Results 41 to 50 of about 33,782 (294)

Structures of the signal recognition particle receptor from the archaeon Pyrococcus furiosus: implications for the targeting step at the membrane. [PDF]

PLoS ONE, 2008
In all organisms, a ribonucleoprotein called the signal recognition particle (SRP) and its receptor (SR) target nascent proteins from the ribosome to the translocon for secretion or membrane insertion.
Pascal F Egea, Hiro Tsuruta, Gladys P de Leon, Johanna Napetschnig, Peter Walter, Robert M Stroud   +5 more
doaj   +1 more source

Potent programmable antiviral against dengue virus in primary human cells by Cas13b RNP with short spacer and delivery by VLP

Molecular Therapy: Methods & Clinical Development, 2021
With sequencing as a standard frontline protocol to identify emerging viruses such Zika virus and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), direct utilization of sequence data to program antivirals against the viruses could accelerate
Ekapot Singsuksawat, Suppachoke Onnome, Pratsaneeyaporn Posiri, Amporn Suphatrakul, Nittaya Srisuk, Rapirat Nantachokchawapan, Hansa Praneechit, Chutimon Sae-kow, Pala Chidpratum, Khanit Sa-ngiamsuntorn, Suradej Hongeng, Panisadee Avirutnan, Thaneeya Duangchinda, Bunpote Siridechadilok   +13 more
doaj   +1 more source

Cell division promotes efficient retrotransposition in a stable L1 reporter cell line [PDF]

, 2013
Background: Long interspersed element type one (L1) actively modifies the human genome by inserting new copies of itself. This process, termed retrotransposition, requires the formation of an L1 ribonucleoprotein (RNP) complex, which must enter the ...
An, Wenfeng, Ivics, Zoltán, Izsvák, Zsuzsanna, Martin, Sandra L., Mátés, Lajos, Xie, Yi   +5 more
core   +2 more sources

Characterization of LINE-1 Ribonucleoprotein Particles

PLoS Genetics, 2010
The average human genome contains a small cohort of active L1 retrotransposons that encode two proteins (ORF1p and ORF2p) required for their mobility (i.e., retrotransposition). Prior studies demonstrated that human ORF1p, L1 RNA, and an ORF2p-encoded reverse transcriptase activity are present in ribonucleoprotein (RNP) complexes.
Aurélien J Doucet, Amy E Hulme, Elodie Sahinovic, Deanna A Kulpa, John B Moldovan, Huira C Kopera, Jyoti N Athanikar, Manel Hasnaoui, Alain Bucheton, John V Moran, Nicolas Gilbert   +10 more
openaire   +4 more sources

Ratcheted transport and sequential assembly of the yeast telomerase RNP

Cell Reports, 2023
Summary: The telomerase ribonucleoprotein particle (RNP) replenishes telomeric DNA and minimally requires an RNA component and a catalytic protein subunit.
Hannah Neumann, Louise Bartle, Erin Bonnell, Raymund J. Wellinger   +3 more
doaj   +1 more source

A Distinct Mechanism to Achieve Efficient Signal Recognition Particle (SRP)-SRP Receptor Interaction by the Chloroplast SRP Pathway [PDF]

, 2009
Cotranslational protein targeting by the signal recognition particle (SRP) requires the SRP RNA, which accelerates the interaction between the SRP and SRP receptor 200-fold.
Jaru-Ampornpan, Peera, Nguyen, Thang X., Shan, Shu-ou   +2 more
core   +2 more sources

Renal Manifestation of Mixed Connective Tissue Disease

Journal of the Scientific Society
A young female presented with facial puffiness and swelling in both lower limbs for 3 months, distension of the abdomen, and breathlessness on exertion for 1 month with a history of hypertension and hypothyroid on regular treatment.
Shalini Ashok, Meenakshi Kalyan, Vamsavardhan Reddy, S. Sumangala   +3 more
doaj   +1 more source

Fibrillarin-GFP Facilitates the Identification of Meiotic Competent Oocytes

Frontiers in Cell and Developmental Biology, 2021
The nucleolus undergoes significant functional changes and plays important roles during mammalian oocyte meiotic maturation. Fibrillarin (FBL) is the component of nucleolar small nuclear ribonucleoprotein (snRNP) particle and localizes to the dense ...
Ting Wang, Ting Wang, Jie Na
doaj   +1 more source

Structural basis for dual roles of Aar2p in U5 snRNP assembly [PDF]

, 2013
Yeast U5 small nuclear ribonucleoprotein particle (snRNP) is assembled via a cytoplasmic precursor that contains the U5-specific Prp8 protein but lacks the U5-specific Brr2 helicase.
Beggs, J.D., Cristão, V.F., Heroven, A.C., Holton, N., Jovin, S.M., Lührmann, R., Santos, K.F., Wahl, M.C., Weber, G.   +8 more
core   +1 more source

Drug hypersensitivity caused by alteration of the MHC-presented self-peptide repertoire [PDF]

, 2012
Idiosyncratic adverse drug reactions are unpredictable, dose independent and potentially life threatening; this makes them a major factor contributing to the cost and uncertainty of drug development. Clinical data suggest that many such reactions involve
A. Lucas, A. M. English, A. Sette, A. Wriston, B. J. Grant, B. Peters, C. A. F. de Oliveira, C. Oseroff, Cahalan, Chessman, Chung, D. A. Ostrov, D. F. Hunt, Day, E. Phillips, Faletto, Friesner, H. M. Grey, H. Mei, Harndahl, J. Jakoncic, J. Shabanowitz, J. Sidney, Ko, L. Shi, L. Yang, Lavergne, M. Harndahl, Mallal, Martin, Melroy, Phillips, Pichler, Rudolph, S. Buus, S. Lu, S. Mallal, S. Southwood, Shastri, Shimizu, Sidney, Sidney, Tenzer, Udeshi, Y. A. Pompeu, Yang, Yang, Yewdell   +47 more
core   +4 more sources