Results 101 to 110 of about 48,825 (277)

Gene Therapy Rescues Cardiac Dysfunction in Duchenne Muscular Dystrophy Mice by Elevating Cardiomyocyte Deoxy-Adenosine Triphosphate

JACC: Basic to Translational Science, 2019
Summary: Mutations in the gene encoding for dystrophin leads to structural and functional deterioration of cardiomyocytes and is a hallmark of cardiomyopathy in Duchenne muscular dystrophy (DMD) patients.
Stephen C. Kolwicz, Jr., PhD, John K. Hall, PhD, Farid Moussavi-Harami, MD, Xiolan Chen, PhD, Stephen D. Hauschka, PhD, Jeffrey S. Chamberlain, PhD, Michael Regnier, PhD, Guy L. Odom, PhD   +7 more
doaj  

Bcl2 induces DNA replication stress by inhibiting ribonucleotide reductase.

Cancer Research, 2014
DNA replication stress is an inefficient DNA synthesis process that leads replication forks to progress slowly or stall. Two main factors that cause replication stress are alterations in pools of deoxyribonucleotide (dNTP) precursors required for DNA ...
Maohua Xie, Y. Yen, T. Owonikoko, S. Ramalingam, F. Khuri, W. Curran, P. Doetsch, Xingming Deng   +7 more
semanticscholar   +1 more source

Lipid Nanoparticles for Delivery of CRISPR Gene Editing Components

Small Methods, EarlyView.
The review presents a comprehensive overview of each component of lipid nanoparticles（LNPs）and their effects on editing efficiency. It specifically highlights strategies for achieving non‐liver delivery, aiming for broader applications in gene editing. Furthermore, this review summarizes the applications of LNPs in gene editing and offers insights for ...
Fan Wu, Nei Li, Yudian Xiao, Rohan Palanki, Hannah Yamagata, Michael J. Mitchell, Xuexiang Han   +6 more
wiley   +1 more source

The Enhanced Tumor Specificity of TG6002, an Armed Oncolytic Vaccinia Virus Deleted in Two Genes Involved in Nucleotide Metabolism

Molecular Therapy: Oncolytics, 2019
Oncolytic vaccinia viruses are currently in clinical development. However, the safety and the tumor selectivity of these oncolytic viruses must be improved.
Johann Foloppe, Juliette Kempf, Nicolas Futin, Jacqueline Kintz, Pascale Cordier, Christelle Pichon, Annie Findeli, Fabien Vorburger, Eric Quemeneur, Philippe Erbs   +9 more
doaj  

Deciphering diverse cell‐death patterns to predict the prognosis and potential therapy target of hepatocellular carcinoma patients

VIEW, EarlyView.
Abstract Ninety percent of all primary liver malignancies are hepatocellular carcinomas (HCC), making liver cancer the third most common cause of cancer‐associated mortality. Different patterns of programmed cell death (PCD) are crucial for the survival of tumors, and they might serve as a prognostic marker for HCC.
Lin Ding, Qian Li, Wenjing Yang, Te Liu, Tongtong Tian, Yu Liu, Chunyan Zhang, Baishen Pan, Beili Wang, Fan Wu, Wei Guo   +10 more
wiley   +1 more source

Structure-guided design of anti-cancer ribonucleotide reductase inhibitors

Journal of Enzyme Inhibition and Medicinal Chemistry, 2019
Ribonucleotide reductase (RR) catalyses the rate-limiting step of dNTP synthesis, establishing it as an important cancer target. While RR is traditionally inhibited by nucleoside-based antimetabolites, we recently discovered a naphthyl salicyl acyl ...
Tessianna A. Misko, Yi-Ting Liu, Michael E. Harris, Nancy L. Oleinick, John Pink, Hsueh-Yun Lee, Chris G. Dealwis   +6 more
doaj   +1 more source

Choosing the Right Metal: Case Studies of Class I Ribonucleotide Reductases*

Journal of Biological Chemistry, 2014
Over one-third of all proteins require metallation for function (Waldron, K. J., Rutherford, J. C., Ford, D., and Robinson, N.J. (2009) Nature 460, 823–830).
Mingxia Huang, M. J. Parker, J. Stubbe
semanticscholar   +1 more source

Senescence Cell Induction Methods Display Diverse Metabolic Reprogramming and Reveal an Underpinning Serine/Taurine Reductive Metabolic Phenotype

Aging Cell, EarlyView.
This study reveals that in vitro senescence induction methods significantly influence intracellular biomolecular profiles, showing both shared and unique metabolic responses. A novel bioanalytical pipeline was developed to explore these subphenotypes, highlighting the importance of targeting metabolic redox circuits and serine/taurine pathways for ...
Domenica Berardi, Gillian Farrell, Abdullah AlSultan, Ashley McCulloch, Nicole M. Hall, Rui Pedro Pereira Sousa, Melanie Jimenez, Colin Selman, Ilaria Bellantuono, Caroline H. Johnson, Zahra Rattray, Nicholas J. W. Rattray   +11 more
wiley   +1 more source

Retinoblastoma vulnerability to combined de novo and salvage pyrimidine ribonucleotide synthesis pharmacologic blockage

Heliyon
Retinoblastoma is an eye cancer that commonly affects young children. Despite significant advances, current treatments cause side effects even when administered locally, and patients may still have to undergo enucleation.
Tanzina Mollick, Suhas Darekar, Basile Dalarun, Flavia Plastino, Juan Zhang, Andres Pastor Fernández, Twana Alkasalias, Helder André, Sonia Laín   +8 more
doaj  

Substrate Properties of Fluorescent Ribonucleotides in the Terminal Transferase-Catalyzed Labeling of DNA Sequencing Primers

BioTechniques, 1996
Terminal deoxynucleotidyltransferase (terminal transferase, E.C. 2.7.7.31) has been used to add a single fluorescent ribonucleotide to the 3′ terminus of DNA sequencing primers, thereby creating primers suitable for automated DNA sequence analysis.
Gabor L. Igloi
doaj   +1 more source