Results 181 to 190 of about 25,962 (290)

HS‐AFM Reveals Hierarchical RNA Folding Driving Condensate Assembly and Material States

Small, EarlyView.
High‐speed atomic force microscopy reveals the nanoscale pathway of RNA condensate formation, from individual RNA folding to higher‐order assembly. Quantitative analyses of fusion dynamics and nanomechanical properties distinguish liquid‐like poly A condensates from solid‐like total RNA assemblies, providing a direct link between RNA self‐assembly and ...
S. M. Neaz Mahmud, Kenichi Umeda, Tamoghna Das, Nadia Shoukat, Noriyuki Kodera, Hanae Sato   +5 more
wiley   +1 more source

Hierarchical Nuclear Architecture in Pre-mRNA Splicing: From IDRs to Speckles and Meshworks. [PDF]

Int J Mol Sci
Masuda A, Matsuki T, Okamoto T, Inamura N, Fukada M, Kawaguchi Y.   +5 more
europepmc   +1 more source

Initial Review of Government‐Funded Reproductive Carrier Screening for Cystic Fibrosis, Spinal Muscular Atrophy and Fragile X Syndrome

Prenatal Diagnosis, EarlyView.
Paul A. Scuffham, Edwin P. Kirk, Martin B. Delatycki, Martin Downes, Nigel G. Laing   +4 more
wiley   +1 more source

Nanomedicine applications in lymphoma: Advancing precision diagnostics, targeted therapeutics, and prospective developments

VIEW, EarlyView.
Lymphoma is a group of blood cancers that can appear in lymph nodes, blood, bone marrow, spleen, liver, or the central nervous system, which makes drug delivery and disease monitoring difficult. This review summarizes how nanomedicine technologies may improve targeted treatment and imaging, while carefully separating approved or guideline‐supported ...
Mohd Ahmar Rauf, Yara Mashal, Afeefa Rao, Nasar Ata, Arun K. Iyer, Farhan Shah   +5 more
wiley   +1 more source

FAST-CRISPR: Fusogenic Association and Secured Transfection of CRISPR/Cas9 Ribonucleoproteins Using Lipid-Silica Hybrid Nanoparticles for Therapeutic Genome Editing. [PDF]

Small
Kim M, Kim K, Lee J, Lee S, Choi S, Park SA, Jeong E, Choi SY, Park HH, Park TE, Kwon T, Myung K, Yoo J, Cho SW, Joo J.   +14 more
europepmc   +1 more source

Enhanced fish detection sensitivity in aquatic systems using environmental RNA

Methods in Ecology and Evolution, EarlyView.
Abstract Environmental RNA (eRNA) can potentially augment the biological monitoring ability of the established environmental DNA (eDNA) application in conservation. Despite faster degradation, environmental RNA could offer unique advantages: it may help reduce the legacy signal compared to eDNA, provide insights into physiological status through gene ...
Ana Ramón‐Laca, Ramón Gallego, Carmen Duque, José L. J. Ledesma, Ignacio Doadrio, Kim M. Parsons, Krista M. Nichols, Samantha Engster, Abigail Wells, Ana Riesgo   +9 more
wiley   +1 more source

Rapid and Highly Efficient CRISPR-Cas9 RNP Genome Editing in Primary ILC2s. [PDF]

Eur J Immunol
Candelotti AM, Garzillo G, Bartolini S, Di Censo C, Peruzzi G, Stabile H, Fionda C, Sciumè G, Pietropaolo G.   +8 more
europepmc   +1 more source

Functional assessment of inherited myeloid neoplasm‐associated SAMD9L germline variants via Monoallelic CRISPR modelling

British Journal of Haematology, EarlyView.
Summary While the majority of myeloid neoplasms are sporadic, the increasing application of germline genetic testing has led the World Health Organization to designate ‘Myeloid malignancies with germline predisposition’ as a distinct clinical entity, carrying major implications for clinical care and research.
Elena Vuelta, Alessandro Liquori, Matias Morín, Lucia Soletto, Miguel Ángel Marugal, Marta Santiago‐Balsera, Miguel Gallardo, Miguel Ángel Moreno‐Pelayo, José Cervera, Alejandra Sanjuan‐Pla   +9 more
wiley   +1 more source

Transgene-free genome editing in citrus and poplar meristem tissues via biolistic ribonucleoprotein delivery of CRISPR-Cas9. [PDF]

Plant Cell Rep
Rocha DC, Omoregbee MO, Luo W, Fang H, Ye Q, Liu Y, Li G, Mascoveto J, de Souza AA, Coleman G, Culver JN, Qi Y.   +11 more
europepmc   +1 more source

Artificial intelligence–based 3D segmentation of tangle‐associated TDP‐43 in neurodegeneration

Brain Pathology, EarlyView.
Multiplex immunostaining of anti‐phosphorylated TDP‐43, tau (AT8, pS396, TauC3, MN423, GT38), and Thioflavin S combined with AI‐based object recognition, reconstruction, and TAT maturation analysis pipeline in limbic regions revealed that distinct aggregation and tangle maturation patterns underscored region‐specific dynamics in the neurodegenerative ...
Gokhan Uruk, Hossam Youssef, Rodolfo G. Gatto, Nadia Hossain, Jennifer L. Whitwell, Robert R. Reichard, Keith A. Josephs   +6 more
wiley   +1 more source