Results 71 to 80 of about 30,834 (284)

Histone Demethylase UTX Suppresses Tumor Cell Proliferation by Regulating Stress Granules

Advanced Science, EarlyView.
These findings indicate that cytoplasmic UTX forms puncta and co‐localizes in stress granules (SGs) upon various stresses. UTX TPR‐domain‐dependently and demethylase‐activity‐independently destabilize SGs by binding G3BP1, the SG hub protein, to disrupt SG network, thus affects tumorigenesis.
Xikai Liu, Xinran Liu, Mei Xue, Yushuo Xiao, Yuchen Chen, Rong Qiu, Di Wu, Yihao Zhou, Jiao Wang, Yan Yuan, Linwei Yu, Tianyi Shi, Yangkai Li, Hua Su, Hong Chen, Yong Liu, Kun Huang, Ling Zheng   +17 more
wiley   +1 more source

Putting a Kink in HIV-1 Particle Infectivity: Rocaglamide Inhibits HIV-1 Replication by Altering Gag-Genomic RNA Interaction

Viruses
Our examination of RNA helicases for effects on HIV-1 protein production and particle assembly identified Rocaglamide (RocA), a known modulator of eIF4A1 function, as an inhibitor of HIV-1 replication in primary CD4+ T cells and three cell systems. HIV-1
Paul Rosenfeld, Gatikrushna Singh, Amanda Paz Herrera, Juan Ji, Bradley Seufzer, Xiao Heng, Kathleen Boris-Lawrie, Alan Cochrane   +7 more
doaj   +1 more source

Identification of HNRNPK as regulator of hepatitis C virus particle production.

PLoS Pathogens, 2015
Hepatitis C virus (HCV) is a major cause of chronic liver disease affecting around 130 million people worldwide. While great progress has been made to define the principle steps of the viral life cycle, detailed knowledge how HCV interacts with its host ...
Marion Poenisch, Philippe Metz, Hagen Blankenburg, Alessia Ruggieri, Ji-Young Lee, Daniel Rupp, Ilka Rebhan, Kathrin Diederich, Lars Kaderali, Francisco S Domingues, Mario Albrecht, Volker Lohmann, Holger Erfle, Ralf Bartenschlager   +13 more
doaj   +1 more source

N6-methyladenosine (m6A) RNA methylation regulator SNRPC is a prognostic biomarker and is correlated with immunotherapy in hepatocellular carcinoma

World Journal of Surgical Oncology, 2021
Background Hepatocellular carcinoma (HCC) is one of the most common malignancies in the world, and due to its complex pathogenic factors, its prognosis is poor.
Jihao Cai, Minglei Zhou, Jianxin Xu
doaj   +1 more source

Packaging signals in single-stranded RNA viruses: nature’s alternative to a purely electrostatic assembly mechanism [PDF]

, 2013
The formation of a protective protein container is an essential step in the life-cycle of most viruses. In the case of single-stranded (ss)RNA viruses, this step occurs in parallel with genome packaging in a co-assembly process.
Bakker, S.E., Barker, A.M., Borodavka, A., Dykeman, Eric, Ford, R.J., Pearson, A.R., Phillips, S.E.V., Ranson, N.A., Stockley, P.G., Tuma, R., Twarock, R.   +10 more
core   +2 more sources

Small Extracellular Vesicles Orchestrate Cisplatin‐Induced Ototoxicity: Potential Biomarker and Targets Discovery

Advanced Science, EarlyView.
Cisplatin causes reactive oxygen species accumulation, leading to apoptosis and inflammation in cochlear hair cells. Small extracellular vesicles primarily derived from the damaged hair cells likely contribute to cisplatin‐induced ototoxicity, carrying a variety of microRNAs and proteins.
Jingru Ai, Shasha Zhang, Mingchen Dai, Pei Jiang, Jingyuan Huang, Hairong Xiao, Yanqin Lin, Xujun Tang, Wei Tong, Jun He, Qiuyue Mao, Yintao Wang, Zixuan Ye, Tian Wang, Renjie Chai   +14 more
wiley   +1 more source

R2TP/PAQosome as a promising chemotherapeutic target in cancer

Japanese Dental Science Review, 2020
R2TP/PAQosome (particle for arrangement of quaternary structure) is a novel multisubunit chaperone specialized in the assembly/maturation of protein complexes that are involved in essential cellular processes such as PIKKs (phosphatidylinositol 3-kinase ...
Yoshito Kakihara, Tetsuo Kiguchi, Atsushi Ohazama, Makio Saeki   +3 more
doaj  

Splicing Shift of RAC1 Accelerates Tumorigenesis and Defines a Potent Therapeutic Target in Lung Cancer

Advanced Science, EarlyView.
Dysregulated RNA splicing is an underappreciated molecular feature of cancer. By integrating murine and cellular models with patient specimens of lung adenocarcinoma, this study demonstrates that RAC1B, rather than RAC1A isoform, promotes tumorigenesis and presents a potent therapeutic target for lung cancer. Mechanistically, RAC1B preferentially binds
Yueren Yan, Ning Wang, Bowen Xing, Min Yang, Jun Shang, Yufang Bao, Lixing Xiao, Ningxia Zhang, Yunpeng Ren, Chunnan Liu, Yuting Chen, Han Han, Yunjian Pan, Lei Lv, Wei‐Xing Zong, Hongbin Ji, Changyou Zhan, Zefeng Wang, Haiquan Chen, Yongbo Wang   +19 more
wiley   +1 more source

Crystal Structure of Prp5p Reveals Interdomain Interactions that Impact Spliceosome Assembly

Cell Reports, 2013
The DEAD-box adenosine triphosphatase (ATPase) Prp5p facilitates U2 small nuclear ribonucleoprotein particle (snRNP) binding to the intron branch site region during spliceosome assembly. We present crystal structures of S.
Zhi-Min Zhang, Fei Yang, Jinru Zhang, Qing Tang, Jie Li, Jing Gu, Jiahai Zhou, Yong-Zhen Xu   +7 more
doaj   +1 more source

Transient tether between the SRP RNA and SRP receptor ensures efficient cargo delivery during cotranslational protein targeting [PDF]

, 2010
Kinetic control of macromolecular interactions plays key roles in biological regulation. An example of such control occurs in cotranslational protein targeting by the signal recognition particle (SRP), during which the SRP RNA and the cargo both ...
Shan, Shu-ou, Shen, Kuang
core   +3 more sources