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Inhibitors of the Cancer Target Ribonucleotide Reductase, Past and Present [PDF]

Biomolecules, 2022
Ribonucleotide reductase (RR) is an essential multi-subunit enzyme found in all living organisms; it catalyzes the rate-limiting step in dNTP synthesis, namely, the conversion of ribonucleoside diphosphates to deoxyribonucleoside diphosphates.
Sarah E. Huff, Jordan M. Winter, Chris G. Dealwis   +2 more
doaj   +3 more sources

Convergent allostery in ribonucleotide reductase [PDF]

Nature Communications, 2019
Ribonucleotide reductase (RNR) catalyzes the conversion of ribonucleotides to deoxyribonucleotides, which is an essential step in DNA synthesis. Here the authors use small-angle X-ray scattering, X-ray crystallography, and cryo-electron microscopy to ...
William C. Thomas, F. Phil Brooks, Audrey A. Burnim, John-Paul Bacik, JoAnne Stubbe, Jason T. Kaelber, James Z. Chen, Nozomi Ando   +7 more
doaj   +6 more sources

The identification of viral ribonucleotide reductase encoded by ORF23 and ORF141 genes and effect on CyHV-2 replication [PDF]

Frontiers in Microbiology, 2023
IntroductionRibonucleotide reductase (RR) is essential for the replication of the double-stranded DNA virus CyHV-2 due to its ability to catalyze the conversion of ribonucleotides to deoxyribonucleotides, and is a potential target for the development of ...
Wenjie Cheng, Wenjie Cheng, Wenjie Cheng, Qikang Chen, Qikang Chen, Qikang Chen, Yilin Ren, Yilin Ren, Yilin Ren, Ye Zhang, Ye Zhang, Ye Zhang, Ye Zhang, Liqun Lu, Liqun Lu, Liqun Lu, Liqun Lu, Lang Gui, Lang Gui, Lang Gui, Lang Gui, Dan Xu, Dan Xu, Dan Xu, Dan Xu   +24 more
doaj   +2 more sources

Ribonucleotide reductase subunit switching in hepatoblastoma drug response and relapse [PDF]

Communications Biology, 2023
In hepatoblastoma, the RRM2 subunit of ribonucleotide reductase is associated with disease progression, but in response to chemotherapy, subunit switching favours the less active RRM2B subunit which supports hepatoblastoma cell survival and relapse.
Anthony Brown, Qingfei Pan, Li Fan, Emilie Indersie, Cheng Tian, Nikolai Timchenko, Liyuan Li, Baranda S. Hansen, Haiyan Tan, Meifen Lu, Junmin Peng, Shondra M. Pruett-Miller, Jiyang Yu, Stefano Cairo, Liqin Zhu   +14 more
doaj   +2 more sources

Acetylation regulates ribonucleotide reductase activity and cancer cell growth

Nature Communications, 2019
Ribonucleotide reductase (RNR) catalyzes the de novo synthesis of deoxyribonucleoside diphosphates to provide dNTP precursors for DNA synthesis. Here the authors show that the availability of dNTPs, DNA replication, and cellular proliferation, are ...
Guo Chen, Yin Luo, Kurt Warncke, Youwei Sun, David S. Yu, Haian Fu, Madhusmita Behera, Suresh S. Ramalingam, Paul W. Doetsch, Duc M. Duong, Michael Lammers, Walter J. Curran, Xingming Deng   +12 more
doaj   +2 more sources

Sorafenib Inhibits Ribonucleotide Reductase Regulatory Subunit M2 (RRM2) in Hepatocellular Carcinoma Cells

Biomolecules, 2020
The main curative treatments for hepatocellular carcinoma (HCC) are surgical resection and liver transplantation, which only benefits 15% to 25% of patients. In addition, HCC is highly refractory and resistant to cytotoxic chemotherapy.
Pei-Ming Yang, Li-Shan Lin, Tsang-Pai Liu   +2 more
doaj   +2 more sources

Characterization of a second class Ie ribonucleotide reductase [PDF]

Communications Biology
Class I ribonucleotide reductases (RNRs) convert ribonucleotides into deoxyribonucleotides under oxic conditions. The R2 subunit provides a radical required for catalysis conducted by the R1 subunit. In most R2s the radical is generated on a tyrosine via
Juliane John, Daniel Lundin, Rui M. Branca, Rohit Kumar, Vivek Srinivas, Hugo Lebrette, Martin Högbom   +6 more
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A phase II trial of sequential ribonucleotide reductase inhibition in aggressive myeloproliferative neoplasms

Haematologica, 2014
Myeloproliferative neoplasms are a varied group of disorders that can have prolonged chronic phases, but eventually accelerate and can transform into a secondary acute myeloid leukemia that is ultimately fatal.
Joshua F. Zeidner, Judith E. Karp, Amanda L. Blackford, B. Douglas Smith, Ivana Gojo, Steven D. Gore, Mark J. Levis, Hetty E. Carraway, Jacqueline M. Greer, S. Percy Ivy, Keith W. Pratz, Michael A. McDevitt   +11 more
doaj   +2 more sources

Hydroxyurea-Mediated Cytotoxicity Without Inhibition of Ribonucleotide Reductase

Cell Reports, 2016
In many organisms, hydroxyurea (HU) inhibits class I ribonucleotide reductase, leading to lowered cellular pools of deoxyribonucleoside triphosphates. The reduced levels for DNA precursors is believed to cause replication fork stalling. Upon treatment of
Li Phing Liew, Zun Yi Lim, Matan Cohen, Ziqing Kong, Lisette Marjavaara, Andrei Chabes, Stephen D. Bell   +6 more
doaj   +2 more sources

Aerobic Vitamin B12 Biosynthesis Is Essential for Pseudomonas aeruginosa Class II Ribonucleotide Reductase Activity During Planktonic and Biofilm Growth

Frontiers in Microbiology, 2018
Pseudomonas aeruginosa is a major pathogenic bacterium in chronic infections and is a model organism for studying biofilms. P. aeruginosa is considered an aerobic bacterium, but in the presence of nitrate, it also grows in anaerobic conditions.
Anna Crespo, Núria Blanco-Cabra, Eduard Torrents   +2 more
doaj   +2 more sources