Results 111 to 120 of about 48,825 (277)

The Steric Gate of DNA Polymerase ι Regulates Ribonucleotide Incorporation and Deoxyribonucleotide Fidelity*

Journal of Biological Chemistry, 2014
Background: Accurate bypass of DNA damage by translesion DNA polymerases is critical for cell survival. Results: Wild-type human DNA polymerase ι incorporates ribonucleotides, and a steric gate mutant increases both ribonucleotide incorporation and ...
K. Donigan, M. McLenigan, Wei Yang, M. Goodman, R. Woodgate   +4 more
semanticscholar   +1 more source

Niclosamide prodrug enhances oral bioavailability and efficacy against hepatocellular carcinoma by targeting vasorin‐TGFβ signalling

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Hepatocellular carcinoma (HCC), the third leading cause of cancer‐related deaths worldwide, has limited treatment options and high mortality rate. We previously used a bioinformatics approach to identify niclosamide (NIC) as a promising repurposed drug candidate for HCC.
Mingdian Tan, Wei Ye, Yi Liu, Xiaowu Chen, Lakshmi Huttad, Mei‐Sze Chua, Samuel So   +6 more
wiley   +1 more source

Structure-based in silico investigation of antagonists of human ribonucleotide reductase from Annona muricata

Informatics in Medicine Unlocked, 2023
Human ribonucleotide reductase (HRR) also known as ribonuceotide diphosphate reductase catalyzes the conversion of ribonucleotide to deoxyribonuceotides which is the rate limiting step in the synthesis of DNA, establishing the enzyme as a vital ...
Damilola A. Omoboyowa, Damilola S. Bodun, Jamiyu A. Saliu   +2 more
doaj  

Universal Restriction Site-Free Cloning Method Using Chimeric Primers

BioTechniques, 2002
A universal restriction site-free cloning method has been developed to precisely insert a DNA fragment into a vector at any desired location without altering any nucleotide(s) in either the DNA fragment or the vector.
Guo Jun Chen, Nahong Qiu, Malcolm G.P. Page   +2 more
doaj   +1 more source

Transcription‐coupled repair: tangled up in convoluted repair

The FEBS Journal, EarlyView.
In this review, we discuss recent findings derived from diverse genomic, biochemical and structural, imaging, and functional studies (B–E) that culminated in deep mechanistic insight (A) into the vital cellular process of transcription‐coupled nucleotide excision repair (TC‐NER).
Diana A. Llerena Schiffmacher, Yun Jin Pai, Alex Pines, Wim Vermeulen   +3 more
wiley   +1 more source

INDUCTION BY AN RNA PHAGE OF AN ENZYME CATALYZING INCORPORATION OF RIBONUCLEOTIDES INTO RIBONUCLEIC ACID [PDF]

, 1963
Charles Weissmann, Lionel N. Simon, Severo Ochoa   +2 more
openalex   +1 more source

Human FASTK preferentially binds single‐stranded and G‐rich RNA

The FEBS Journal, EarlyView.
Although FASTK is known to play a role in mRNA biology, the mechanism through which it recognizes RNA has yet to be unraveled. Here, we used purified human FASTK to characterize its RNA‐binding properties in vitro. We found that FASTK prefers ssRNA oligonucleotides containing guanines with the potential to form G‐quadruplexes and binds robustly to any ...
Daria M. Dawidziak, Dawid A. Dzadz, Mikołaj I. Kuska, Madhuri Kanavalli, Maria M. Klimecka, Matthew Merski, Katarzyna J. Bandyra, Maria W. Górna   +7 more
wiley   +1 more source

An HWE‐Family Histidine Kinase Modulates Brucella Cell Envelope Properties and Host Innate Immune Response

Molecular Microbiology, EarlyView.
The HWE‐family histidine kinase PhyK regulates the cell envelope structure of the intracellular pathogen Brucella ovis and affects how the host immune system responds to this bacterium. Deletion of phyK alters bacterial survival in the face of detergent stress and reduces immune activation in infected macrophages.
Xingru Chen, Emily Perez, Eleanor C. Scheeres, Rosemary Northcote, Aretha Fiebig, Andrew J. Olive, Sean Crosson   +6 more
wiley   +1 more source

TERMINAL-SEQUENCE STUDIES OF HIGH-MOLECULAR-WEIGHT RIBONUCLEIC. THE REACTION OF PERIODATE-OXIDIZED RIBONUCLEOSIDES, 5′-RIBONUCLEOTIDES AND RIBONUCLEIC ACID WITH ISONIAZID [PDF]

, 1965
John A. Hunt
openalex   +1 more source

ARABIDOPSIS HOMOLOG OF TRITHORAX1 impacts lateral root development by epigenetic regulation of targets involved in root system architecture

New Phytologist, EarlyView.
Summary Developmental processes are regulated at multiple levels, including the epigenetic level. Among the epigenetic factors, histone H3 lysine 4 (H3K4) methyltransferases contribute to active transcription of target genes, and here, we explored how the H3K4 methyltransferase ARABIDOPSIS HOMOLOG OF TRITHORAX1 (ATX1) affects Arabidopsis thaliana ...
Selene Napsucialy‐Mendivil, Héctor H. Torres‐Martínez, Gustavo Rodríguez‐Alonso, Diana Marcela Rivera‐Toro, Raúl Alvarez‐Venegas, Marco Adán Júarez‐Verdayes, Svetlana Shishkova, Joseph G. Dubrovsky   +7 more
wiley   +1 more source