herdt, Herman Slegers, Etienne Piot, Masatoshi Kondo   +3 more
openalex   +1 more source

In vivo modeling of lethal congenital contracture syndrome 1 suggests pathomechanisms in cellular stress responses

The FEBS Journal, EarlyView.
Gle1 knockout mice fail to segregate cell lineages at the blastocyst stage, resulting in very early embryonic lethality. Gle1 knock‐in (KI) mice harboring a pathogenic variant giving rise to lethal congenital contracture syndrome 1 show both known and novel innervation defects, supportive of multiorgan pathology in human fetuses.
Tomáš Zárybnický, Sonja Lindfors, Saana Metso, Julia Koivula, Zoltan Szabo, Rasmus Valtonen, Mikko Tulppo, Johanna Magga, Samu Saarimäki, Sonja Bläuer, Ilkka Miinalainen, Risto Kerkelä, Petteri. T. Piepponen, Vootele Voikar, Juho Väänänen, Riikka Kivelä, Bhagwan Yadav, Hanna Lindgren, Pirkko Mattila, Fu‐Ping Zhang, Petra Sipilä, Reetta Hinttala, Satu Kuure   +22 more
wiley   +1 more source

Purification of histone messenger ribonucleoprotein particles from He La cell S-phase polysomes. Characterization of associated proteins [PDF]

, 1979
Jean‐Pierre Liautard, Ph. Jeanteur
openalex   +1 more source

SYNCAS‐mediated CRISPR‐Cas9 genome editing in the Jewel wasp, Nasonia vitripennis

Insect Molecular Biology, EarlyView.
Maternal injection of Cas9 RNP together with BAPC and saponins (SYNCAS) results in efficient gene editing of Nasonia vitripennis offspring. The timing of injection and egg collection is important for maximising efficiency and reducing screening effort.
Filippo Guerra, Sander De Rouck, Eveline C. Verhulst   +2 more
wiley   +1 more source