Results 41 to 50 of about 77,265 (266)
Stereoselective Synthesis of β-Glycinamide Ribonucleotide
Molecules, 2022 A diastereoselective synthesis of the β-anomer of glycinamide ribonucleotide (β-GAR) has been developed. The synthesis was accomplished in nine steps from D-ribose and occurred in 5% overall yield. The route provided material on the multi-milligram scale.
Lisa Ngu +5 more
doaj +1 more source
Genome-wide DNA hypomethylation and RNA:DNA hybrid accumulation in Aicardi-Goutières syndrome. [PDF]
, 2015 Aicardi-Goutières syndrome (AGS) is a severe childhood inflammatory disorder that shows clinical and genetic overlap with systemic lupus erythematosus (SLE).
Chédin, Frédéric +4 more
core +2 more sources
Angewandte Chemie, EarlyView.Here, we transform this otherwise destructive enzymatic activity into a powerful diagnostic advantage through an RNase I–assisted rolling circle amplification (RI‐RCA) strategy. By integrating controlled RNase I–mediated RNA digestion with circular DNA templates, this approach enables direct and highly sensitive detection of target RNA sequences. Using
Amal Mathai +5 more
wiley +2 more sources
Ribonucleotide reductase inhibitors: a new look at an old target for radiosensitization
Frontiers in Oncology, 2012 Ribonucleotide reductase, the rate limiting enzyme in the synthesis and repair of DNA, has been studied as a target for inhibition in the treatment of cancer for many years.
Tobias eChapman, Timothy James Kinsella
doaj +1 more source
Spectroscopic and theoretical approaches for studying radical reactions in class I ribonucleotide reductase [PDF]
, 2005 Ribonucleotide reductases (RNRs) catalyze the production of deoxyribonucleotides, which are essential for DNA synthesis and repair in all organisms.
Atkin +17 more
core +2 more sources
Studying Ribonucleotide Incorporation: Strand-specific Detection of Ribonucleotides in the Yeast Genome and Measuring Ribonucleotide-induced Mutagenesis [PDF]
Journal of Visualized Experiments, 2018 The presence of ribonucleotides in nuclear DNA has been shown to be a source of genomic instability. The extent of ribonucleotide incorporation can be assessed by alkaline hydrolysis and gel electrophoresis as RNA is highly susceptible to hydrolysis in alkaline conditions.
Zhi-Xiong, Zhou +2 more
openaire +2 more sources
The Origin and Evolution of Ribonucleotide Reduction
Life, 2015 Ribonucleotide reduction is the only pathway for de novo synthesis of deoxyribonucleotides in extant organisms. This chemically demanding reaction, which proceeds via a carbon-centered free radical, is catalyzed by ribonucleotide reductase (RNR).
Daniel Lundin +3 more
doaj +1 more source
Inhibitors of the Cancer Target Ribonucleotide Reductase, Past and Present
Biomolecules, 2022 Ribonucleotide reductase (RR) is an essential multi-subunit enzyme found in all living organisms; it catalyzes the rate-limiting step in dNTP synthesis, namely, the conversion of ribonucleoside diphosphates to deoxyribonucleoside diphosphates.
Sarah E. Huff +2 more
doaj +1 more source
Structural basis for proficient oxidized ribonucleotide insertion in double strand break repair
Nature Communications, 2021 The authors previously showed that pol μ lacks discrimination against oxidized dGTP (8-oxo-dGTP). Here they reveal the structural basis for proficient oxidized ribonucleotide (8-oxo-rGTP) incorporation during double strand break repair by pol μ.
Joonas A. Jamsen +5 more
doaj +1 more source
JACC: Basic to Translational Science, 2019 Summary: Mutations in the gene encoding for dystrophin leads to structural and functional deterioration of cardiomyocytes and is a hallmark of cardiomyopathy in Duchenne muscular dystrophy (DMD) patients.
Stephen C. Kolwicz, Jr., PhD +7 more
doaj +1 more source