Results 11 to 20 of about 48,825 (277)

The periodic table of ribonucleotide reductases [PDF]

Journal of Biological Chemistry, 2021
In most organisms, transition metal ions are necessary cofactors of ribonucleotide reductase (RNR), the enzyme responsible for biosynthesis of the 2'-deoxynucleotide building blocks of DNA. The metal ion generates an oxidant for an active site cysteine (Cys), yielding a thiyl radical that is necessary for initiation of catalysis in all RNRs.
Terry B. Ruskoski, A. Boal
semanticscholar   +4 more sources

Ribonucleases and Ribonucleotides in Liver Tumours [PDF]

British Journal of Cancer, 1958
E. Emmet Reid, F Lotz
openalex   +4 more sources

Ribonucleotide incorporation into DNA during DNA replication and its consequences

Critical reviews in biochemistry and molecular biology, 2021
Ribonucleotides are the most abundant non-canonical nucleotides in the genome. Their vast presence and influence over genome biology is becoming increasingly appreciated.
Zhi-Xiong Zhou, Jessica S. Williams, S. Lujan, T. Kunkel   +3 more
semanticscholar   +1 more source

Characterisation of an Escherichia coli line that completely lacks ribonucleotide reduction yields insights into the evolution of parasitism and endosymbiosis

eLife, 2023
Life requires ribonucleotide reduction for de novo synthesis of deoxyribonucleotides. As ribonucleotide reduction has on occasion been lost in parasites and endosymbionts, which are instead dependent on their host for deoxyribonucleotide synthesis, it ...
Samantha DM Arras, Nellie Sibaeva, Ryan J Catchpole, Nobuyuki Horinouchi, Dayong Si, Alannah M Rickerby, Kengo Deguchi, Makoto Hibi, Koichi Tanaka, Michiki Takeuchi, Jun Ogawa, Anthony M Poole   +11 more
doaj   +1 more source

Mechanisms of nucleotide selection by telomerase

eLife, 2020
Telomerase extends telomere sequences at chromosomal ends to protect genomic DNA. During this process it must select the correct nucleotide from a pool of nucleotides with various sugars and base pairing properties, which is critically important for the ...
Matthew A Schaich, Samantha L Sanford, Griffin A Welfer, Samuel A Johnson, Thu H Khoang, Patricia L Opresko, Bret D Freudenthal   +6 more
doaj   +1 more source

Ribonucleotide Reductases: Structure, Chemistry, and Metabolism Suggest New Therapeutic Targets.

Annual Review of Biochemistry, 2020
Ribonucleotide reductases (RNRs) catalyze the de novo conversion of nucleotides to deoxynucleotides in all organisms, controlling their relative ratios and abundance.
Brandon L. Greene, Gyunghoon Kang, C. Cui, M. Bennati, D. Nocera, C. Drennan, J. Stubbe   +6 more
semanticscholar   +1 more source

Structure of a trapped radical transfer pathway within a ribonucleotide reductase holocomplex

Science, 2020
Caught in the act Proton-coupled electron transfer (PCET) is an important process for moving electrons through proteins and requires precise positioning of suitable proton and electron carriers. Kang et al. determined a cryo–electron microscopy structure
Gyunghoon Kang, Alexander T. Taguchi, J. Stubbe, C. Drennan   +3 more
semanticscholar   +1 more source

Dehydration of Ribonucleotides Catalyzed by Ribonucleotide Reductase: The Role of the Enzyme [PDF]

Biophysical Journal, 2006
This article focuses on the second step of the catalytic mechanism for the reduction of ribonucleotides catalyzed by the enzyme Ribonucleotide Reductase (RNR). This step corresponds to the protonation/elimination of the substrate's C-2' hydroxyl group.
Leif A. Eriksson, Maria J. Ramos, Pedro A. Fernandes, Nuno M. F. S. A. Cerqueira   +3 more
openaire   +3 more sources

Ribonucleotide and R-Loop Damage in Plastid DNA and Mitochondrial DNA during Maize Development

Plants, 2023
Although the temporary presence of ribonucleotides in DNA is normal, their persistence represents a form of DNA damage. Here, we assess such damage and damage defense to DNA in plastids and mitochondria of maize.
Diwaker Tripathi, Delene J. Oldenburg, Arnold J. Bendich   +2 more
doaj   +1 more source

A rapid and sensitive assay for quantifying the activity of both aerobic and anaerobic ribonucleotide reductases acting upon any or all substrates

PLoS ONE, 2022
Ribonucleotide reductases (RNRs) use radical-based chemistry to catalyze the conversion of all four ribonucleotides to deoxyribonucleotides. The ubiquitous nature of RNRs necessitates multiple RNR classes that differ from each other in terms of the ...
Talya S. Levitz, Gisele A. Andree, Rohan Jonnalagadda, Christopher D. Dawson, Rebekah E. Bjork, Catherine L. Drennan   +5 more
doaj   +2 more sources