Results 81 to 90 of about 30,834 (284)

The NSP5, ORF6 and NSP13 of SARS‐CoV‐2 Cooperate to Modulate Inflammatory Cell Death Activation

Advanced Science, EarlyView.
ZBP1 is capable of initiating a large cell death complex to induce programmed cell death during SARS‐CoV‐2 infection. However, SARS‐CoV‐2 can inhibit the activation of ZBP1‐mediated cell death by targeting key components of this complex. This suppression of ZBP1‐mediated cell death may account for the increased mortality observed in patients co ...
Huan Wang, Mengdi Liang, Jing Zhang, Hua Tong, Fenfen Zhang, Ying Liu, Pui Wang, Mengmeng Chang, Fei Han, Siwen Liu, Yongping Lin, Wenjun Song, Rajendra Karki, Peihui Wang, Honglin Chen, Yang Liu, Min Zheng   +16 more
wiley   +1 more source

Mud2 functions in transcription by recruiting the Prp19 and TREX complexes to transcribed genes [PDF]

, 2018
The different steps of gene expression are intimately linked to coordinate and regulate this complex process. During transcription, numerous RNA-binding proteins are already loaded onto the nascent mRNA and package the mRNA into a messenger ...
Georgieva, Sofia, Hüttelmaier, Stefan, Kopytova, Daria, Minocha, Rashmi, Misiak, Danny, Popova, Varvara, Sträßer, Katja   +6 more
core   +1 more source

EFTUD2 Regulates Cortical Morphogenesis via Modulation of Caspase‐3 and Aifm1 Splicing Pathways

Advanced Science, EarlyView.
EFTUD2, a spliceosomal GTPase linked to MFDM, regulates cortical development through apoptotic control. Conditional Eftud2 knockout in murine neural stem cells induces microcephaly and cortical disorganization, while pathogenic variants drive neuronal loss.
Liping Chen, Ying Li, Yan Yu, Mingze Cai, Hao Li, Minghe Huang, Guochao Yang, Jiageng Guo, Huailin Wang, Zhihong Song, Wei Shen, Huihui Jiang, Haitao Wu   +12 more
wiley   +1 more source

Schlafen-5 inhibits LINE-1 retrotransposition

iScience, 2023
Summary: Long interspersed element 1 (LINE-1) is the only currently known active autonomous transposon in humans, and its retrotransposition may cause deleterious effects on the structure and function of host cell genomes and result in sporadic genetic ...
Jiwei Ding, Shujie Wang, Qipeng Liu, Yuqing Duan, Tingting Cheng, Zhongjie Ye, Zhanding Cui, Ao Zhang, Qiuyu Liu, Zixiong Zhang, Ning Zhang, Qian Liu, Ni An, Jianyuan Zhao, Dongrong Yi, Quanjie Li, Jing Wang, Yongxin Zhang, Ling Ma, Saisai Guo, Jinhui Wang, Chen Liang, Jinming Zhou, Shan Cen, Xiaoyu Li   +24 more
doaj  

The 5S RNP Couples p53 Homeostasis to Ribosome Biogenesis and Nucleolar Stress

Cell Reports, 2013
Several proto-oncogenes and tumor suppressors regulate the production of ribosomes. Ribosome biogenesis is a major consumer of cellular energy, and defects result in p53 activation via repression of mouse double minute 2 (MDM2) homolog by the ribosomal ...
Katherine E. Sloan, Markus T. Bohnsack, Nicholas J. Watkins   +2 more
doaj   +1 more source

MOV10 RNA helicase is a potent inhibitor of retrotransposition in cells. [PDF]

PLoS Genetics, 2012
MOV10 protein, a putative RNA helicase and component of the RNA-induced silencing complex (RISC), inhibits retrovirus replication. We show that MOV10 also severely restricts human LINE1 (L1), Alu, and SVA retrotransposons.
John L Goodier, Ling E Cheung, Haig H Kazazian   +2 more
doaj   +1 more source

Defending the genome from the enemy within:mechanisms of retrotransposon suppression in the mouse germline [PDF]

, 2013
The viability of any species requires that the genome is kept stable as it is transmitted from generation to generation by the germ cells. One of the challenges to transgenerational genome stability is the potential mutagenic activity of transposable ...
A Aravin, A Dupressoir, A Dupressoir, A Dupressoir, A Fadloun, A Inagaki, A Inoue, A Inoue, A Meissner, A Prokhortchouk, A Puech, A Sookdeo, A Tsumura, A Vourekas, AA Aravin, AA Aravin, AA Aravin, AA Zabolotneva, AE Peaston, AR Muotri, AR Muotri, B Hendrich, BH Schrans-Stassen, C Chen, C Lu, C Popp, C-X Song, C-X Song, CE Nestor, CG Lian, CM Davis, CP Walsh, D Bourc’his, D Bourc’his, D Branciforte, D Guallar, D Haig, D Lucifero, D Lucifero, D Reiss, D Ribet, D Ribet, D Ribet, D Sproul, D Wolf, D Wolf, DA Kramerov, DC Hancks, DJ Lees-Murdock, DM Maatouk, Donncha S. Dunican, DS Dunican, DT Ting, E Beyret, E Beyret, E Khazina, E Li, EB Chuong, EL Kuff, ES Lander, F Santos, F Yang, FD Araujo, G Hutvagner, G Velasco, GD Evrony, H Cedar, H Cedar, H Heyn, H Kano, H Khan, H Kobayashi, H Stroud, HJ Cooke, HM Rowe, HM Rowe, HM Rowe, I Cantone, I Martín Caballero, I Suetake, IA Maksakova, Ian R. Adams, J Borgel, J Brennecke, J Chen, J Gimenez, J Lange, J Reichmann, J Reichmann, J Rossant, J Sharif, J Xiol, J-H Ng, JA Hackett, JA Hackett, JA Yoder, James H. Crichton, JD Lewis, JK Baillie, JL Garcia-Perez, JL Goodier, JN Athanikar, JO Kriegs, JP Reddington, JP Reddington, JP Thomson, JP Thomson, JV Moran, K Dennis, K Hata, K Hayashi, K Hisada, K Kurimoto, K Myant, K Zheng, K Zheng, KP Koh, L Jackson-Grusby, L Ma, L Piko, L Shen, L-Q Sun, LK Hutnick, M Abe, M Chotalia, M Denne, M Dewannieux, M Dewannieux, M Dewannieux, M Freitag, M Kaneda, M Kaneda, M Ko, M Ko, M Leeb, M Okano, M Reuter, M Reuter, M Ruggiu, M Saitou, M Shoji, M Tachibana, M Tahiliani, M Weber, M Wiench, M Xu, MA Carmell, Marie MacLennan, MC Ward, MM Dawlaty, MM Dawlaty, MM Karimi, MT Romanish, N Bannert, N Gilbert, N Lane, N Mathioudakis, N Reynolds, N Yang, N Zamudio, OH Tam, P Hajkova, P Hajkova, PJ Skene, Q Feng, Q Yan, R Brunmeir, R Burdick, R Fuente De La, R Illingworth, R Lister, R Rebollo, R Shukla, R Yaman, R Öllinger, RH Waterston, Richard R. Meehan, RJ DeBerardinis, RJA Frost, RR Meehan, S Chuma, S Fazio De, S Guibert, S Ito, S Ito, S Kagiwada, S Kaufmann, S Kuntz, S Kuramochi-Miyagawa, S Kuramochi-Miyagawa, S Kuramochi-Miyagawa, S Kuramochi-Miyagawa, S Mi, S Milutinovic, S Salle La, S Schütt, S Seisenberger, S Solyom, S Takebayashi, S Yamaguchi, S-H Lee, SA Smallwood, SA Trelogan, SB Rothbart, SFC Soper, SK Mahadevaiah, SL Martin, SL Martin, SL Martin, SL Mathias, SP Sripathy, SS Tanaka, ST Grivna, T Matsui, T Singer, T Tanaka, T Watanabe, T Watanabe, T Watanabe, T-P Gu, TS Macfarlan, UM Galli, V Chapman, VV Vagin, W Deng, W Filipowicz, W Seifarth, W Wei, W Yan, WA Pastor, X Cai, X Nan, Y Kato, Y Seki, Y Tao, Y Unhavaithaya, Y Yabuta, Y Yotsuyanagi, Y-Q Su, Z Li, ZD Smith, ZD Smith   +241 more
core   +1 more source

Ribonucleoprotein particle appearing during sporulation in yeast [PDF]

Journal of Bacteriology, 1978
During sporulation of Saccharomyces cerevisiae, most strains accumulate an unmethylated 20S RNA. Contrary to previous reports, this sporulation 20S RNA is distinct from the short-lived methylated 20S RNA precursor of 18S rRNA. This RNA species was found in a cytoplasmic 32S ribonucleoprotein particle consisting of one single-stranded 20S RNA molecule ...
P J Wejksnora, James E. Haber
openaire   +3 more sources

Engineering Adenine Deaminase TadA for Precise and PAM‐Flexible Point Mutagenesis and Gradient‐Tuning Endogenous Protein Design

Advanced Science, EarlyView.
Base editing enables precise nucleotide substitutions but limited by bystander editing. This study engineers plant base editors by fusing optimized TadA variants with PAM‐flexible SpRY nickase, enabling A‐to‐G, C‐to‐T, and dual‐base conversions in a highly condensed window (≤3 nucleotides). Additionally, TadDBE (TadA Dual‐Base Editor)‐mediated directed
Kangli Sun, Si Cheng, Nan Chai, Jianing Mi, Ruixiang Zhang, Qian Qian, Zhiye Zheng, Ke Chen, Dongchang Zeng, Xin Peng, Mengyuan Shen, Degui Zhou, Qinlong Zhu, Qi Liu, Jiantao Tan   +14 more
wiley   +1 more source

Alternative Spliceosome Assembly Pathways Revealed by Single-Molecule Fluorescence Microscopy

Cell Reports, 2013
Removal of introns from nascent transcripts (pre-mRNAs) by the spliceosome is an essential step in eukaryotic gene expression. Previous studies have suggested that the earliest steps in spliceosome assembly in yeast are highly ordered and the stable ...
Inna Shcherbakova, Aaron A. Hoskins, Larry J. Friedman, Victor Serebrov, Ivan R. Corrêa, Jr., Ming-Qun Xu, Jeff Gelles, Melissa J. Moore   +7 more
doaj   +1 more source