Results 171 to 180 of about 30,834 (284)

Inhibition Effects of Patchouli Alcohol, Carvacrol, p‐Cymene, Eucalyptol and Their Formulations Against Influenza Virus Pneumonia Through TLR4/NF‐κB/NLRP3 Signaling Pathway

open access: yesChemical Biology &Drug Design, Volume 106, Issue 2, August 2025.
The study provides an experimental basis for volatile monomers of aromatic herbs to be formulated for the treatment of influenza virus pneumonia. The overall scope of the study is shown in the image. ABSTRACT As a kind of drug mostly used historically to treat epidemics, aromatic botanicals have volatile oils as active components.
Ruilin Lv   +9 more
wiley   +1 more source

Kapβ2 Reverses Sevoflurane‐Induced Hydrogel Phase Transition of hnRNPA2/B1‐SG in Hypoxic Primary Rat Hippocampal Neurons

open access: yesCNS Neuroscience &Therapeutics, Volume 31, Issue 8, August 2025.
Sevoflurane exacerbates hippocampal neuronal dysfunction under hypoxic conditions by inducing the cytoplasmic mislocalization of hnRNPA2/B1, which drives abnormal liquid–liquid phase separation (LLPS) and subsequent irreversible hydrogel transition of hnRNPA2/B1‐containing stress granules (SGs).
Miao Zhang   +8 more
wiley   +1 more source

The Application of Polymeric Nanoparticles as Drug Delivery Carriers to Cells in Neurodegenerative Diseases

open access: yesCell Proliferation, Volume 58, Issue 8, August 2025.
Polymeric nanoparticles represent promising drug (gene) delivery carriers to the brain due to their unique advantages to facilitate the penetration of blood–brain barrier and endocytosis of neuronal cells in neurodegenerative diseases. ABSTRACT In spite of great advances in modern medicine, there are a few effective strategies for the treatment of ...
Lian Jin   +4 more
wiley   +1 more source

The quest for the best target genes for RNAi‐mediated pest control

open access: yesInsect Molecular Biology, Volume 34, Issue 4, Page 505-517, August 2025.
A major challenge for RNAi mediated pest control is the identification of the most effective RNAi target genes from the pool of ~37% of all genes that are essential. Effective RNAi target genes are predominantly highly conserved genes serving basic cellular functions such as protein degradation.
Doga Cedden, Gregor Bucher
wiley   +1 more source

Large-scale purifications reveal yeast and human stress granule cores are heterogeneous particles with complex transcriptomes and proteomes

open access: yesCell Reports
Summary: Stress granules are a conserved response of eukaryotic cells to environmental insults. These cytoplasmic ribonucleoprotein condensates have hitherto been primarily studied by microscopy, which showed previously that they comprise dense ∼200 nm ...
Natalia A. Demeshkina   +1 more
doaj  

Exploring Therapeutic Targets From Spreading Patterns Against Respiratory Syncytial Virus

open access: yesThe FASEB Journal, Volume 39, Issue 14, 31 July 2025.
RSV spreads through three main modes of infection: receptor‐dependent infection of free viral particles, syncytia formation, and transmission via actin filaments. CX3CR1, CCR3, and HSPG mediate viral adsorption; the IGF1R signaling pathway facilitates viral internalization by recruiting NCL to the membrane surface, and the RHO GTPase and PI3K signaling
Han Zhang   +3 more
wiley   +1 more source

Home - About - Disclaimer - Privacy