Results 91 to 100 of about 209,934 (286)

RRM2B: An oxygen-requiring protein with a role in hypoxia

Molecular & Cellular Oncology, 2017
How tumor cells adapt and survive under hypoxia significantly impacts patient prognosis. We recently demonstrated that the oxygen-requiring ribonucleotide reductase (RNR) enzyme, which provides cells with deoxyribonucleotides, responds to limited oxygen ...
Iosifina P. Foskolou, Ester M. Hammond
doaj   +1 more source

Acute kidney injury and iron metabolism: A narrative review focusing on pathophysiology and therapy

Smart Molecules, EarlyView.
Schematic illustration of acute kidney injury and iron metabolism (By Figdraw). Image for iron metabolism, including uptake, storage, utilization, export: Reproduced with permission. Abstract Acute kidney injury (AKI) represents a substantial challenge to public health and is characterized by elevated occurrence and fatality rates.
Xinyu Tan, Man Li, Jing Chen, Gang Liu, Zhixiang Lu   +4 more
wiley   +1 more source

Diversity in Overall Activity Regulation of Ribonucleotide Reductase*

Journal of Biological Chemistry, 2015
Background: Ribonucleotide reductase (RNR) makes DNA building blocks. Results: Binding of three dATP molecules to the Pseudomonas aeruginosa class I RNR α subunit inactivates the enzyme by inducing an inert α4 complex.
V. Jonna, Mikael Crona, R. Rofougaran, D. Lundin, S. Johansson, K. Brännström, B. Sjöberg, A. Hofer   +7 more
semanticscholar   +1 more source

Senescence Cell Induction Methods Display Diverse Metabolic Reprogramming and Reveal an Underpinning Serine/Taurine Reductive Metabolic Phenotype

Aging Cell, EarlyView.
This study reveals that in vitro senescence induction methods significantly influence intracellular biomolecular profiles, showing both shared and unique metabolic responses. A novel bioanalytical pipeline was developed to explore these subphenotypes, highlighting the importance of targeting metabolic redox circuits and serine/taurine pathways for ...
Domenica Berardi, Gillian Farrell, Abdullah AlSultan, Ashley McCulloch, Nicole M. Hall, Rui Pedro Pereira Sousa, Melanie Jimenez, Colin Selman, Ilaria Bellantuono, Caroline H. Johnson, Zahra Rattray, Nicholas J. W. Rattray   +11 more
wiley   +1 more source

Cofactor Selectivity in Methylmalonyl Coenzyme A Mutase, a Model Cobamide-Dependent Enzyme. [PDF]

, 2019
Cobamides, a uniquely diverse family of enzyme cofactors related to vitamin B12, are produced exclusively by bacteria and archaea but used in all domains of life.
Mok, Kenny, Park, Jong, Quanstrom, Kathryn, Sokolovskaya, Olga, Taga, Michi, Tran, Jennifer   +5 more
core   +1 more source

An HWE‐Family Histidine Kinase Modulates Brucella Cell Envelope Properties and Host Innate Immune Response

Molecular Microbiology, EarlyView.
The HWE‐family histidine kinase PhyK regulates the cell envelope structure of the intracellular pathogen Brucella ovis and affects how the host immune system responds to this bacterium. Deletion of phyK alters bacterial survival in the face of detergent stress and reduces immune activation in infected macrophages.
Xingru Chen, Emily Perez, Eleanor C. Scheeres, Rosemary Northcote, Aretha Fiebig, Andrew J. Olive, Sean Crosson   +6 more
wiley   +1 more source

A Simple and Sensitive Ribonucleotide Reductase Assay

Journal of Biomedical Science, 1998
Ribonucleotide reductase (RR) is a key regulatory enzyme in the DNA synthesis pathway and is the target of the cancer chemotherapeutic agent hydroxyurea. The study of RR is significantly hindered by the tedious and labor-intensive nature of enzymatic assay.
C. Patrick Reynolds, Tomas Frgala, Bingsen Zhou, Yun Yen, Ambrose Jong, Kefei Yu   +5 more
openaire   +3 more sources

Entwicklung und Validierung eines Bioassays zum Nachweis induzierter Genaktivität für den Einsatz auf der Internationalen Raumstation [PDF]

, 2007
Neben der fehlenden Schwerkraft stellt die Strahlenbelastung des Astronauten einen limitierenden Faktor für den Langzeitaufenthalt des Menschen im Weltraum dar.
Arenz, Andrea
core  

Cell-cycle-dependent transcriptional and translational DNA-damage response of 2 ribonucleotide reductase genes in S. cerevisiae [PDF]

, 2012
The ribonucleotide reductase (RNR) enzyme catalyzes an essential step in the production of deoxyribonucleotide triphosphates (dNTPs) in cells. Bulk biochemical measurements in synchronized Saccharomyces cerevisiae cells suggest that RNR mRNA production ...
Altschuler SJ, An X, Bregman A, Cai L, Cerqueira NM, Cerqueira NM, Chabes A, Chabes A, Chabes A, Domkin V, Elledge SJ, Hoeijmakers JH, Jordheim LP, Lee YD, Nick McElhinny SA, Perlstein DL, Raj A, Raj A, Sabouri N, Tan RZ, Tomar RS, Trcek T, Yao R, Youk H, Zenklusen D, Zhao X, Zhao X, Zhao X   +27 more
core   +1 more source

Characterization of novel beta-galactosidase activity that contributes to glycoprotein degradation and virulence in Streptococcus pneumoniae.

, 2009
The pneumococcus obtains its energy from the metabolism of host glycosides. Therefore, efficient degradation of host glycoproteins is integral to pneumococcal virulence.
Andrew, Peter W, Homer, Karen A, Rao, Susmitha G, Terra, Vanessa S, Yesilkaya, Hasan   +4 more
core   +2 more sources