Results 1 to 10 of about 77,265 (266)

TAS1553, a small molecule subunit interaction inhibitor of ribonucleotide reductase, exhibits antitumor activity by causing DNA replication stress [PDF]

Communications Biology, 2022
A small-molecule protein-protein interaction inhibitor of ribonucleotide reductase subunit, TAS1553, is shown to inhibit growth of both hematological and solid cancer xenograft tumors following oral administration in mice.
Hiroyuki Ueno, Takuya Hoshino, Wakako Yano, Sayaka Tsukioka, Takamasa Suzuki, Shoki Hara, Yoshio Ogino, Khoon Tee Chong, Tatsuya Suzuki, Shingo Tsuji, Hikaru Itadani, Ikuo Yamamiya, Yoshihiro Otsu, Satoshi Ito, Toshiya Yonekura, Miki Terasaka, Nozomu Tanaka, Seiji Miyahara   +17 more
doaj   +2 more sources

Clinical application and drug resistance mechanism of gemcitabine [PDF]

Frontiers in Cell and Developmental Biology
Gemcitabine, as a nucleoside analog, exerts a broad-spectrum antitumor effect by interfering with DNA synthesis, but its clinical application is limited by drug resistance.
Xuanrui Zhang, Bing Qi, Jing Chen
doaj   +2 more sources

Removal of misincorporated ribonucleotides from prokaryotic genomes: an unexpected role for nucleotide excision repair. [PDF]

PLoS Genetics, 2013
Stringent steric exclusion mechanisms limit the misincorporation of ribonucleotides by high-fidelity DNA polymerases into genomic DNA. In contrast, low-fidelity Escherichia coli DNA polymerase V (pol V) has relatively poor sugar discrimination and ...
Alexandra Vaisman, John P McDonald, Donald Huston, Wojciech Kuban, Lili Liu, Bennett Van Houten, Roger Woodgate   +6 more
doaj   +6 more sources

Antitumor Mechanism of Hydroxycamptothecin via the Metabolic Perturbation of Ribonucleotide and Deoxyribonucleotide in Human Colorectal Carcinoma Cells

Molecules, 2021
Hydroxycamptothecin (SN38) is a natural plant extract isolated from Camptotheca acuminate. It has a broad spectrum of anticancer activity through inhibition of DNA topoisomerase I, which could affect DNA synthesis and lead to DNA damage. Thus, the action
Yan Li, Wendi Luo, Huixia Zhang, Caiyun Wang, Caiyuan Yu, Zhihong Jiang, Wei Zhang   +6 more
doaj   +1 more source

The Ultimate (Mis)match: When DNA Meets RNA

Cells, 2021
RNA-containing structures, including ribonucleotide insertions, DNA:RNA hybrids and R-loops, have recently emerged as critical players in the maintenance of genome integrity.
Benoit Palancade, Rodney Rothstein
doaj   +1 more source

Characterisation of an Escherichia coli line that completely lacks ribonucleotide reduction yields insights into the evolution of parasitism and endosymbiosis

eLife, 2023
Life requires ribonucleotide reduction for de novo synthesis of deoxyribonucleotides. As ribonucleotide reduction has on occasion been lost in parasites and endosymbionts, which are instead dependent on their host for deoxyribonucleotide synthesis, it ...
Samantha DM Arras, Nellie Sibaeva, Ryan J Catchpole, Nobuyuki Horinouchi, Dayong Si, Alannah M Rickerby, Kengo Deguchi, Makoto Hibi, Koichi Tanaka, Michiki Takeuchi, Jun Ogawa, Anthony M Poole   +11 more
doaj   +1 more source

Mechanisms of nucleotide selection by telomerase

eLife, 2020
Telomerase extends telomere sequences at chromosomal ends to protect genomic DNA. During this process it must select the correct nucleotide from a pool of nucleotides with various sugars and base pairing properties, which is critically important for the ...
Matthew A Schaich, Samantha L Sanford, Griffin A Welfer, Samuel A Johnson, Thu H Khoang, Patricia L Opresko, Bret D Freudenthal   +6 more
doaj   +1 more source

Ribonucleotide and R-Loop Damage in Plastid DNA and Mitochondrial DNA during Maize Development

Plants, 2023
Although the temporary presence of ribonucleotides in DNA is normal, their persistence represents a form of DNA damage. Here, we assess such damage and damage defense to DNA in plastids and mitochondria of maize.
Diwaker Tripathi, Delene J. Oldenburg, Arnold J. Bendich   +2 more
doaj   +1 more source

A rapid and sensitive assay for quantifying the activity of both aerobic and anaerobic ribonucleotide reductases acting upon any or all substrates

PLoS ONE, 2022
Ribonucleotide reductases (RNRs) use radical-based chemistry to catalyze the conversion of all four ribonucleotides to deoxyribonucleotides. The ubiquitous nature of RNRs necessitates multiple RNR classes that differ from each other in terms of the ...
Talya S. Levitz, Gisele A. Andree, Rohan Jonnalagadda, Christopher D. Dawson, Rebekah E. Bjork, Catherine L. Drennan   +5 more
doaj   +2 more sources

Modulating pyrimidine ribonucleotide levels for the treatment of cancer

Cancer & Metabolism, 2020
By providing the necessary building blocks for nucleic acids and precursors for cell membrane synthesis, pyrimidine ribonucleotides are essential for cell growth and proliferation.
Tanzina Mollick, Sonia Laín
doaj   +1 more source