Results 291 to 300 of about 38,830 (350)

New Mechanisms and Therapeutic Targets in Systemic Lupus Erythematosus

MedComm, Volume 6, Issue 6, June 2025.
Systemic lupus erythematosus (SLE) is a multiple organ involved autoimmune disorder with heterogeneous clinical manifestations. Despite hallmark features such as elevated type I interferon and the production of numerous autoantibodies, the underlying pathogenic mechanisms remain elusive.
Jingru Tian, Hang Zhou, Wei Li, Xu Yao, Qianjin Lu   +4 more
wiley   +1 more source

Genes involved in metastasis in oral squamous cell carcinoma: A systematic review. [PDF]

Health Sci Rep
Mohtasham N, Zarepoor M, Shooshtari Z, Hesari KK, Mohajertehran F.   +4 more
europepmc   +1 more source

Phase Separation: A New Dimension to Understanding Tumor Biology and Therapy

MedComm – Oncology, Volume 4, Issue 2, June 2025.
Liquid–liquid phase separation (LLPS) facilitates the assembly of biomolecular condensates by leveraging weak multivalent interactions. The low‐complexity domains, foldable domains of proteins, and nucleic acids provide multivalent interaction sites among different molecules and contribute to the formation of condensates.
Xingwen Wang, Minqiao Lu, Yi Zhang, Jiangwen Ma, Ying Hu   +4 more
wiley   +1 more source

Oxidative Stress in Antigen Processing and Presentation

MedComm – Oncology, Volume 4, Issue 2, June 2025.
Reactive oxygen species (ROS) play a crucial role in antigen processing and presentation, essential for linking innate and adaptive immunity. While balanced ROS levels promote immune function, excess ROS can disrupt antigen recognition, resulting in immune dysfunction.
Qinxia Chang, Yaying Zhang, Xiaojun Liu, Peng Miao, Wenbing Pu, Shanshan Liu, Jing Zhang, Yuan Tian, Guobo Shen, Na Xie   +9 more
wiley   +1 more source

Characterization and functional analysis of chicken hnRNP protein. [PDF]

Poult Sci
Wang K, Huang M, Zeng Q, Wu H.
europepmc   +1 more source

Mitochondrial Ribosomal Protein Family in Cancers: Mechanistic Insights and Therapeutic Implications

MedComm – Oncology, Volume 4, Issue 2, June 2025.
Mitochondrial ribosomal proteins (MRPs) are the important components of mitoribosome. They are aberrantly expressed in various human cancers. In this review, we introduce the roles of MRPs in tumorigenesis and development by regulating OXPHOS and other mechanisms.
Qian Chen, Yingli Zhang, Jin‐Jian Lu, Ting Li   +3 more
wiley   +1 more source

Editorial: CNS myeloid cell function in health and disease. [PDF]

Front Immunol
Keller CW, Mundt S, Segal BM.
europepmc   +1 more source

CXXC5 is a ubiquitinated protein and is degraded by the ubiquitin‐proteasome pathway

Protein Science, Volume 34, Issue 6, June 2025.
Abstract CXXC5, as a member of the zinc‐finger CXXC family proteins, interacts with unmodified CpG dinucleotides to modulate the expression of genes involved in cellular proliferation, differentiation, and death in physiology and pathophysiology. Various signaling pathways, including mitogenic 17β‐estradiol (E2), contribute to the expression and ...
Hazal Ayten, Pelin Toker, Gizem Turan Duman, Çağla Ece Olgun, Öykü Deniz Demiralay, Büşra Bınarcı, Gizem Güpür, Pelin Yaşar, Hesna Begüm Akman, Per Haberkant, Mesut Muyan   +10 more
wiley   +1 more source

Chaperone dysfunction in motor neuron disease: new insights from studies of the SMN complex. [PDF]

Genetics
Matera AG.
europepmc   +1 more source

Target gene selection for sprayable dsRNA‐based biopesticide against Tetranychus urticae Koch (Acari: Tetranychidae)

Pest Management Science, Volume 81, Issue 6, Page 3055-3065, June 2025.
Silencing Prosbeta‐5 and Prosbeta‐1 resulted in high mortality in Tetranychus urticae, identifying them as potential target genes for double‐stranded RNA‐based biopesticides using spray‐induced gene silencing (SIGS). Abstract BACKGROUND Because of the excessive use of synthetic chemicals, the two‐spotted spider mite, Tetranychus urticae Koch, a highly ...
Yifei Wang, Yuanpeng Duan, Meibin Liu, Meifeng Ren, Yue Gao, Zhongfang Liu, Pengjiu Zhang, Lifei He, Renjun Fan, Xuguo Zhou, Jing Yang   +10 more
wiley   +1 more source