Results 111 to 120 of about 77,265 (266)
Experimental Physiology, EarlyView.Abstract The global prevalence of obesity and related metabolic disorders has spurred interdisciplinary research to develop new intervention strategies. Current research is increasingly focusing on the exercise‐induced browning of white adipose tissue and the mechanisms by which it improves energy metabolism.
Yuhui Su +4 more
wiley +1 more source
Acetylation regulates ribonucleotide reductase activity and cancer cell growth
Nature Communications, 2019 Ribonucleotide reductase (RNR) catalyzes the de novo synthesis of deoxyribonucleoside diphosphates to provide dNTP precursors for DNA synthesis. Here the authors show that the availability of dNTPs, DNA replication, and cellular proliferation, are ...
Guo Chen +12 more
doaj +1 more source
, 2018 Orotic acid is an intermediate found in the pathway for pyrimidine synthesis. The mitochondrial enzyme dihydroorotate dehydrogenase (DHODH) catalyzes the production of orotic acid by the conversion of the compound dihydroorotate to orotic acid.
Fonteh, Aliah L
core +1 more source
The Journal of Physiology, EarlyView.Abstract figure legend A schematic diagram outlining the concept of enviromimetics, and the subclasses of exercise mimetics, epimimetics and cognitomimetics. The rationale is that environmental stimulation and lifestyle factors, including physical activity and cognitive stimulation, have shown beneficial effects across a range of human conditions ...
Anthony J. Hannan
wiley +1 more source
Systemic Toxicity of L‐Mimosine in Rabbits: A Non‐Rodent Model for Safety Assessment
Journal of Applied Toxicology, Volume 46, Issue 2, Page 639-651, February 2026.ABSTRACT L‐mimosine is a non‐protein amino acid primarily found in the Mimosoideae subfamily, with high concentrations in Leucaena leucocephala and Mimosa pudica. These plants are widely used in both human and animal nutrition, as well as in phytotherapeutic applications. While the toxic effects of L‐mimosine have been extensively studied in ruminants,
S. M. Ferreira +6 more
wiley +1 more source
Microcondensate‐Mediated Intracellular Infusion of mRNA Across the Plasma Membrane
Angewandte Chemie, Volume 138, Issue 1, 2 January 2026.The delivery of mRNA without lipid nanoparticles remains challenging. FcB(L17E)3‐driven microcondensates with nucleic acids, aided by short ssDNA, enable coacervate formation, actin‐dependent cytosolic infusion, and in vivo protein expression, offering a potential platform for next‐generation mRNA therapeutics and vaccination.
Yoshimasa Kawaguchi +4 more
wiley +2 more sources
BMC Genomics, 2009 Background Ribonucleotide reductases (RNRs) catalyse the only known de novo pathway for deoxyribonucleotide synthesis, and are therefore essential to DNA-based life. While ribonucleotide reduction has a single evolutionary origin, significant differences
Poole Anthony M +3 more
doaj +1 more source
A ribonucleotide reductase inhibitor with deoxyribonucleoside‐reversible cytotoxicity [PDF]
, 2016 Mikael Crona +5 more
openalex +1 more source
Fasting as Medicine: Mitochondrial and Endothelial Rejuvenation in Vascular Aging
Aging Cell, Volume 25, Issue 2, February 2026.Aging impairs cerebrovascular health by driving mitochondrial dysfunction, oxidative stress, endothelial failure, and neurovascular uncoupling, leading to BBB breakdown and cognitive decline. In contrast, time‐restricted feeding/eating counteracts these mechanisms by restoring mitochondrial function, activating adaptive nutrient‐sensing pathways ...
Madison Milan +13 more
wiley +1 more source