Results 41 to 50 of about 48,825 (277)
Frontiers in Microbiology, 2023 IntroductionRibonucleotide reductase (RR) is essential for the replication of the double-stranded DNA virus CyHV-2 due to its ability to catalyze the conversion of ribonucleotides to deoxyribonucleotides, and is a potential target for the development of ...
Wenjie Cheng +24 more
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Proceedings of the National Academy of Sciences of the United States of America, 2018 Significance Conversion of ribonucleotides to the 2′-deoxyribonucleotides required for DNA biosynthesis is catalyzed by ribonucleotide reductases (RNRs) via a free-radical mechanism.
Elizabeth J. Blaesi +17 more
semanticscholar +1 more source
Ribonucleotide reductase inhibitors: a new look at an old target for radiosensitization
Frontiers in Oncology, 2012 Ribonucleotide reductase, the rate limiting enzyme in the synthesis and repair of DNA, has been studied as a target for inhibition in the treatment of cancer for many years.
Tobias eChapman, Timothy James Kinsella
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Ribonucleotide incorporation enables repair of chromosome breaks by nonhomologous end joining
Science, 2018 RNA takes over DNA repair Damage to DNA genomes is normally thought to be repaired with DNA. Pryor et al. now describe a clear exception (see the Perspective by Modesti).
J. Pryor +6 more
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Angewandte Chemie, EarlyView.A stress‐responsive folding promotor was developed by conjugating metal‐binding ligands and a redox‐active disulfide. The oxidative strength of the bifunctional disulfide was enhanced by metal coordination, inhibiting protein misfolding and up‐regulating the oxidative folding capacity under metal stress.
Keita Mori +8 more
wiley +2 more sources
Foods, 2021 Carcass composition, meat quality, calpain activity, fatty acid composition, and ribonucleotide content were examined and compared between male Southern Thai native goats (NG, n = 10) and three-way crossbred goats (CG, 50% Boer × 25% Saanen × 25 ...
Chanporn Chaosap +5 more
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Ribonucleotide Excision Repair Is Essential to Prevent Squamous Cell Carcinoma of the Skin.
Cancer Research, 2018 Because of imperfect discrimination against ribonucleoside triphosphates by the replicative DNA polymerases, large numbers of ribonucleotides are incorporated into the eukaryotic nuclear genome during S-phase.
Björn Hiller +11 more
semanticscholar +1 more source
Structural basis for proficient oxidized ribonucleotide insertion in double strand break repair
Nature Communications, 2021 The authors previously showed that pol μ lacks discrimination against oxidized dGTP (8-oxo-dGTP). Here they reveal the structural basis for proficient oxidized ribonucleotide (8-oxo-rGTP) incorporation during double strand break repair by pol μ.
Joonas A. Jamsen +5 more
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The binding of streptomycin to ribonucleotides.
The Journal of Antibiotics, 1979 Incubation of streptomycin (SM) with [32P]5'-ribonucleotides at pH 7.0 produces fractions that migrate towards the cathode in high voltage electrophoresis (HVE) separations at pH 3.5. SM appears to interact with pG, pA and pC but not with pU. The appearance of these [32P]-labeled fractions is dependent on incubation time and SM concentration ...
Elizabeth Bagley +3 more
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Syntheses of some fluorescent ribonucleotides [PDF]
Nucleic Acids Research, 1980 Synthesis of guanosine 3'-phosphodiesters of 1, N6-ethenoadenosine-2-sulfonate or 1, N6-etheno-2-azaadenosine can be done readily with ribonuclease N1. There is a 10-fold difference in quantum yield between the phosphodiesters and the starting fluorescent nucleosides.
K.F. Yip, K.C. Tsou
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