Results 191 to 200 of about 33,782 (294)

MSC‐Derived Exosomal lnc‐AGT‐3: A Novel Anti‐Angiogenic Target in Age‐Related Macular Degeneration Through p53 Signaling Pathway

open access: yesAging Cell, Volume 25, Issue 2, February 2026.
MSC‐derived exosomes deliver lnc‐AGT‐3 to vascular endothelial cells, where it binds hnRNP K in the nucleus. This interaction inhibits p53 ubiquitination, enhancing p53 stabilization and transcriptional activation of anti‐angiogenic targets TSP1. Consequently, p53‐mediated signaling is potentiated, effectively suppressing choroidal neovascularization ...
Lingjie Kong   +9 more
wiley   +1 more source

SYNCAS‐mediated CRISPR‐Cas9 genome editing in the Jewel wasp, Nasonia vitripennis

open access: yesInsect Molecular Biology, Volume 35, Issue 1, Page 48-55, February 2026.
Maternal injection of Cas9 RNP together with BAPC and saponins (SYNCAS) results in efficient gene editing of Nasonia vitripennis offspring. The timing of injection and egg collection is important for maximising efficiency and reducing screening effort.
Filippo Guerra   +2 more
wiley   +1 more source

Mining Potential Therapeutic Targets for T Cell Exhaustion in Osteoarthritis by Integrating Mendelian Randomization and Single‐Cell Sequencing

open access: yesThe FASEB Journal, Volume 40, Issue 2, 31 January 2026.
This study conducted an integrated analysis using multi‐source data, with specific data sources including the GEO database (encompassing datasets GSE55235, GSE55457, and GSE152805), literature‐mined gene sets, and the IEU OpenGWAS database (dataset ebi‐a‐GCST005814).
Jiahong Li   +9 more
wiley   +1 more source

Comparative Analysis of Extracellular Vesicle Isolation From Equine Serum and Plasma Using Two Isolation Methods With Structural and Proteomic Validation

open access: yesThe FASEB Journal, Volume 40, Issue 2, 31 January 2026.
Schematic workflow of plasma‐ and serum‐derived extracellular vesicle (EV) analysis in horses, including sample preparation, EV isolation using size‐exclusion chromatography (SEC) and ultracentrifugation (UC), vesicle characterization by nanoparticle tracking analysis (NTA) and transmission electron microscopy (TEM), and comparative proteomic profiling
Dominika Milczek‐Haduch   +5 more
wiley   +1 more source

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