A Discrete 3′ Region of U6 Small Nuclear RNA Modulates the Phosphorylation Cycle of the C1 Heterogeneous Nuclear Ribonucleoprotein Particle Protein† [PDF]
, 1996 Sandra H. Mayrand +2 more
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DOTAP-Based Hybrid Nanostructured Lipid Carriers for CRISPR-Cas9 RNP Delivery Targeting <i>TGFB1</i> in Diabetic Nephropathy. [PDF]
PharmaceuticsJummah N +6 more
europepmc +1 more source
Targeting the Spliceosomal Protein USP39 Through Allosteric Ligands and PROTAC‐Induced Degradation
Angewandte Chemie International Edition, Volume 65, Issue 5, 28 January 2026.Proteolysis‐targeting chimeras (PROTACs) enable degradation of proteins previously considered undruggable by harnessing the cellular ubiquitin–proteasome system. In this study, Schäfer et al. identify thiazole‐based small molecules that allosterically bind the zinc finger domain of ubiquitin‐specific protease 39 (USP39), a non‐enzymatic scaffold ...
Daniel Schäfer +11 more
wiley +1 more source
An improved CRISPR-Cas9 protein-based method for knocking out insect Sf9 cell genes. [PDF]
Appl Microbiol BiotechnolGraça M +4 more
europepmc +1 more source
Modeling large RNAs and ribonucleoprotein particles using molecular mechanics techniques
, 1994 Arun Malhotra +2 more
openalex +1 more source
Human Ro ribonucleoprotein particles: characterization of native structure and stable association with the La polypeptide. [PDF]
, 1990 Gilles Boire, Joseph Craft
openalex +1 more source
Functional and structural impact of target uridine substitutions on the H/ACA ribonucleoprotein particle pseudouridine synthase. [PDF]
Biochemistry, 2010 Zhou J, Liang B, Liang B, Li H.
europepmc +1 more source
Enhanced Cellular Uptake of Compact Cas Proteins: A Comparative Study of Cas12f and Cas9 in Human Cells. [PDF]
Eng Life SciShalaby KE +5 more
europepmc +1 more source