Results 21 to 30 of about 30,834 (284)

Requirement of heterogeneous nuclear ribonucleoprotein C for BRCA gene expression and homologous recombination.

PLoS ONE, 2013
BackgroundHeterogeneous nuclear ribonucleoprotein C1/C2 (hnRNP C) is a core component of 40S ribonucleoprotein particles that bind pre-mRNAs and influence their processing, stability and export. Breast cancer tumor suppressors BRCA1, BRCA2 and PALB2 form
Rachel W Anantha, Allen L Alcivar, Jianglin Ma, Hong Cai, Srilatha Simhadri, Jernej Ule, Julian König, Bing Xia   +7 more
doaj   +1 more source

Packaging and Uncoating of CRISPR/Cas Ribonucleoproteins for Efficient Gene Editing with Viral and Non-Viral Extracellular Nanoparticles

Viruses, 2023
Rapid progress in gene editing based on clustered regularly interspaced short palindromic repeats/CRISPR-associated protein (CRISPR/Cas) has revolutionized functional genomic studies and genetic disease correction.
Dmitriy Mazurov, Lama Ramadan, Natalia Kruglova   +2 more
doaj   +1 more source

Assembly of the 68- and 72-kD Proteins of Signal Recognition Particle with 7S RNA [PDF]

, 1993
Signal recognition particle (SRP), the cytoplasmic ribonucleoprotein particle that mediates the targeting of proteins to the ER, consists of a 7S RNA and six different proteins. The 68- (SRP68) and 72-(SRP72) kD proteins of SRP are bound to the 7S RNA of
Ashford, Anthony J., Dobberstein, Bernhard, Frank, Rainer, Lütcke, Henrich, Prehn, Siegfried, Remus, Michael   +5 more
core   +1 more source

The TROVE module: A common element in Telomerase, Ro and Vault ribonucleoproteins

BMC Bioinformatics, 2003
Background Ribonucleoproteins carry out a variety of important tasks in the cell. In this study we show that a number of these contain a novel module, that we speculate mediates RNA-binding. Results The TROVE module – Telomerase, Ro and Vault module – is
Bateman Alex, Kickhoefer Valerie
doaj   +1 more source

Signal Recognition Particle in Human Diseases

Frontiers in Genetics, 2022
The signal recognition particle (SRP) is a ribonucleoprotein complex with dual functions. It co-translationally targets proteins with a signal sequence to the endoplasmic reticulum (ER) and protects their mRNA from degradation.
Morgana K. Kellogg, Elena B. Tikhonova, Andrey L. Karamyshev   +2 more
doaj   +1 more source

Assessment of Vault Particles in Cancer Cell Line-Derived Extracellular Vesicle Preparations. [PDF]

J Extracell Vesicles
ABSTRACT Extracellular vesicles (EVs) may contain a variety of molecular cargo, including proteins and nucleic acids. Vault particle components have been repeatedly reported in the literature as EV cargo. Here, we demonstrated that vault RNA (vtRNA) and major vault protein (MVP) were highly abundant in EV pellets enriched by differential centrifugation
Liu X, Nizamudeen ZA, Hill CJ, Parmenter C, Arkill KP, Lambert DW, Hunt S.   +6 more
europepmc   +2 more sources

Functionality of in vitro reconstituted group II intron RmInt1-derived ribonucleoprotein particles

Frontiers in Molecular Biosciences, 2016
The functional unit of mobile group II introns is a ribonucleoprotein particle (RNP) consisting of the intron-encoded protein (IEP) and the excised intron RNA. The IEP has reverse transcriptase activity but also promotes RNA splicing, and the RNA-protein
María Dolores Molina-Sánchez, Fernando Manuel García-Rodríguez, Nicolas Toro   +2 more
doaj   +1 more source

Functional insights from a surface antigen mRNA-bound proteome

eLife, 2021
Trypanosoma brucei is the causative agent of human sleeping sickness. The parasites’ variant surface glycoprotein (VSG) enables them to evade adaptive immunity via antigenic variation. VSG comprises 10% of total cell protein and the high stability of VSG
Larissa Melo do Nascimento, Franziska Egler, Katharina Arnold, Nina Papavasiliou, Christine Clayton, Esteban Erben   +5 more
doaj   +1 more source

The synthesis of hemoglobin in a cell-free system [PDF]

, 1958
The microsomal particles (1) have been implicated as the major sites of protein synthesis within the cells of a variety of tissues. The studies of Borsook, Zamecnik, Hultin, and others, with intact animals and various types of whole cell systems (see ...
Allen, Esther, Lamfrom, Hildegarde, Schweet, Richard   +2 more
core   +2 more sources

Measles Virus Ribonucleoprotein Complexes Rapidly Spread across Well-Differentiated Primary Human Airway Epithelial Cells along F-Actin Rings

mBio, 2019
Measles virus (MeV) is a highly contagious human pathogen that continues to be a worldwide health burden. One of the challenges for the study of MeV spread is the identification of model systems that accurately reflect how MeV behaves in humans.
Brajesh K. Singh, Christian K. Pfaller, Roberto Cattaneo, Patrick L. Sinn   +3 more
doaj   +1 more source