Results 211 to 220 of about 9,338 (256)
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Biochemical Pharmacology, 1968
Abstract 6-Methylthiopurine ribonucleoside (MMPR) and several other adenosine analogues have important antitumor properties. These must be converted to the nucleotide by a purine ribonucleoside kinase in order to be biologically active. MMPR is converted to the nucleotide by an enzyme indistinguishable from adenosine kinase.
James K. Luce, D.H.W. Ho, Emil Frei
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Abstract 6-Methylthiopurine ribonucleoside (MMPR) and several other adenosine analogues have important antitumor properties. These must be converted to the nucleotide by a purine ribonucleoside kinase in order to be biologically active. MMPR is converted to the nucleotide by an enzyme indistinguishable from adenosine kinase.
James K. Luce, D.H.W. Ho, Emil Frei
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The metabolism of ribonucleoside by the human erythrocyte
Biochimica et Biophysica Acta (BBA) - General Subjects, 1968Abstract 1. 1. Metabolic intermediates were isolated from erythrocytes after incubation of fresh or stored human blood for 2 h at 37° with inosine, inosine plus adenine or with adenosine. 2. 2. The metabolism of inosine or adenosien by fresh erythrocytes led to a large increase in the concentration of fructose diphosphate and triose phosphate
Giovanni Bucolo, Grant R. Bartlett
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Reduction of Ribonucleosides to 2′‐Deoxyribonucleosides
Current Protocols in Nucleic Acid Chemistry, 2005AbstractRibonucleosides are converted into 2′‐deoxyribonucleosides in good yields by a four‐step procedure. Selective protection of the 3′‐ and 5′‐hydroxyl groups with 1,3‐dichloro‐1,1,3,3‐tetraisopropyl‐1,3‐disiloxane is followed by functionalization of the 2′‐hydroxyl group with phenoxythiocarbonyl chloride.
Stanislaw F. Wnuk, Morris J. Robins
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Structure of an imidazoline ribonucleoside
Acta Crystallographica Section C Crystal Structure Communications, 1988fl-D-Ribofuranosyl)-2-oxo-4-imidazoline-4- carboxylic acid dihydrate, C9H12N207.2H20 , Mr= 296.23, monoelinic, P21, a=9.3754(10), b= 5.0542 (4), c = 13.3075 (10) A, t= 103.155 (9) °, V = 614.03 (10) A), Z= 2, Dx= 1.602 gcm -a, Cu Ko., 2= 1.54178 A, /z = 12.175 cm-1; F(000) = 312, T= 295 K, R = 0.0311 for 2458 reflections (F > 4at).
Roland K. Robins +2 more
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Ribonucleoside triphosphatase in rabbit reticulocytes
Archives of Biochemistry and Biophysics, 1966Ribonucleoside triphosphatase in rabbit reticulocytes, discussing distribution in extracts, behavior in purification of amino acid and ...
I.D. Raacke, S. Matsushita, J. Fiala
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Synthesis of Azido and Triazolyl Purine Ribonucleosides
Current Protocols, 2021AbstractHere, we describe detailed synthetic protocols for preparation of 6‐amino/thio‐2‐triazolylpurine ribonucleosides. First, 9‐(2′,3′,5′‐tri‐O‐acetyl‐β‐D‐ribofuranosyl)‐2,6‐diazido‐9H‐purine, to be used as a key starting material, is synthesized in an SNAr reaction with NaN3 starting from commercially available 9‐(2′,3′,5′‐tri‐O‐acetyl‐β‐D ...
Dāgs Dāvis Līpiņš +4 more
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Canadian Journal of Biochemistry, 1965
Several aspects of the metabolism of inosine and uridine by Ehrlich ascites carcinoma cells in vitro have been found to be inhibited by ribonucleoside derivatives of four purine analogues. The synthesis of both inosine and uridine by intact tumor cells was profoundly inhibited in the presence of 6-methylmercaptopurine ribonucleoside.
A. R. P. Paterson, A. I. Simpson
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Several aspects of the metabolism of inosine and uridine by Ehrlich ascites carcinoma cells in vitro have been found to be inhibited by ribonucleoside derivatives of four purine analogues. The synthesis of both inosine and uridine by intact tumor cells was profoundly inhibited in the presence of 6-methylmercaptopurine ribonucleoside.
A. R. P. Paterson, A. I. Simpson
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Partition Chromatography on Starch of Ribonucleosides
Nature, 1948DURING work on ribonucleic acid turnover with nitrogen-15 in this Department, we found it necessary to isolate the different nitrogen-containing substances from small amounts of ribonucleic acid. It was thought that partition chromatography on starch as introduced by Elsden and Synge1 might give a possible solution to our problem. Vischer and Chargaff2
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Engineering Ribonucleoside Triphosphate Specificity in a Thymidylyltransferase
Biochemistry, 2008Nature's glycosylation catalysts, glycosyltransferases, indirectly manipulate and control many important biological processes by transferring sugar nucleotide donors onto acceptors. Challenging chemical synthesis impedes synthetic access to sugar nucleotides and limits the study of many glycosyltransferases.
Jakeman, David L +6 more
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Analytical Biochemistry, 1972
Abstract A paper chromatographic method for the separation of 2′- O -methylated ribonucleosides from nonmethylated and base-methylated ribonucleosides, using paper impregnated with ammonium borate and a butanol/borate developing solvent, is presented.
Adhid Al-Arif, Michael B. Sporn
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Abstract A paper chromatographic method for the separation of 2′- O -methylated ribonucleosides from nonmethylated and base-methylated ribonucleosides, using paper impregnated with ammonium borate and a butanol/borate developing solvent, is presented.
Adhid Al-Arif, Michael B. Sporn
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