Results 271 to 280 of about 32,025 (309)

Partition Chromatography on Starch of Ribonucleosides

Nature, 1948
DURING work on ribonucleic acid turnover with nitrogen-15 in this Department, we found it necessary to isolate the different nitrogen-containing substances from small amounts of ribonucleic acid. It was thought that partition chromatography on starch as introduced by Elsden and Synge1 might give a possible solution to our problem. Vischer and Chargaff2
openaire   +3 more sources

Engineering Ribonucleoside Triphosphate Specificity in a Thymidylyltransferase

Biochemistry, 2008
Nature's glycosylation catalysts, glycosyltransferases, indirectly manipulate and control many important biological processes by transferring sugar nucleotide donors onto acceptors. Challenging chemical synthesis impedes synthetic access to sugar nucleotides and limits the study of many glycosyltransferases.
Jakeman, David L, Young, Jessica L, Huestis, Malcolm P, Peltier, Pauline, Daniellou, Richard, Nugier-Chauvin, Caroline, Ferrières, Vincent   +6 more
openaire   +4 more sources

An analytical method for the separation of sugar-methylated ribonucleosides from base-methylated and nonmethylated ribonucleosides

Analytical Biochemistry, 1972
Abstract A paper chromatographic method for the separation of 2′- O -methylated ribonucleosides from nonmethylated and base-methylated ribonucleosides, using paper impregnated with ammonium borate and a butanol/borate developing solvent, is presented.
Adhid Al-Arif, Michael B. Sporn
openaire   +3 more sources

Evaluation of urinary ribonucleoside profiling for clinical biomarker discovery using constant neutral loss scanning liquid chromatography/tandem mass spectrometry.

Rapid Communications in Mass Spectrometry, 2011
The patterns and levels of urinary excreted ribonucleosides which reflect RNA turnover and metabolism in humans offer the potential for early detection of disease and monitoring of therapeutic intervention.
F. Teichert, Swantje Winkler, H. Keun, W. Steward, A. Gescher, P. Farmer, Rajinder Singh   +6 more
semanticscholar   +1 more source

Interrogating the transcriptome with metabolically incorporated ribonucleosides

Molecular Omics, 2021
This review summarizes recent developments in metabolic labeling of RNA to study RNA synthesis and turnover, RNA binding proteins, and RNA modifications and modifying enzymes.
openaire   +3 more sources

Novel triazole ribonucleoside down-regulates heat shock protein 27 and induces potent anticancer activity on drug-resistant pancreatic cancer.

Journal of Medicinal Chemistry, 2009
A series of novel 3-arylethynyltriazolyl ribonucleosides were synthesized and assessed for their anticancer activity on the drug-resistant pancreatic cancer cell line MiaPaCa-2.
Yi Xia, Yang Liu, Jinqiao Wan, Menghua Wang, P. Rocchi, Fanqi Qu, J. Iovanna, Ling Peng   +7 more
semanticscholar   +1 more source

Ribonucleoside 2′,3′-orthocarbonates

J. Chem. Soc. D, 1969
Ribonucleosides undergo acid-catalysed exchange with tetramethyl orthocarbonate to give 2′,3′-O-dimethoxymethylidene derivatives.
G. R. Niaz, C. B. Reese
openaire   +2 more sources

Synthesis of novel C4-linked C2-imidazole ribonucleoside phosphoramidite and its application to probing the catalytic mechanism of a ribozyme.

Journal of Organic Chemistry, 2009
The synthesis of a novel C4-linked C2-imidazole ribonucleoside phosphoramidite (ICN-C2-PA 1) with a two-carbon linker between imidazole and ribose moieties is described.
Lisa Araki, Keiji Morita, Maho Yamaguchi, Zheng-yun Zhao, T. J. Wilson, D. Lilley, S. Harusawa   +6 more
semanticscholar   +1 more source

Repression of protein synthesis and mTOR signaling in rat liver mediated by the AMPK activator aminoimidazole carboxamide ribonucleoside.

American Journal of Physiology. Endocrinology and Metabolism, 2005
The studies described herein were designed to investigate the effects of 5-aminoimidazole-4-carboxamide-1-beta-D-ribonucleoside (AICAR), an activator of the AMP-activated protein kinase (AMPK), on the translational control of protein synthesis and ...
Ali K. Reiter, D. Bolster, Stephen Crozier, S. Kimball, L. Jefferson   +4 more
semanticscholar   +1 more source

STUDIES ON REACTION OF RIBONUCLEOSIDES WITH OXYPHOSPHORANE

Phosphorus, Sulfur, and Silicon and the Related Elements, 1996
Abstract Ester exchange reaction of ribonucleosides (2) with oxyphosphorane (1) afforded spirooxyphosphoranes (3). After hydrolysis followed by acetylation, the labile spirooxyphosphoranes such as 3a were converted into stable nucleotide derivatives (4). The possible mechanism for the conversion was also discussed.
Yufen Zhao, Xin Chen, Yuan Ma, Nan-Ding Zhang   +3 more
openaire   +2 more sources