Results 161 to 170 of about 30,834 (284)

Subcellular partitioning of MRP RNA assessed by ultrastructural and biochemical analysis. [PDF]

open access: yes, 1994
A small RNA encoded within the nucleus is an essential subunit of a RNA processing endonuclease (RNase MRP) hypothesized to generate primers for mitochondrial DNA replication from the heavy strand origin of replication.
Gonzalez, M   +6 more
core  

Cell‐Penetrating Peptide‐Based Triple Nanocomplex Enables Efficient Nuclear Gene Delivery in Chlamydomonas reinhardtii

open access: yesBiotechnology and Bioengineering, Volume 122, Issue 8, Page 2218-2227, August 2025.
A novel strategy for nuclear gene delivery in microalgae using a cell‐penetrating peptide (CPP) and nuclear localization signal (NLS) is described. The authors developed a triple nanocomplex of CPP, plasmid DNA, and SV40 NLS to enhance nuclear delivery in Chlamydomonas reinhardtii.
Eun Jeong Sim   +10 more
wiley   +1 more source

PI3K/AKT/mTOR Axis in Cancer: From Pathogenesis to Treatment

open access: yesMedComm, Volume 6, Issue 8, August 2025.
The PI3K/AKT/mTOR signaling axis is crucial in cancer progression, regulating cell growth, survival, and metabolism. Often hyperactivated through mutations or loss of tumor suppressors such as PTEN, this pathway promotes cancer cell proliferation and survival by inhibiting apoptosis and activating mTOR, which drives protein synthesis and suppresses ...
Mingyang Jiang   +10 more
wiley   +1 more source

Astrocyte in Neurological Disease: Pathogenesis and Therapy

open access: yesMedComm, Volume 6, Issue 8, August 2025.
This review provides comprehensive overview of astrocytes in neurological disorders. Astrocytes contribute to neurological disorders via A1/A2 polarization, inducing neuroinflammation, synaptic, and BBB dysfunction. Metabolic disturbances in glucose, lipid, and amino acid pathways leading to oxidative stress and mitochondrial damage.
Meihui Huang   +4 more
wiley   +1 more source

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