Results 151 to 160 of about 22,188 (264)

A working model for cytoplasmic assembly of H/ACA snoRNPs. [PDF]

FEBS Lett
Angrisani A, Furia M.
europepmc   +1 more source

Genetic dissection reveals distinct contributions of the eS31 N‐terminal domain to translational accuracy in Saccharomyces cerevisiae

The FEBS Journal, EarlyView.
The eukaryote‐specific N‐terminal domain (NTD) of eS31 uses two distinct strategies to maintain translation fidelity. During elongation, a positively charged “hotspot” fine‐tunes the selection of incoming aa‐tRNA. During termination, the entire NTD acts as a structural scaffold to ensure the correct positioning of the release factor eRF1.
Qingxuan Gao, Hiroshi Otsuka, Kei Endo, Koichi Ito   +3 more
wiley   +1 more source

A Cryoprotectant-Compatible Nanoporous Platform for Stable and Scalable Delivery of Biopharmaceuticals. [PDF]

Adv Mater
Lee S, Kim S, Chong J, Kim MG, Lim K, Lee NE, Koo J, Kang J, Lee H.   +8 more
europepmc   +1 more source

Spatially resolved mapping of histones reveals selective neuronal response in Rett syndrome

The FEBS Journal, EarlyView.
Loss of Mecp2 function is associated with Rett syndrome (RTT). MeCP2 regulates chromatin, yet its influence on histone composition and dynamics is unclear. Combining MALDI‐MSI with LCM–LC–MS/MS, we mapped histone proteoforms across the dentate gyrus, cornu ammonis, and cerebellum in two mouse models of RTT.
Frederike Schäfer, Giuseppina De Rocco, Moritz Völker‐Albert, Ignasi Forne, Nicoletta Landsberger, Axel Imhof, Shibojyoti Lahiri   +6 more
wiley   +1 more source

Protocol for enhancing CRISPR-Cas9 genome editing using histone deacetylase inhibition and engineered virus-like particle delivery. [PDF]

STAR Protoc
Djamshidi M, Tanida R, Heshmatzad K, Krowicki H, Hill A, Yang Y, Riabowol K.   +6 more
europepmc   +1 more source

Unraveling in vitro phase separation and aggregation properties of the structured region of FMRP and the impact of Fragile X syndrome‐linked mutations

The FEBS Journal, EarlyView.
Fragile X messenger ribonucleoprotein 1 (FMRP) is a multidomain RNA‐binding protein associated with Fragile X Syndrome (FXS). We found that its N‐terminal structured region has an intrinsic propensity to undergo liquid–liquid phase separation and fibril formation. FXS‐associated mutations perturb protein stability and aggregation propensity, suggesting
Flavia Catalano, Alessandra Bigi, Francesca Troilo, Federica Gabriele, Gianluca Pistoia, Italia A. Asteriti, Francesco Angelucci, Giorgio Giardina, Fabrizio Chiti, Carlo Travaglini‐Allocatelli, Adele Di Matteo   +10 more
wiley   +1 more source

Nanocarrier-mediated CRISPR-Cas delivery: a novel approach against antibiotic-resistant superbugs. [PDF]

Saudi Pharm J
Almufarriji FM.
europepmc   +1 more source

Reactive oxygen species, antioxidants and the regulation of plant development

The FEBS Journal, EarlyView.
The regulation of axillary bud outgrowth by the interplay between phytohormone and redox signals. Axillary bud outgrowth is regulated by cellular energy status and the balance between phytohormones, notably abscisic acid (ABA) and gibberellic acid (GA).
Juwita R. Dewi, Christine H. Foyer, Michael J. Considine   +2 more
wiley   +1 more source

RNA origin of sex-biased immunity. [PDF]

Mol Ther Nucleic Acids
Chang HY, Chung L, Davis MM, Fiorentino D, Lee J, Lundberg E, Utz PJ.   +6 more
europepmc   +1 more source

Gene Editing for Haemophilia—The Next Frontier

Haemophilia, EarlyView.
ABSTRACT The recently approved haemophilia A and B gene therapies via adeno‐associated virus (AAV) showed a promising therapeutic response after a single injection, but there are still limitations, including the potential loss of transgene expression and restriction in adults.
Mirko Pinotti, Gregory A. Newby, Sundar Selvaraj, Steven W. Pipe   +3 more
wiley   +1 more source