Results 1 to 10 of about 48,825 (277)
Convergent allostery in ribonucleotide reductase [PDF]
Nature Communications, 2019 Ribonucleotide reductase (RNR) catalyzes the conversion of ribonucleotides to deoxyribonucleotides, which is an essential step in DNA synthesis. Here the authors use small-angle X-ray scattering, X-ray crystallography, and cryo-electron microscopy to ...
William C. Thomas +7 more
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The Origin and Evolution of Ribonucleotide Reduction [PDF]
Life, 2015 Ribonucleotide reduction is the only pathway for de novo synthesis of deoxyribonucleotides in extant organisms. This chemically demanding reaction, which proceeds via a carbon-centered free radical, is catalyzed by ribonucleotide reductase (RNR).
Daniel Lundin +3 more
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Modulating pyrimidine ribonucleotide levels for the treatment of cancer
Cancer & Metabolism, 2020 By providing the necessary building blocks for nucleic acids and precursors for cell membrane synthesis, pyrimidine ribonucleotides are essential for cell growth and proliferation.
Tanzina Mollick, Sonia Laín
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Current perspectives on mechanisms of ribonucleotide incorporation and processing in mammalian DNA
Genes and Environment, 2019 Ribonucleotides, which are RNA precursors, are often incorporated into DNA during replication. Although embedded ribonucleotides in the genome are efficiently removed by canonical ribonucleotide excision repair (RER), inactivation of RER causes genomic ...
Akira Sassa +2 more
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eLife, 2016 Ribonucleotide reductase (RNR) converts ribonucleotides to deoxyribonucleotides, a reaction that is essential for DNA biosynthesis and repair. This enzyme is responsible for reducing all four ribonucleotide substrates, with specificity regulated by the ...
Christina M Zimanyi +4 more
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Acetylation regulates ribonucleotide reductase activity and cancer cell growth
Nature Communications, 2019 Ribonucleotide reductase (RNR) catalyzes the de novo synthesis of deoxyribonucleoside diphosphates to provide dNTP precursors for DNA synthesis. Here the authors show that the availability of dNTPs, DNA replication, and cellular proliferation, are ...
Guo Chen +12 more
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Haematologica, 2014 Myeloproliferative neoplasms are a varied group of disorders that can have prolonged chronic phases, but eventually accelerate and can transform into a secondary acute myeloid leukemia that is ultimately fatal.
Joshua F. Zeidner +11 more
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Structural insights into the initiation of free radical formation in the Class Ib ribonucleotide reductases in Mycobacteria [PDF]
Current Research in Structural BiologyClass I ribonucleotide reductases consisting of α and β subunits convert ribonucleoside diphosphates to deoxyribonucleoside diphosphates involving an intricate free radical mechanism.
Lumbini R. Yadav +3 more
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Molecules, 2021 Hydroxycamptothecin (SN38) is a natural plant extract isolated from Camptotheca acuminate. It has a broad spectrum of anticancer activity through inhibition of DNA topoisomerase I, which could affect DNA synthesis and lead to DNA damage. Thus, the action
Yan Li +6 more
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The Ultimate (Mis)match: When DNA Meets RNA
Cells, 2021 RNA-containing structures, including ribonucleotide insertions, DNA:RNA hybrids and R-loops, have recently emerged as critical players in the maintenance of genome integrity.
Benoit Palancade, Rodney Rothstein
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