Results 1 to 10 of about 196,005 (260)
Convergent allostery in ribonucleotide reductase [PDF]
Nature Communications, 2019 Ribonucleotide reductase (RNR) catalyzes the conversion of ribonucleotides to deoxyribonucleotides, which is an essential step in DNA synthesis. Here the authors use small-angle X-ray scattering, X-ray crystallography, and cryo-electron microscopy to ...
William C. Thomas +7 more
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Inhibitors of the Cancer Target Ribonucleotide Reductase, Past and Present [PDF]
Biomolecules, 2022 Ribonucleotide reductase (RR) is an essential multi-subunit enzyme found in all living organisms; it catalyzes the rate-limiting step in dNTP synthesis, namely, the conversion of ribonucleoside diphosphates to deoxyribonucleoside diphosphates.
Sarah E. Huff +2 more
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Ribonucleotide Reductase [PDF]
Allosteric Enzymes, 2020 Ribonucleotide Reductase is a heterodimeric cytoplasmic enzyme essential in dividing cells that reduces ribonucleotides to deoxyribonucleotide precursors for DNA synthesis in S phase. It consists of two subunits, M1 Chain and M2 Chain. Complex allosteric
Staffan Eriksson, Britt-Marie Sjöberg
semanticscholar +3 more sources
TAS1553, a small molecule subunit interaction inhibitor of ribonucleotide reductase, exhibits antitumor activity by causing DNA replication stress [PDF]
Communications Biology, 2022 A small-molecule protein-protein interaction inhibitor of ribonucleotide reductase subunit, TAS1553, is shown to inhibit growth of both hematological and solid cancer xenograft tumors following oral administration in mice.
Hiroyuki Ueno +17 more
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The identification of viral ribonucleotide reductase encoded by ORF23 and ORF141 genes and effect on CyHV-2 replication [PDF]
Frontiers in Microbiology, 2023 IntroductionRibonucleotide reductase (RR) is essential for the replication of the double-stranded DNA virus CyHV-2 due to its ability to catalyze the conversion of ribonucleotides to deoxyribonucleotides, and is a potential target for the development of ...
Wenjie Cheng +24 more
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Ribonucleotide reductase subunit switching in hepatoblastoma drug response and relapse [PDF]
Communications Biology, 2023 In hepatoblastoma, the RRM2 subunit of ribonucleotide reductase is associated with disease progression, but in response to chemotherapy, subunit switching favours the less active RRM2B subunit which supports hepatoblastoma cell survival and relapse.
Anthony Brown +14 more
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Acetylation regulates ribonucleotide reductase activity and cancer cell growth
Nature Communications, 2019 Ribonucleotide reductase (RNR) catalyzes the de novo synthesis of deoxyribonucleoside diphosphates to provide dNTP precursors for DNA synthesis. Here the authors show that the availability of dNTPs, DNA replication, and cellular proliferation, are ...
Guo Chen +12 more
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Biomolecules, 2020 The main curative treatments for hepatocellular carcinoma (HCC) are surgical resection and liver transplantation, which only benefits 15% to 25% of patients. In addition, HCC is highly refractory and resistant to cytotoxic chemotherapy.
Pei-Ming Yang +2 more
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Haematologica, 2014 Myeloproliferative neoplasms are a varied group of disorders that can have prolonged chronic phases, but eventually accelerate and can transform into a secondary acute myeloid leukemia that is ultimately fatal.
Joshua F. Zeidner +11 more
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Characterization of a second class Ie ribonucleotide reductase [PDF]
Communications BiologyClass I ribonucleotide reductases (RNRs) convert ribonucleotides into deoxyribonucleotides under oxic conditions. The R2 subunit provides a radical required for catalysis conducted by the R1 subunit. In most R2s the radical is generated on a tyrosine via
Juliane John +6 more
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