Results 21 to 30 of about 77,265 (266)

Teratogenic effect of Disodium 5’ Ribonucleotide (E635) on 15th day chick embryo Gallus gallus (Research note) [PDF]

Poultry Science Journal
Disodium 5' ribonucleotide (E635), commonly used as a food additive, may pose teratogenic risks. The study aimed to evaluate the teratogenicity of disodium 5’ ribonucleotide using chick embryos as an in vivo model. Fertilized chicken eggs were inoculated
Shaiba Sharikmaslat, Nitin Kamble
doaj   +1 more source

Spd2 assists Spd1 in modulation of RNR architecture but does not regulate deoxynucleotide pools [PDF]

, 2014
In yeasts, small intrinsically disordered proteins (IDPs) modulate ribonucleotide reductase (RNR) activity to ensure an optimal supply of dNTPs for DNA synthesis. The S. pombe Spd1 protein can directly inhibit the large RNR subunit (R1), import the small
Basrai, Beck, Bester, Bähler, Chabes, Danielsson, Elledge, Fairman, Fleck, Halazonetis, Hofer, Holmberg, Holmberg, Håkansson, Kjaerulff, Knutsen, Lee, Liu, Liu, Marguerat, Maundrell, Moreno, Moss, Nestoras, Nielsen, Nordlund, Reichard, Rhind, Salguero, Tompa, Uchiki, Weinberg, Woollard, Wu, Yoshida, Zhao, Zhao, Zolezzi   +37 more
core   +1 more source

Current perspectives on mechanisms of ribonucleotide incorporation and processing in mammalian DNA

Genes and Environment, 2019
Ribonucleotides, which are RNA precursors, are often incorporated into DNA during replication. Although embedded ribonucleotides in the genome are efficiently removed by canonical ribonucleotide excision repair (RER), inactivation of RER causes genomic ...
Akira Sassa, Manabu Yasui, Masamitsu Honma   +2 more
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The CRISPR-Cas9 crATIC HeLa transcriptome: Characterization of a novel cellular model of ATIC deficiency and ZMP accumulation

Molecular Genetics and Metabolism Reports, 2020
In de novo purine biosynthesis (DNPS), 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase (EC 2.1.2.3)/inosine monophosphate cyclohydrolase (EC 3.5.4.10) (ATIC) catalyzes the last two reactions of the pathway: conversion of 5-aminoimidazole ...
Randall C. Mazzarino, Veronika Baresova, Marie Zikánová, Nathan Duval, Terry G. Wilkinson, II, David Patterson, Guido N. Vacano   +6 more
doaj   +1 more source

Transiently Transfected Purine Biosynthetic Enzymes Form Stress Bodies [PDF]

, 2013
It has been hypothesized that components of enzymatic pathways might organize into intracellular assemblies to improve their catalytic efficiency or lead to coordinate regulation.
Cook, Lindsey, Ellington, Andrew D., Marcotte, Edward M., Swaminathan, Jagannath, Tsechansky, Mark, Zhao, Alice   +5 more
core   +7 more sources

Analysis of the ex vivo and in vivo antiretroviral activity of gemcitabine. [PDF]

PLoS ONE, 2011
Replication of retroviral and host genomes requires ribonucleotide reductase to convert rNTPs to dNTPs, which are then used as substrates for DNA synthesis.
Christine L Clouser, Colleen M Holtz, Mary Mullett, Duane L Crankshaw, Jacquie E Briggs, Jay Chauhan, Ilze Matise VanHoutan, Steven E Patterson, Louis M Mansky   +8 more
doaj   +1 more source

ATR inhibition facilitates targeting of leukemia dependence on convergent nucleotide biosynthetic pathways. [PDF]

, 2017
Leukemia cells rely on two nucleotide biosynthetic pathways, de novo and salvage, to produce dNTPs for DNA replication. Here, using metabolomic, proteomic, and phosphoproteomic approaches, we show that inhibition of the replication stress sensing kinase ...
Abt, Evan R, Braas, Daniel, Capri, Joseph R, Cheng, Chloe M, Czernin, Johannes, Donahue, Timothy R, Faull, Kym F, Herschman, Harvey R, Kim, Woosuk, Kornblum, Harley I, Le, Thuc M, Merkurjev, Daria, Nikanjam, Mina, Poddar, Soumya, Radu, Caius G, Ribas, Antoni, Rix, Peter, Uong, Nhu T, Wei, Liu, Whitelegge, Julian, Zaretsky, Jesse   +20 more
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Ribonucleotides in bacterial DNA [PDF]

Critical Reviews in Biochemistry and Molecular Biology, 2014
In all living cells, DNA is the storage medium for genetic information. Being quite stable, DNA is well-suited for its role in storage and propagation of information, but RNA is also covalently included in DNA through various mechanisms. Recent studies also demonstrate useful aspects of including ribonucleotides in the genome during repair.
Jeremy W, Schroeder, Justin R, Randall, Lindsay A, Matthews, Lyle A, Simmons   +3 more
openaire   +2 more sources

Challenges of drug resistance in the management of pancreatic cancer [PDF]

, 2010
The current treatment of choice for metastatic pancreatic cancer involves single agent gemcitabine or combination of gemcitabine with capecitabine and erlotinib (tyrosine kinase inhibitor).
Akada, Allison, Almoguera, Andreetta, Arai, Arlt, Arteaga, Arumugam, Asano, Bachem, Baldwin, Banerjee, Bartsch, Bergers, Best, Bold, Bondar, Buck, Burris, Chakravarti, Chakravarti, Choi, Cunningham, Cunningham, Dancer, Dong, Duxbury, Duxbury, Duxbury, Duxbury, Engelman, Feldmann, Ferrero, Galmarini, Geyer, Giovannetti, Goan, Greer, Hagmann, Hahn, Henke, Hruban, Humeniuk, Ischenko, Ishikawa, Itoi, Jansen, Karapetis, Kindler, Kong, Koopman, Kulik, Lei, Lemoine, Liau, Liau, Longley, Mackey, Mackey, Mackey, Mahon, Mamaghani, Marechal, Marmor, Martin Clynes, Mata, Maxwell, Mendelsohn, Meropol, Miwa, Moertel, Molina-Arcas, Moore, Morgillo, Moriyama, Muerkoster, Muerkoster, Nakahira, Nakajima, Nakano, Naomi Walsh, Nishimura, Oguri, Okamoto, Okumura, Olive, O’Driscoll, Pao, Park, Park, Peters, Plunkett, Ray McDermott, Ritzel, Rizwan Sheikh, Robert O’Connor, Ruggeri, Safran, Saito, Sakamoto, Schuller, Sebastiani, Shah, Shi, Simon, Spratlin, Takao, Takebayashi, Treat, Tsukamoto, Tzeng, Vaishampayan, Van Cutsem, van der Wilt, Wang, Wang, Wang, Xiong, Yamasaki, Yokoi   +119 more
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Ribonucleotide reductase subunit switching in hepatoblastoma drug response and relapse

Communications Biology, 2023
In hepatoblastoma, the RRM2 subunit of ribonucleotide reductase is associated with disease progression, but in response to chemotherapy, subunit switching favours the less active RRM2B subunit which supports hepatoblastoma cell survival and relapse.
Anthony Brown, Qingfei Pan, Li Fan, Emilie Indersie, Cheng Tian, Nikolai Timchenko, Liyuan Li, Baranda S. Hansen, Haiyan Tan, Meifen Lu, Junmin Peng, Shondra M. Pruett-Miller, Jiyang Yu, Stefano Cairo, Liqin Zhu   +14 more
doaj   +1 more source