Results 31 to 40 of about 48,825 (277)

Teratogenic effect of Disodium 5’ Ribonucleotide (E635) on 15th day chick embryo Gallus gallus (Research note) [PDF]

Poultry Science Journal
Disodium 5' ribonucleotide (E635), commonly used as a food additive, may pose teratogenic risks. The study aimed to evaluate the teratogenicity of disodium 5’ ribonucleotide using chick embryos as an in vivo model. Fertilized chicken eggs were inoculated
Shaiba Sharikmaslat, Nitin Kamble
doaj   +1 more source

Analysis of the ex vivo and in vivo antiretroviral activity of gemcitabine. [PDF]

PLoS ONE, 2011
Replication of retroviral and host genomes requires ribonucleotide reductase to convert rNTPs to dNTPs, which are then used as substrates for DNA synthesis.
Christine L Clouser, Colleen M Holtz, Mary Mullett, Duane L Crankshaw, Jacquie E Briggs, Jay Chauhan, Ilze Matise VanHoutan, Steven E Patterson, Louis M Mansky   +8 more
doaj   +1 more source

TAS1553, a small molecule subunit interaction inhibitor of ribonucleotide reductase, exhibits antitumor activity by causing DNA replication stress

Communications Biology, 2022
A small-molecule protein-protein interaction inhibitor of ribonucleotide reductase subunit, TAS1553, is shown to inhibit growth of both hematological and solid cancer xenograft tumors following oral administration in mice.
Hiroyuki Ueno, Takuya Hoshino, Wakako Yano, Sayaka Tsukioka, Takamasa Suzuki, Shoki Hara, Yoshio Ogino, Khoon Tee Chong, Tatsuya Suzuki, Shingo Tsuji, Hikaru Itadani, Ikuo Yamamiya, Yoshihiro Otsu, Satoshi Ito, Toshiya Yonekura, Miki Terasaka, Nozomu Tanaka, Seiji Miyahara   +17 more
doaj   +1 more source

Stereoselective Synthesis of β-Glycinamide Ribonucleotide

Molecules, 2022
A diastereoselective synthesis of the β-anomer of glycinamide ribonucleotide (β-GAR) has been developed. The synthesis was accomplished in nine steps from D-ribose and occurred in 5% overall yield. The route provided material on the multi-milligram scale.
Lisa Ngu, Debarpita Ray, Samantha S. Watson, Penny J. Beuning, Mary Jo Ondrechen, George A. O’Doherty   +5 more
doaj   +1 more source

A Conserved Mechanism of APOBEC3 Relocalization by Herpesviral Ribonucleotide Reductase Large Subunits

Journal of Virology, 2019
The APOBEC3 family of DNA cytosine deaminases constitutes a vital innate immune defense against a range of different viruses. A novel counterrestriction mechanism has recently been uncovered for the gammaherpesvirus EBV, in which a subunit of the viral ...
A. Cheng, Sofia N. Moraes, Claire Attarian, Jaime Yockteng-Melgar, Matthew C. Jarvis, Matteo Biolatti, Ganna Galitska, Valentina Dell’Oste, L. Frappier, Craig J. Bierle, S. Rice, R. Harris   +11 more
semanticscholar   +1 more source

Ribonucleotide reductase subunit switching in hepatoblastoma drug response and relapse

Communications Biology, 2023
In hepatoblastoma, the RRM2 subunit of ribonucleotide reductase is associated with disease progression, but in response to chemotherapy, subunit switching favours the less active RRM2B subunit which supports hepatoblastoma cell survival and relapse.
Anthony Brown, Qingfei Pan, Li Fan, Emilie Indersie, Cheng Tian, Nikolai Timchenko, Liyuan Li, Baranda S. Hansen, Haiyan Tan, Meifen Lu, Junmin Peng, Shondra M. Pruett-Miller, Jiyang Yu, Stefano Cairo, Liqin Zhu   +14 more
doaj   +1 more source

Molecular and physiological consequences of faulty eukaryotic ribonucleotide excision repair

EMBO Journal, 2019
The duplication of the eukaryotic genome is an intricate process that has to be tightly safe‐guarded. One of the most frequently occurring errors during DNA synthesis is the mis‐insertion of a ribonucleotide instead of a deoxyribonucleotide ...
Vanessa Kellner, B. Luke
semanticscholar   +1 more source

Inhibition of the glutaredoxin and thioredoxin systems and ribonucleotide reductase by mutant p53-targeting compound APR-246

Scientific Reports, 2018
The tumor suppressor p53 is commonly inactivated in human tumors, allowing evasion of p53-dependent apoptosis and tumor progression. The small molecule APR-246 (PRIMA-1Met) can reactive mutant p53 in tumor cells and trigger cell death by apoptosis.
Lena Haffo, Jun Lu, V. Bykov, S. Martin, X. Ren, L. Coppo, K. Wiman, A. Holmgren   +7 more
semanticscholar   +1 more source

Inhibitors of the Cancer Target Ribonucleotide Reductase, Past and Present

Biomolecules, 2022
Ribonucleotide reductase (RR) is an essential multi-subunit enzyme found in all living organisms; it catalyzes the rate-limiting step in dNTP synthesis, namely, the conversion of ribonucleoside diphosphates to deoxyribonucleoside diphosphates.
Sarah E. Huff, Jordan M. Winter, Chris G. Dealwis   +2 more
doaj   +1 more source

Advances of Ribonucleotide Reductase Inhibitors on Cancer

Zhongliu Fangzhi Yanjiu, 2019
Ribonucleotide reductase (RR) regulates dNTP production, catalyzing the reduction of ribonucleotide into deoxyribonucleotide diphosphate, which is essential in DNA synthesis and cell proliferation.
WANG An'ge, WU Zhe, WANG Li, QIU Yunqing
doaj   +1 more source